D-I-TASSER P04198-D1

D-I-TASSER results for P04198-D1

[Click result.zip to download all results on this page]

Input Sequence in FASTA format

>P04198 (464 residues)
MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPP
LSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGF
SAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELA
HPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPG
GRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTIT
VRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLK
SVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKV
VILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
Confidence	99877666877666787777777877677897554467789999742211001368999999988888888887554444568832257876566766788876667876666776777776445677767443567788666777889888888877677777888888788888888887645678766678888778888887766777878876667777777766776678898888888777777777888887766656676666666677533167778877887777777777888888988778886555678876555666788999888888865566666798877777888778888876555532355677888999999999999999997656778886579999999999999999999999999999999999999999998719
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC
Prediction	64414242012123632311122131000444422134346145254301220102011221252434444443241145122344213423344210223244331424234511132223364255433541443543444434434343434333434342344344333322242433444214334122133434444332443444444444434434433333344432244424343444344444444533453544554444644413223145433344443344343434354354544444445443554444444444445324444553444543555445443544344645344444432454532331242255105502510430261024047362211030042005004402631541454354045435404520561478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

Contact Map

Distance Map

Hydrogen bond networks

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank

PDB
hit

ID1

ID2

Cov

Norm.
Zscore

Download
alignment

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

SS
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MPSCSTSTMPGMICKNPDLEFDSLQPCFYPDEDDFYFGGPDSTPPGEDIWKKFELLPTPPLSPSRGFAEHSSEPPSWVTEMLLENELWGSPAEEDAFGLGGLGGLTPNPVILQDCMWSGFSAREKLERAVSEKLQHGRGPPTAGSTAQSPGAGAASPAGRGHGGAAGAGRAGAALPAELAHPAAECVDPAVVFPFPVNKREPAPVPAAPASAPAAGPAVASGAGIAAPAGAPGVAPPRPGGRQTSGGDHKALSTSGEDTLSDSDDEDDEEEDEEEEIDVVTVEKRRSSSNTKAVTTFTITVRPKNAALGPGRAQSSELILKRCLPIHQQHNYAAPSPYVESEDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILERQRRNDLRSSFLTLRDHVPELVKNEKAAKVVILKKATEYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC

4btgA

0.12

0.11

3.82

1.46

SPARKS-K

NRAIKADAVGKVPPTASEHELFHHITTDFPDAAYVYRVGRTATYPNSDLRRMLTALSSGALAPATAFSRGNFDANAVVSSVLTIGRLWSPSTPKELDPSARLRNTGIDQLRSNLAL---FIA---YQDMVKQR-GRAEVIFSDEELSSTIIPWFIEAMSEVSPFKLRPINETTSYIGQTSAIMGQPSHVVVYEDWQFAKETPVKLANNSNQRFLDVEPGISDRMSATLAPIGNTFAVSAYEAVSQRGTVNSNGAEALDRDGIVDESLEARHNPEVVVSEH-------QGVAAEQGSLYLVWNVRT---------ELRIPVGYNAIEGGSIRTPEPPIQPSEVLQAKVLDLANHEASTEFASVTIRNKRYTAEVKEF----------ELLGGQRRE-------RVRILKPTVA---HAIIQMWYSWFVEDDRTLAAARRTKLAIDGRRMQNAVTLLRKIEMIGTT

2pffB

0.09

3.32

1.87

MapAlign

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGKAAQDVWNRADNHFKDTYGFSILDIVINNPFTQPALTLMEKAAFEDLKESLVEVVFYRGMTMYVAAGDLRALDTV--

1nkpA

0.55

0.10

2.98

2.41

HHsearch

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHMNVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLGGC

1vt4I3

0.08

3.03

0.87

CEthreader

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----------------------------

7kogB

0.08

3.07

0.80

EigenThreader

LADEEARERATLLGKFRNLEHDLDNIREQLEEEAEGKADIQRQLSKANAEAQLWRTKYESEGVARAEELEEAKRKLQARLAEAQLEVDRATAIANAAEKKAKAIDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEAQEQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKQKKRLEVEKDELQAALEEAEAALEQEENKVLRSQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADIN------ELEIALDHANK-------ANSEAQKTIKKYQQQLKDVQTALEEEQRARDDAREQLGISERRANALQNELEESRTLLEQADRGRRQAEQELGDAHEQINELAAQATSASAAKRKLEGELQTLHADLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEKLRKALETQIKELQIR

1nkpA

0.55

0.10

2.98

0.93

FFAS-3D

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHMNVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLGGC

7jtkA

0.14

0.12

3.98

1.38

SPARKS-K

LSCVAFDVKGQLHDTLHARKPTALDGALVKGFEKQALPEETVQVEGDDFPKKFEFVASAPSIPGKKHDLDSSSKLE--FAVSYSDVGGQAFQSFDLKPLAAQGG--VSSIIVAVMYWPGLIV-PELKQTILNLRDHHGVQLDA-----ADAIQAIDPAERVPVTRQFQDQSLDEASAGRAAEPAPVKKLRIDLSWTFWPPPPP------------------------EEPPEEPALEYNLVMYNKDGEEVQSISTGNREATRAGRPEKVDPYEFKERDVIYLDVPDLPA---EVRSMVLLVTNYDEENG----------FTRVR--TVRCRLVDVSNGEAPLPGSKAAVAAAAAAAEQGLAAPPNPERVLSKYEDDKEYAD-----------------SAFNVFRGAVAAFIGQEP-------DTIINQLKAYLEATKKQKAAEAAAAAAAEESGEEITADPKP

1by1A

0.11

0.02

0.78

0.33

CNFpred

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKGFDTTAINKSYYNVVLQLETENEYSKELQTVLSTYLRPLQTSISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTL

6yvuB

0.05

0.02

1.03

0.50

DEthreader

--------------------KSKVLTALSRLQ-K-------SGRI----N-----GFHGRLGDLGV------IDDSFDVAISTA----------------------CPRLDDVVARFILRLRQFAFYSVLRDTLVAQ-N----------L-----KQA---------N-NVAYGKRIDISGTSG-H----------------------------------------------------------------------------ENDNMETNLELQSLKMEDENEKSIENEK---YSSELRELDVELIESKINELSY-----------------------------D--------------RK-LNVQRDVKELGILKKKRFDEFMAGFNIISMTLKEMYQMITM--------DFRNVSIVANYIKERTKN-----------------------------------

1vt4I3

0.08

3.02

1.79

MapAlign

--------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----

(a)	ID1 is the number of template residues identical to query divided by number of aligned residues.
(b)	ID2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e)	Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f)	Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Click to view	Rank^a	Download	Estimated TM-score^b
	1	model1.pdb.gz	0.4314

(a)

D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.

(b)

The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	Download Alignment
1	3zyvA	0.40	7.05	0.048	0.644	model1_3zyvA.pdb.gz
2	2d33A	0.39	6.49	0.080	0.591	model1_2d33A.pdb.gz
3	3ig5A	0.39	7.06	0.055	0.629	model1_3ig5A.pdb.gz
4	3nztA	0.38	6.50	0.052	0.578	model1_3nztA.pdb.gz
5	3ln7A	0.36	6.74	0.055	0.573	model1_3ln7A.pdb.gz
6	4jzaA	0.32	7.60	0.035	0.554	model1_4jzaA.pdb.gz
7	1dgjA2	0.31	7.52	0.043	0.528	model1_1dgjA2.pdb.gz
8	1ffvB3	0.27	6.42	0.014	0.401	model1_1ffvB3.pdb.gz
9	3lmmD	0.23	7.66	0.028	0.394	model1_3lmmD.pdb.gz
10	1xfiA	0.23	6.61	0.050	0.353	model1_1xfiA.pdb.gz

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)

GO term	Cscore^GO	Name
GO:1901363	0.86	heterocyclic compound binding
GO:0097159	0.86	organic cyclic compound binding
GO:0003700	0.85	transcription factor activity, sequence-specific DNA binding
GO:0003676	0.84	nucleic acid binding
GO:0003677	0.83	DNA binding
GO:0000975	0.68	regulatory region DNA binding
GO:0044212	0.67	transcription regulatory region DNA binding
GO:0044877	0.61	macromolecular complex binding
GO:0070888	0.58	E-box binding
GO:0032403	0.57	protein complex binding

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Biological Process (BP)

GO term	Cscore^GO	Name
GO:0065007	0.95	biological regulation
GO:0050789	0.95	regulation of biological process
GO:0050794	0.94	regulation of cellular process
GO:0080090	0.91	regulation of primary metabolic process
GO:0060255	0.91	regulation of macromolecule metabolic process
GO:0031323	0.91	regulation of cellular metabolic process
GO:0006355	0.90	regulation of transcription, DNA-templated
GO:0006357	0.86	regulation of transcription from RNA polymerase II promoter
GO:0048522	0.82	positive regulation of cellular process
GO:0044699	0.82	single-organism process
GO:0009987	0.82	cellular process
GO:0009893	0.81	positive regulation of metabolic process
GO:0031325	0.80	positive regulation of cellular metabolic process
GO:0010604	0.80	positive regulation of macromolecule metabolic process
GO:0045893	0.79	positive regulation of transcription, DNA-templated
GO:0048519	0.70	negative regulation of biological process
GO:0045944	0.70	positive regulation of transcription from RNA polymerase II promoter
GO:2000026	0.69	regulation of multicellular organismal development
GO:0048523	0.69	negative regulation of cellular process
GO:0044763	0.69	single-organism cellular process
GO:0008152	0.69	metabolic process
GO:0071704	0.68	organic substance metabolic process
GO:0050896	0.68	response to stimulus
GO:0045595	0.68	regulation of cell differentiation
GO:0044238	0.67	primary metabolic process
GO:0044237	0.66	cellular metabolic process
GO:0043170	0.66	macromolecule metabolic process
GO:0044260	0.65	cellular macromolecule metabolic process
GO:0051241	0.64	negative regulation of multicellular organismal process
GO:0010941	0.64	regulation of cell death
GO:0051716	0.63	cellular response to stimulus
GO:0051093	0.63	negative regulation of developmental process
GO:0045596	0.63	negative regulation of cell differentiation
GO:0042127	0.63	regulation of cell proliferation
GO:0048583	0.62	regulation of response to stimulus
GO:0010942	0.62	positive regulation of cell death
GO:0008284	0.62	positive regulation of cell proliferation
GO:0006950	0.62	response to stress
GO:0065008	0.61	regulation of biological quality
GO:0051246	0.60	regulation of protein metabolic process
GO:0033554	0.60	cellular response to stress
GO:0007165	0.60	signal transduction
GO:0048584	0.59	positive regulation of response to stimulus
GO:0032268	0.59	regulation of cellular protein metabolic process
GO:0016043	0.59	cellular component organization
GO:0009628	0.59	response to abiotic stimulus
GO:0065009	0.58	regulation of molecular function
GO:0051128	0.58	regulation of cellular component organization
GO:0048878	0.58	chemical homeostasis
GO:0044710	0.58	single-organism metabolic process
GO:0043933	0.58	macromolecular complex subunit organization
GO:0042981	0.58	regulation of apoptotic process
GO:0032270	0.58	positive regulation of cellular protein metabolic process
GO:0007166	0.58	cell surface receptor signaling pathway
GO:0080134	0.57	regulation of response to stress
GO:0055072	0.57	iron ion homeostasis
GO:0050790	0.57	regulation of catalytic activity
GO:0033043	0.57	regulation of organelle organization
GO:0030162	0.57	regulation of proteolysis
GO:0009314	0.57	response to radiation
GO:0006996	0.57	organelle organization
GO:0006875	0.57	cellular metal ion homeostasis
GO:0002682	0.57	regulation of immune system process
GO:2001022	0.56	positive regulation of response to DNA damage stimulus
GO:2000573	0.56	positive regulation of DNA biosynthetic process
GO:0060070	0.56	canonical Wnt signaling pathway
GO:0051782	0.56	negative regulation of cell division
GO:0051276	0.56	chromosome organization
GO:0050679	0.56	positive regulation of epithelial cell proliferation
GO:0048146	0.56	positive regulation of fibroblast proliferation
GO:0045656	0.56	negative regulation of monocyte differentiation
GO:0043280	0.56	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0032204	0.56	regulation of telomere maintenance
GO:0010332	0.56	response to gamma radiation
GO:0006974	0.56	cellular response to DNA damage stimulus
GO:0006879	0.56	cellular iron ion homeostasis
GO:0006464	0.56	cellular protein modification process
GO:0006338	0.56	chromatin remodeling
GO:0000165	0.55	MAPK cascade
GO:0009892	0.50	negative regulation of metabolic process

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Cellular Component (CC)

GO term	Cscore^GO	Name
GO:0044424	1.00	intracellular part
GO:0043229	0.82	intracellular organelle
GO:0043231	0.75	intracellular membrane-bounded organelle
GO:0044422	0.74	organelle part
GO:0044446	0.73	intracellular organelle part
GO:0005634	0.73	nucleus
GO:0044428	0.64	nuclear part
GO:0005654	0.54	nucleoplasm

Download full result of the above consensus prediction.

Click the graph to show a high resolution version.

(a)

Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.

(b)

The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	3ig5A	0.389	7.06	0.055	0.629	6.3.2.2	NA
2	0.060	2ipyA	0.290	7.36	0.023	0.474	4.2.1.3	NA
3	0.060	2fxhA	0.336	7.30	0.066	0.556	1.11.1.7 1.11.1.6	NA
4	0.060	1cjyA	0.333	7.46	0.041	0.567	3.1.1.4 3.1.1.5	NA
5	0.060	1ea0A	0.302	7.37	0.040	0.504	1.4.1.13	NA

	Click on the radio buttons to visualize predicted active site residues.
(a)	Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:

Click to view	Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Download Complex	Predicted binding site residues
	1	0.01	1fiqA	0.145	4.88	0.038	0.190	0.58	FES	complex1.pdb.gz	89,90,91,93,98

	Click on the radio buttons to visualize predicted binding site and residues.
(a)	Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b)	BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c)	TM-score is a measure of global structural similarity between query and template protein.
(d)	RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(f)	Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

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References:
1.	Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.