D-I-TASSER results for O15040-D1

Input Sequence in FASTA format

>O15040 (1411 residues)
MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLY
CRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRF
DVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDY
SQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGL
RLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGW
VLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTS
TVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGS
GLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTC
HSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQE
NTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDE
PCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSA
EQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGS
VGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQ
QDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGA
GLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALS
DDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYRE
GVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDD
DHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSL
LGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLW
LCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCP
TGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEP
PVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALS
TRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRL
TKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI

Predicted Secondary Structure

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
Sequence
MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALSTRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRLTKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI
Prediction
CCCCCCCSSSCCCCCHHHHHHHHCHHHHHCCCCCCSSSSSSSCCCCSSSSSCCCCSSSSSSCCCCCSSSSSCCCCCCCSSSSSSSCCCCCSSSSSSCCCSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCSSSSSSCCCCCSSSSSCCCCSSSSSSSSCCCCCCCCSSSSSCCCCSSSSSCCCCSSSSSSCCSSSSSSCCCCSSSSSCCCCCCCCCCCSSSSCCCCCCCCCCSSSSSCCCCSSSSSCCCCSSSSSSSCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCSSSSSCCCSSSSSSCCCCSSSSSSCCCCCSSSSSSSCCSSSSSCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCSSSSCCCCCSCCCCCCCCCCCCSSCCCCCCSSSSCCCCCSSSSSSCCCCSSSSSCCSCCCCCCCSSSCCCCCSSSSCCCCCSSSSSCCCCSSSSSCCCCCCCCCCCCSSSCCCCSSSSSSCCCSSSSSSCCCCSSSSCCCCCCCCCCCCCSSCCCCCCCCCSSSSSSSCCCCSSSSSCCCCCSSSSCCCCCCCCCCCCCCSSSSCCCCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCSSSSCCCCSSSSSCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCSSSSSSCCCCSSSSCCCCCCCCCCCSSCCCCCCSSSSSCCCCSSSSSCCCCCSSSSSCCCCCCCCCCCSSCCCCCCCCCSSSSSSCCCCSSSSSSCCCCSSSSSCCCCCCCCCCCCCCSSCCCCCCCCCCSSSSSSSCCCCCSSSSSCCCCCSSSSCCCCCCCCCCCCCSSCCCCCSSSSSSCCCSSSSSCCCCCSSSSSCCCCCCCCCCCCSSCCCSSSSSSSCCCCSSSSSCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Confidence
9987786221035626999987114554233446457999975898599971898499997677711124327888866899985689977999938978999984688898864048886156777756899977999889995499779999971554313424899549835886526991898616438999827761886236667788863267446777888737999668872677337856987431111102688740036777787777767764411134325788669996398489996578616776416776479998377367633787511221245665555556555665555555555567777776655677766666567787776666777787766678877666676777888766666677777776544566776666666777778888887777778777778899877788767778777776667777889765677877667888888887776767788888987777888888788778888878888877778888887778888888888878889987788887778877778888888888888888888898888898777678888778888888888888777888998888887888777778888888877778877777788887777888887789987777887767776667899888777655678766666543456666544344566676655577754321002578742675179972445688778873114787427873699977988836985899722214788875277278726984389828999079949997056778876765125468756999964885998946984898446665887889855811687777327999977997199991798579863776678888998526622553112467515664210342212333455443223356664230367875268545883899955975999647755653345577776467872676245433688844999946983999678888778864112678644788506981899938995999714678889998756467667762268982269849999089968997257788888888873571688766653057999847997799993899499973687789898874683787427999649879999389959997257789989986245176279999858992999868995898446567788998766456688998745476509

H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400
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Sequence
MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALSTRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRLTKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI
Prediction
6343444000210220240044014414430434301000000133000000210000000132341232315445310000000034320000013300000010245444444413413244314210000000440220000134000000113344421403200426220000111442000001000000204444133124342545030000002323454301000012311003043613033124245215442430404342444654444444331110211043200000132000001122121012234334013000243200012344212222222342443444444244444434444424244444444444544444645454545555455565655444465644454565554445435436555454544454564556665555564665554454565545546665565464644545554454444645554465555465646444645564544544636554465455665655644556556555456446554666645646555445655555654455566655655656556456465444654556556445645444645644454545645555446555456646465546554654446565665544456554655445444464445656555456556555454645554445523445554444444432444424434444444244443444234141122213323144400000135430120211222131230434123001024110000012411000000204144443124134411100132200000023000000000034413343432404130100000100000003412000234044431424303304335443121010103441000000141100102314443132443211101111111122100001113022111212323122012303112121213242010012220000003410001031310232134114442343430221113224144310000012310000000233433121121115241110000210000001310000000134114334044033443342311000113100000023000000000224214233331230434242331301100000320000000241000002103442141430441433311000103300000033010000000034302042033011100100002510000003422001011312341424415342324464435541324

Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact, Hydrogen and Distance Map Used in D-I-TASSER simulation

D-I-TASSER simulation is guided by the consensus contact map (left figure), distance map (middle figure) and Hydrogen bond network (right figure) derived based on confidence scores of AttentionPotential. In the contact, distance map and hydrogen bond networks, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map and hydrogen bond network, a color scale represents a distance of 1-20+ angstroms or a angle of 0-180 degree.

Top 10 threading templates used by D-I-TASSER

Rank	PDB hit	ID1	ID2	Cov	Norm. Zscore	Download alignment		20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140                1160                1180                1200                1220                1240                1260                1280                1300                1320                1340                1360                1380                1400                    |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
							SS	CCCCCCCSSSCCCCCHHHHHHHHCHHHHHCCCCCCSSSSSSSCCCCSSSSSCCCCSSSSSSCCCCCSSSSSCCCCCCCSSSSSSSCCCCCSSSSSSCCCSSSSSSCCCCCCCCCCSSSSSSCCCCCCCCSSSSSSCCCCCSSSSSCCCCSSSSSSSSCCCCCCCCSSSSSCCCCSSSSSCCCCSSSSSSCCSSSSSSCCCCSSSSSCCCCCCCCCCCSSSSCCCCCCCCCCSSSSSCCCCSSSSSCCCCSSSSSSSCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCSSSSSCCCSSSSSSCCCCSSSSSSCCCCCSSSSSSSCCSSSSSCCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSCCCCCCSSSSCCCCCSCCCCCCCCCCCCSSCCCCCCSSSSCCCCCSSSSSSCCCCSSSSSCCSCCCCCCCSSSCCCCCSSSSCCCCCSSSSSCCCCSSSSSCCCCCCCCCCCCSSSCCCCSSSSSSCCCSSSSSSCCCCSSSSCCCCCCCCCCCCCSSCCCCCCCCCSSSSSSSCCCCSSSSSCCCCCSSSSCCCCCCCCCCCCCCSSSSCCCCCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCCCSSSSCCCCSSSSSCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCSSSSSSCCCCSSSSCCCCCCCCCCCSSCCCCCCSSSSSCCCCSSSSSCCCCCSSSSSCCCCCCCCCCCSSCCCCCCCCCSSSSSSCCCCSSSSSSCCCCSSSSSCCCCCCCCCCCCCCSSCCCCCCCCCCSSSSSSSCCCCCSSSSSCCCCCSSSSCCCCCCCCCCCCCSSCCCCCSSSSSSCCCSSSSSCCCCCSSSSSCCCCCCCCCCCCSSCCCSSSSSSSCCCCSSSSSCCCCCSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
							Seq	MASISEPVTFREFCPLYYLLNAIPTKIQKGFRSIVVYLTALDTNGDYIAVGSSIGMLYLYCRHLNQMRKYNFEGKTESITVVKLLSCFDDLVAAGTASGRVAVFQLVSSLPGRNKQLRRFDVTGIHKNSITALAWSPNGMKLFSGDDKGKIVYSSLDLDQGLCNSQLVLEEPSSIVQLDYSQKVLLVSTLQRSLLFYTEEKSVRQIGTQPRKSTGKFGACFIPGLCKQSDLTLYASRPGLRLWKADVHGTVQATFILKDAFAGGVKPFELHPRLESPNSGSCSLPERHLGLVSCFFQEGWVLSWNEYSIYLLDTVNQATVAGLEGSGDIVSVSCTENEIFFLKGDRNIIRISSRPEGLTSTVRDGLEMSGCSERVHVQQAEKLPGATVSETRLRGSSMASSVASEPRSRSSSLNSTDSGSGLLPPGLQATPELGKGSQPLSQRFNAISSEDFDQELVVKPIKVKRKKKKKKTEGGSRSTCHSSLESTPCSEFPGDSPQSLNTDLLSMTSSVLGSSVDQLSAESPDQESSFNGEVNGVPQENTDPETFNVLEVSGSMPDSLAEEDDIRTEMPHCHHAHGRELLNGAREDVGGSDVTGLGDEPCPADDGPNSTQLPFQEQDSSPGAHDGEDIQPIGPQSTFCEVPLLNSLTVPSSLSWAPSAEQWLPGTRADEGSPVEPSQEQDILTSMEASGHLSTNLWHAVTDDDTGQKEIPISERVLGSVGGQLTPVSALAASTHKPWLEQPPRDQTLTSSDEEDIYAHGLPSSSSETSVTELGPSCSQQDLSRLGAEDAGLLKPDQFAESWMGYSGPGYGILSLVVSEKYIWCLDYKGGLFCSALPGAGLRWQKFEDAVQQVAVSPSGALLWKIEQKSNRAFACGKVTIKGKRHWYEALPQAVFVALSDDTAWIIRTSGDLYLQTGLSVDRPCARAVKVDCPYPLSQITARNNVVWALTEQRALLYREGVSSFCPEGEQWKCDIVSERQALEPVCITLGDQQTLWALDIHGNLWFRTGIISKKPQGDDDHWWQVSITDYVVFDQCSLFQTIIHATHSVATAAQAPVEKVADKLRMAFWSQQLQCQPSLLGVNNSGVWISSGKNEFHVAKGSLIGTYWNHVVPRGTASATKWAFVLASAAPTKEGSFLWLCQSSKDLCSVSAQSAQSRPSTVQLPPEAEMRAYAACQDALWALDSLGQVFIRTLSKSCPTGMHWTRLDLSQLGAVKLTSLACGNQHIWACDSRGGVYFRVGTQPLNPSLMLPAWIMIEPPVQPAGVSLVSVHSSPNDQMLWVLDSRWNVHVRTGITEEMPVGTAWEHVPGLQACQLALSTRTVWARCPNGDLARRYGVTDKNPAGDYWKKIPGSVSCFTVTASDELWAVGPPGYLLQRLTKTFSHSHGTQKSSQAAMPHPEDLEDEWEVI
1	6jp6A	0.09	0.06	2.18	1.58	SPARKS-K		------------------------------MKDLSHYALCVKFYNDYVLAGYG-PFIHVYDYHSATLINKCRLFHYNKVHGLSLSS-EGKILAYGAR--SVTIVEL-EDVLKKESLVDFER---INSDWITGATFSFDNLQIYLLTCYNKVLICDL-------NCEVLFRKRSILGIIKVFGVYVNAGTVGGVIIWDLFSETKIHNLL---GHEGSFYVNLSNN----GRYVASCSDDRIRLWDL-----------------ETGKQLSVGWSHTAR------------IWNLMFFDNDKLISVSECTCRVWNIIESNVYEVHLIKS-IWGVDVKDEMIAVTSGNDGRLKLIDL----LQLKRHGDEETSFSLDDIAKQCGD-----IFEKNESIKGFQWFSFGVIAITSLGKILKYSD-----------------VTKQWKLLLTNEKFNSYPITNGIQ----------------------------------------------------------------TQNIAVFSNNKSD--------------------------------ILLIKFSKD-------------------------------------------------------------------------------------------------SADIIETEEFHLDELSKTNNCLVTEYDD-------DSFLLTLQSPNPREK-------------------------------FVCLEISLQNLKIKSKHCFNKPEN------------------------------FSSSCLTSFRNHILVGSRFSTLVIYNLLDESEEPFIIDNSAVFSVTNRDGYVFIELTKNRLSYKVLHSNKMMKGF--------LEGAFFNGEYITYGFKSSLFYLYNETN--CYELASEVCGGSHRLWNLAKITDGHVLMYIKAHLRKIYN--------SIVPETLENGVHGREIRDISICPVSIFCTASEDTTIKLGYFNNR---TGKVQNFWTQR--------------------------------------------KHVSGLQRCQFINHKLMISSSAREELFLWELNDKYNKRPYMTIRQALPVLRIMDFDVKFISQSGDFLLVTVYSDSKIWHYRENQNKFDLIMQGRYKTCCLFNVVFIKEELLVVITDGHLVVYNITEYVPFSVDPISGDPAPVAQLPVKSLDYSATILTGGDDNGLGLSNLKLD----DSNKVTLKTSDFIAAAASSTITSGMLINGGKEVITTSVDQVIRAWEITT-----------VADTGSLEIISNSEKTLLIGGVGSIWKK---------------------------------------------------------------------------
2	6jplA	0.10	0.06	2.14	4.13	CNFpred		------------------------------DLSHYGPALCVKFYNDYVLAGYG-PFIHVYDYHATLINKCRLFH-YNKVHGLSLSS-EGKILAYGA--RSVTIVELEDVLK--ESLVDFER---INSDWITGATFSFDNLQIYLLTCYNKVLICDLNC---EVLFRKSLG-ILYSGIIKVFKVYVNAGTVMGGVIIWDLETKIHNLLGHE----SIFYVNLSNN-----GRYVASCSRSIRLWDLE-TGKQLSVGWSHT---------------------------ARIWNLMFFDNDSKLISVSECTCRVWNIINVAELSISN-IKSIWGVDVKDEMIAVTSGNDGRLKLIDLL----------------QLKRHGDE-------------------------------------------------------------------------ETSFSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDIAKQCGDIFEKN------------------------------------------ESIKGFQWFSFGVIAITSLGKILKYSDV--TKQWKLLLT-YPITNGIQTQNIAVFSNNSDILLIKFSKDADIIETEEFHLDSKTNNCLVTESFLLTLQSPEKFVCLEISLQNLKIKSKHCFNKPFSSSCLTSFRNHILVGSRFSTLVIYNL-EPFII-GDTTTSIEFVEDKDNSAVFSVTNRDGYYVFIELTYKVLHSNKMM-------KGFLEGAFFNEYITYGFKS-SLFYLYNETNCYELASEVCG-------HRLWNLAKIDGHVLMYIKRFHLRKIYNSETLENGVHEIRDISICPVSNTNTN-FKDGHIFCTASE--DTTIKLGYFNN-QNFWTQRKH--VSGLQRCQFINHKLMISSSARELFLWELND-RPYMTIRQAL-----LRIMDFDVKFIGDFLLVTVYSSTIKIWHYREQNKFDLIMQGRYKTCCLFNVVFIALK-----EELLVVISPTD-GHLVVYNITEYVPFSVDP-GDLVDHK-TISNLPA-SGVKSLDYVASATILTGGDDNGLGLSNLKLNKVTLKTSDFI-STITSGMLINGKEVITTSVDQVIRAWE-------------------------------
3	6jp6A	0.08	0.05	1.93	1.16	MapAlign		---------------------------------HYGPALCVKFYNDYVLAGYG-PFIHVYDYHSATLINKCRLFHYNKVHGLSLS--SEGKILAYGA-RSVTIVELE--DVLKKESLVDFER--INSDWITGATFSFDNLQIYLLT--CYNKVLICDLNCEVLFRKSLGRSILYSGIIKVKVYVNAGTVMGGVIIWDLFSETKIHNLLG------HEGSIFYVNLSNNGRYVASCSD-DRSIRLWDLEGKQLSVGWSHTAR---------------------------IWNLMFFDNDSKLISVSEDCCRVWNILSISNVYEVHLIKSIWGVDVKEMIAVTSGNDGRLKLIDLL-------------------------------------------------------------------------------QLKRHGDEETSFSL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDIAKQCGDIFEKNESIKGFQWFSFGVIAITSLGKILKYSDVTKQWKLLLTNEKFPITNGIQTQNIAVFS-NNKSDILLIKFSKDSADIIETEELSKTNNCLVDSFLLTLQSPREKFVCLEISLQNLKIKSKHCFNKNFSSSCLTSFRNHILVGSRFSTLVIYN----LLDESEEPFIIRRLS-PGDTTTSIEFVESAVFSVTNRDGYYV-FIEL-----TKNRLSYKVLHSNKMMKGFLEGAFFNSKGEYITYGFKSSLFYLYNETNCYELASEVCGGSHRLWNLADGHVLMYIKASRFHLRKIYNSIVPETLENGVHGREIRDISICNTNTNDNFKDGHIFCTASEDTTIKLGYFRTGKVQNFWTQRKHVSGLQRCQFIHKLMISSSAREELFLWELNDKYRPYMTIRQALPVSDLRIMDFDVKFIDFLLVTVYSDSTIKIWHYRE----NQNKFDLIMQGRYKT--CCLFNVVFIALKELLVVISPTDGHLVVYNSVDPISGDLVPVAQLPVHGVKSLDYVSATILTGGDDNGLGLSNLKLDNKVTLKTSDFAASTITSGMLINGGKEVITSVDQVIRAWEITAG---------------------KLSLVD
4	4ruqA	0.15	0.02	0.81	1.03	HHsearch		----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDCTVIDG-----NLKQIDAG-----SG-SVVGVNNLNETFVLIDNV----FTKISGS----LKHFSVGPAGQLGVNTANNIFKYQ-------SGGFVQLAG------LLKQVDAGDQIIAGVNMYDDIYCLNMDANNKWPSSNTPWVQLNG-------KLKYYSCGPY--SCWGVNSNDQIFIMKDVSSNVCSGSSFINIPG-LLSMIEVADGSVFGVNSQGNLYQRTGVTRSKPDGTDWISMACPNGHKHVFDLGVLWLVCVDGSIRKCIL------------------------------
5	6jp6A	0.11	0.07	2.60	1.26	MUSTER		------------------------------MKDLSHYALCVKFYNDYVLAGYG-PFIHVYDYHSATLINKCRLFHYNKVHGLSLSS--GKILAYGAR--SVTIVELEDVLKKESL----VDFERINSDWITGATFSFDNLQIYLLTCYNKVLICDL--NCEVLFRKSLGGERSIIKVFGPDKVYVNAGTVMGGVIIWDFSETKIHN-------LGHEGSIFYVNLSNNGRYVASCSDDRIRLWDLE-TGKQLSVGW----------------------TARIW-------NLMFFDNDSKLISVSECTCRVWNIINVAELSISNLIKSIWGVDVKEMIAVTSGNDGR-LKL-----DLLQLKRHGDEETSFSLDDIAKQCGDIFEKNESIKGFQWFSFGVIAITSLGK----ILKYSDVTKQWKLLLTNEKFNSYPITNGIQTQNIAVFSNNKSDILLIKF-------------------------------SKDSADIIETEEFHLD---------------------ELSKTNNCLVTEYDDDSFLLT-------------------------------------------------------------------------------LQSPNPREKFVCLEISLQNLKIKSKHCFNKPENFSSSCLTSFRNH-----RFSTLV------------------NLLDESEEPFIIRRLSPGD-----------------------------------------------TTTSIEFVEDKDN-----------------------------SAVFSVTNRDVFIELTKNRLSYKVLHSNKMMK-----GFLEGAFFNSKGEYLYNETNCYELASEVCGGSH----------RLWNLAKITDGHVLMYIKASRFHLRK-IYNSIVPETLENGVHGREIRDISIDGHIFCTASEDTTIKLGY-FNNR--TG-KVQNFWTQRKHVSGLQRCQFINHKLMISSSAREELWELNDKYNKRP----------YMTIRQALPV------------------DLRIMDFD-----VKFISQSGDFLLVTVYSDSKIWHYRENQNKFDLIMQGRYK--CCLF---IALKEELLVVISP----TDGHVVYNITEYVPFSVDPISGDDHKLDATISNLPAPVAQLPVHQSGVKSLD--------------------ATRT-----SATILTGG-NGLGLSNLKLD-------------DSNKVTLKTSDFIAAAASS-TITSGMLINGGKEVITTSVDQVIRAWE-ITAG--VDKKRTTVADTGSLEIISNSEKTLLIGGVGSIWKK---------------------------------------------------------------------------
6	5nrlP	0.11	0.07	2.66	1.53	SPARKS-K		---------------------------AKDDELYLYHLTLKKQTNQLCVATETH--LELYDTADGELKLIAKQNLFATITSMKSLDLPPTFLALTSDSGNLSIVQIIMHA--GALRLKTLVNQPLTRTVSPIMEIDPNGRCIILSSVEQNKLCFLVDYAQKLISSPLEIIRPHMMAVVDFNNPCFVTLEISVHLIFYVGLNHIVKKADYLVNPSANF-VLSLPDLSRYFNPFVVIGFENHILVKDM---------------NGFFSLKVEIPKRSITNSRHKNV------TIISGIVNDVLLQSNHGDLFKLTVSPLVQLSYFDTIQNSHQLHIFNGYLFALSEMNNNFLFQFEKLGVE---------------------KNDFSNVLTSKDPNKSLVFEPSIKLQNSILSQQLNLNPSIKSQIVSDSP-------------LSIATKHFTNNKIITLTN--------------------AVNYSNLISTSLPPNATKL-------------WLIPDPATTGDNNTLLFITFP----------KKTMILQIDNE-----SMEELFKLSQDTT--------------------------------------------------------------------------------------------------------------IHTCLMGSHSTAELRHIVPTGKSRYSNKLTWVP------------------------------PAGIR--------------------------------------------------------------IVCATSSKTQLIISLSNYELVYFKIDVSSDSLIELDTMPSKVAIVQADLLAIADNEGMIKIMSLDFLTVISLQLVSEKISDMIMVRDIGQLNLHVGLNGVYMKFHIGDVDGSFTDIKRRFLPVSLSYLREISSCVVCHSSSTWVSYTWKRQLKDQNMLSCSKFVNADVAIN--GVCSISSSGRLNIGRVS------------NFPTLDNWFHVHEM------------------------------------------LQISTFRPRTILSFPNLFIDNHSKQCRISLQICL--KFGSSDHLYKILDDIDCVSAAIIDF-TRQADHLIICAGDKRLLTYKILVNKELLHQTEI--ISPIHAMLKFKNLLTAMGS--TIVLYGLGKK-----QLLRSVTQTPVSIKIVSMHQNYERLAVGDHESVTLFIWDPAGNV-------FIPYVDDSVK--RHVTVL-KFLDEATVIGADRYGNAWTLRSPPGAIKYKFKFQ-----LLNHFFVNDITDFHILDSL-------SNSDRPG------------CIYMGLQGTVGCFIPLLNIENIMAEADDYESRKKNNICEGSCSILGRDHQEYRS
7	4a08A	0.13	0.08	2.65	3.36	CNFpred		---------------------------------------------NLLIAKNTRLEIYVVTAELRPVKEVGMY---GKIAVMELFR-SKDLLFILTAKYNACILEYKQ------IDIITRAHGNVQ-ETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLPTICFVYQDGRHVKTYAV-SMVIAVP-------EPFGGAIIIGQIKQSTIVCHNR-NGSRYLLGDMEGRLFMLLLEK-----TLKDLRVELLGET-----------SIAECLTYLDNGVVFVGSRGDSQLVKLNYVVAMETFTNLGPIVDMCVVDGQLVTCSGAGSLRIIRNGI---------IHEHASIDLPGIKGLWPL-------------------------------------------SDPNR--------------------ETDDTLVLSFV-----------------------------------------------------------------------------------GQTRVLML--------------------------------------------------------------------------------------------------------------------------VEETELMGFVD----------------------------------------QQTFFCGNVAHQQLIQITSASVRLVSQE------------------------------------------PKALVSEWKEPQA--KNISVASCNSSQVVVAV-GRALYYLQIHLRQISHTEMEHEVACLDITPLSPLCAIGLW-TDISARILKLPSFELLHKEML-RSILMTTFESSHYLLCALGDGALFYFGLN-LLSDRKKVTLGQPTVLRTFRSLTTNVFACSDRPTVIYSSN--------HKLVFSNVNLK-EVNYMCPLNSDYPDSLALANNSTLTIGT-IDEIQKL----HIRTVPLYESPRKICYQESQCFGVLSSRIEVQ-----RPSASTQ-----------ALSSSVS-VHNLLIIDQFEVLHAHQF-EYALSLVSCKL------DPNTYFIVGTAMPKQGRIVVFQYSDGKLQTVA-------EKEVK----GAVYSMVEFNGKLLASI-NSTVRLYEWTT----EKELRTECNHY--NIMALYLKTKGDFILVGDLRSVLLLAYKPM---EGNFE--EIARDFN----PNWMSAVEILD-DDNFLGAENAFNLFVCQKD---HLQEVGLFHLG-EFVNVFCHGS-SVLFGTVNGMIGLVTSLS-----------------------------------------------------------------------
8	5ifeA	0.13	0.09	3.25	1.50	SPARKS-K		------------------------------VDMFLYNLTLQRATGQEIVVSRGK-ILELLRPDPNTG-KVHTLLTVEVIRSLMAFRLTKDYIVVGSDSGRIVILEYQPS----KNMFEKIHQETFGKSIVPGLAVDPKGRAVMISAIEKQKLVYILNRDRLTISSPLEAHKANHVVGVDVGNPMFACLETQQTLTFYEGLNHVVRKYSEPL----EEHGNFLITVPGGSD------GPSGVLICSEN------YITYKNF--GDQPDIRCPIPRRR---NDLDDPERGM-IFVCSATMFFFLAQTEQDIFKITLVTEIRLKYFDTVPVAAAMCVLKGFLFVASEFGNLYQIAHLGDDDEEPE------------------------FSSAMPLEDTFFFQPRPLKNLVLVDELDSLSP--------------------ILFCQIADLANEDTPQLYVACG------------------RGPRS--------------------------------------------------------------SLRVLRHGLEVSEMAVSEL----------------------------------------------------------------------------------------------------------------PGNPNAVWTVRRHIE-DEFDAYIIVSFVN--------------------ATLVLSIGETVEEVTDSGFLGTTPT------LSCSLLGDDAYPDGIRHIRADKRVNEWKTPG----------------------KKTIVKCAVNQRQVVIALTGGELVYFEMPSGQLERKEMSADVVCMSLANSRFLAVGLVDNTVRIISLDP---------SDCLQQPESLCIVEMYLNIGLQNGVLLRTVVTTGSRPV-KLFRVRMQGQEAVLAMSSRSWLSYSYQRFHLTPLSYETLE------FASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQVAFPLQYTIHPESNNLIIIETDHNAYTE----ATKAQRKQQMAEEMVEMAAAFLNE------NLPESIFGAPKAGNGSVIRVMNPIQLVQL-EQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRS-----VAGGFVYTYKLVNNGEKLELHKTPVEEVPAAIAPFQGVLIGVGK--LLRVYDLGKKKLL----RKCENKHIANY-ISGIQTIGHRVIVSDVQSFIWVRYKRNENQ-------LIIFADDTYP--RWVTTASLL-DYDTVAGADKFGNICVVRL-PPNTNASQK------AEVIMNYHVGETV-------LSLQKTTLIPG-----------GSESLVYTTLSGGIGILVPDHDFFQHVEMHLRSEHPPLCGRDHLSFRSYYFPVKNVID
9	6n8pA	0.12	0.07	2.31	1.20	MUSTER		----RDLFQFNK-------------TVEHGFPH-QPSALGYSPSLRILAIGTRSGAIKLYGAPGVEFMGLH--QENNAVTQIHLL-PGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFTLRGPATQITVVLPHSSCELLYLGTESGNVFVVQLPAFRALEDRTISSRVFEMVEALQEHPNQILIGYSRGLVVIWDQGSRVLYH------FLSS-QQLENIWWQRDGRLLVSCHSDGYCQWPVSSE-------------AQQPEPLRSLVPYGPFPCKAITR------ILWLTTRQG---------------LPFTIFQGGMPRASY----GDRHCISVIHDGQQTAFDFTSRVIGFTVLTEADPAA-------------------------TFDDPYALVVLA-EEELVVIDLQTA-GWPPVQLPYLASLHCSAITCSHHVSNIPLKLWE----------------------------------RIIAAGSRQNAHFSTMEWPIDGGT------SLTPAPPQRDLLLTGHEDGT---DASGVCLRLLYKLSTVRVFLDEWPPLRKVGSFDPYSDDPRLGIQK---------------------------CKYSGY--------------------------GTAGQV---------------------------------LNDEAAEQAVEQVEADLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFV-----------------------------------------------------------------------LVQCQPPAVVTSLALHS------EWR-----------------------LVAFGSHGFGLFDHQQRRQVFVKCTLHPSDQLSF----TGFVRTLYFADTY---------------LKDSSRH------------------CPSLWAGTNGGTIYAFS-LRVPPAERR-----MDEPVRAEQAKEIQLMHRAPVVGIL----VLDGHSV-----------------------------------------PLPEPLEVAHDLSKS----PDMQGSHQLLVVSEEQFKVFTKVSAKLKLKLT-----------ALEGSRVRRVSVAHF---GYGEHHLAVLTNLGDIQVVSLPLLKP--VRYSCIRREDVSGIAS-----CVFTKYGQGFYLI-SPS-----------------FERFSLSTKWLVEPRCLVDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10	5hy7A	0.11	0.08	2.70	1.46	SPARKS-K		-------------------------------NMFLYSLTIQPPTQQIITASGSR--LTLLQPDPRQG-KVNTIVSHDIIRAMAAFRLAKDYIILATDSGRIAIIEYLPK----ENRFQRIHLETFGKSVIPGLAADPKGRACLIASVEKNKLVYVLNRNELTISSPLEAHKPGVALDVGYSNPVFAALEYEMQLVYYEGLNHVVRKWSDTVDPTSSL---LFQVPGGNDGPGVLVCGEENITYRH-----------------SNQEAFRVPIPRRRGATEDPNRKRT----IVAGVMAFFFLLQTEDDLFKVTIDKRVKIKYFDTVPIAHSLCILKSFLFVASEFGNFYQFEKLG--------DDDDEPEFTSDDFPADWNAPYNPVYFK-PRPLENLVLVESIDSMNPLVGCKVANLTGEDAPEVSEIVASELPGTPSAVWTTKLTKYDEYDAYIVLSFT-----------------------------------------------------------------------------------NATLVLSIGETV-----------------------------------------EEVSDSGF-------------------------------------------------------------------------------------------------------------------------------------------------LTTVPTLAVQQMGEEGHPKGIRHIVQGRVNEWPAPQHRS-----------------------IVAATTNENQVVIALSSGEIVYFEMDAEYDEKKQMSGTVTSLSLGKSSFLAVGCDDCTVRILSLDPLEMKSIQALTAAPSSLLIMSMEDSYLHIGLHSGVYLRTVLDEITGELTDTRQKFLPTKLFQVTVQNTCVLALSSRPWLGYTAPITRNF----VMTPLSYTELGYTWSFGMVGIHANYLRIFTLGQTMIQKSTYTPKRVKHPEQPYFYVIEADNNTLPP------------------ELPPEDFG----------YPKARGRWA----SCIEIVDPVSE-------------EQPRVLKRIELEGNEAAVSAAVSQDGESFLIVGTTEGAIHVYRFIDEFIHKTIIEEP----PLAFCPFQGLLAGIGK--MLRIYDLGLK-----QLLRKAQAEVSPQLIVSLDTRHNRIVVGDQHGMTYVVYKPDSNK-------LIPFADDTIARWTTCTTMV---DYESVAGGDKFGNLWIVRC-PERASAPNRLD-----LMAHFYPQDLP--------TSICKTNLVVG-----------GQDVLVWSGIQGTVGVLIPFVNLESHMRAEDPPLAGRDHLIYRGYYVPVKGVIDGDLC


(a) ID1 is the number of template residues identical to query divided by number of aligned residues.
(b) ID2 is the number of template residues identical to query divided by query sequence length.
(c) Cov is equal the number of aligned template residues divided by query sequence length.
(d) Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment and is highlighted in bold.
(e) Download alignment lists the threading program used to identify the template, and provide the 3D structure of aligned regions of threading templates (threading[1-10].pdb.gz).
(f) Template residues identical to query sequence are highlighted in color.

Top 1 final models from D-I-TASSER

Rank^a	Estimated TM-score^b
1	0.3107


(a) D-I-TASSER simulations generate a large ensemble of structural conformations, i.e. decoys. These decoys are clustered by SPICKER based on pairwise structure similarity to report up to five final models from the five largest clusters. Models are ranked in descending order of cluster size. If the simulations converge well, it is possible to have less than 5 models generated, which is usually an indication of good model quality.
(b) The model confidence is quantitatified by estimated TM-score (eTM-score), calculated based on significance of threading template alignments, contact map satisfaction rate, mean absolute error between distance of model and distance of AttentionPotential, and convergence of D-I-TASSER simulations. eTM-score is typically in the range of [0, 1], with higher eTM-score signifies higher model confidence.

Proteins with similar structure

Top 10 structural analogs in PDB (as identified by TM-align)


Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.
1	6jp6A	0.65	2.60	0.089	0.672
2	5hy7A	0.41	5.50	0.069	0.473
3	7abhE	0.41	5.45	0.093	0.471
4	5nrlP	0.40	5.89	0.069	0.477
5	5lqwX	0.39	5.64	0.066	0.462
6	3ei2A	0.39	5.47	0.087	0.460
7	6p2kA	0.39	4.85	0.093	0.443
8	5m11A	0.39	5.25	0.059	0.449
9	6eojA	0.39	6.38	0.060	0.468
10	6bllA	0.39	6.01	0.068	0.461



(a) Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d) IDEN^a is the percentage sequence identity in the structurally aligned region.
(e) Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Gene Ontology (GO) Terms

Molecular Function (MF)


GO term	Cscore^GO	Name
GO:1901363	0.63	heterocyclic compound binding
GO:0097159	0.63	organic cyclic compound binding
GO:0003676	0.59	nucleic acid binding
GO:0003677	0.57	DNA binding






(a) Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) The graph shows the predicted terms within the Gene Ontology hierachy for Molecular Function. Confidently predicted terms are color coded by Cscore^GO:

Biological Process (BP)


GO term	Cscore^GO	Name
GO:0009987	0.94	cellular process
GO:0044699	0.81	single-organism process
GO:0065007	0.79	biological regulation
GO:0071840	0.77	cellular component organization or biogenesis
GO:0050789	0.77	regulation of biological process
GO:0016043	0.76	cellular component organization
GO:0008152	0.76	metabolic process
GO:0071704	0.75	organic substance metabolic process
GO:0050794	0.75	regulation of cellular process
GO:0044763	0.75	single-organism cellular process
GO:0044238	0.75	primary metabolic process
GO:0044237	0.74	cellular metabolic process
GO:0043170	0.73	macromolecule metabolic process
GO:0044260	0.72	cellular macromolecule metabolic process
GO:0006996	0.69	organelle organization
GO:0034641	0.68	cellular nitrogen compound metabolic process
GO:0090304	0.67	nucleic acid metabolic process
GO:0048518	0.62	positive regulation of biological process
GO:0048522	0.61	positive regulation of cellular process
GO:0022607	0.61	cellular component assembly
GO:0051128	0.60	regulation of cellular component organization
GO:0048523	0.60	negative regulation of cellular process
GO:0019538	0.60	protein metabolic process
GO:0065008	0.59	regulation of biological quality
GO:0044267	0.59	cellular protein metabolic process
GO:0043933	0.59	macromolecular complex subunit organization
GO:0043412	0.59	macromolecule modification
GO:0007165	0.59	signal transduction
GO:0050896	0.58	response to stimulus
GO:0022402	0.58	cell cycle process
GO:0006464	0.58	cellular protein modification process
GO:1903047	0.57	mitotic cell cycle process
GO:0065003	0.57	macromolecular complex assembly
GO:0051716	0.56	cellular response to stimulus
GO:0051130	0.56	positive regulation of cellular component organization
GO:0043254	0.56	regulation of protein complex assembly
GO:0042981	0.56	regulation of apoptotic process
GO:0034622	0.56	cellular macromolecular complex assembly
GO:0032446	0.56	protein modification by small protein conjugation
GO:0006325	0.56	chromatin organization
GO:0043069	0.55	negative regulation of programmed cell death
GO:0042592	0.55	homeostatic process
GO:0031334	0.55	positive regulation of protein complex assembly
GO:0016570	0.55	histone modification
GO:0016567	0.55	protein ubiquitination
GO:0009411	0.55	response to UV
GO:0007346	0.55	regulation of mitotic cell cycle
GO:0007166	0.55	cell surface receptor signaling pathway
GO:0007154	0.55	cell communication
GO:0006511	0.55	ubiquitin-dependent protein catabolic process
GO:1901987	0.54	regulation of cell cycle phase transition
GO:0090305	0.54	nucleic acid phosphodiester bond hydrolysis
GO:0065004	0.54	protein-DNA complex assembly
GO:0051276	0.54	chromosome organization
GO:0048878	0.54	chemical homeostasis
GO:0043900	0.54	regulation of multi-organism process
GO:0034644	0.54	cellular response to UV
GO:0010498	0.54	proteasomal protein catabolic process
GO:0007267	0.54	cell-cell signaling
GO:1905114	0.53	cell surface receptor signaling pathway involved in cell-cell signaling
GO:1903902	0.53	positive regulation of viral life cycle
GO:1902186	0.53	regulation of viral release from host cell
GO:0198738	0.53	cell-cell signaling by wnt
GO:0051606	0.53	detection of stimulus
GO:0046719	0.53	regulation by virus of viral protein levels in host cell
GO:0045069	0.53	regulation of viral genome replication
GO:0044772	0.53	mitotic cell cycle phase transition
GO:0033683	0.53	nucleotide-excision repair, DNA incision
GO:0033522	0.53	histone H2A ubiquitination
GO:0032508	0.53	DNA duplex unwinding
GO:0010390	0.53	histone monoubiquitination






(a) Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) The graph shows the predicted terms within the Gene Ontology hierachy for Biological Process. Confidently predicted terms are color coded by Cscore^GO:

Cellular Component (CC)


GO term	Cscore^GO	Name
GO:0044464	1.00	cell part
GO:0044424	0.99	intracellular part
GO:0043226	0.96	organelle
GO:0043229	0.87	intracellular organelle
GO:0044422	0.86	organelle part
GO:0044446	0.85	intracellular organelle part
GO:0043227	0.84	membrane-bounded organelle
GO:0043231	0.82	intracellular membrane-bounded organelle
GO:0032991	0.80	macromolecular complex
GO:0044421	0.79	extracellular region part
GO:0043230	0.78	extracellular organelle
GO:0043234	0.77	protein complex
GO:0005737	0.73	cytoplasm
GO:0044428	0.71	nuclear part
GO:0005634	0.71	nucleus
GO:0031988	0.60	membrane-bounded vesicle
GO:0070062	0.59	extracellular exosome
GO:0044427	0.59	chromosomal part
GO:0044444	0.55	cytoplasmic part
GO:1902494	0.53	catalytic complex
GO:1990234	0.51	transferase complex
GO:0005654	0.50	nucleoplasm
GO:0000151	0.50	ubiquitin ligase complex






(a) Cscore^GO is the confidence score of predicted GO terms. Cscore^GO values range in between [0-1]; where a higher value indicates a better confidence in predicting the function using the template.
(b) The graph shows the predicted terms within the Gene Ontology hierachy for Cellular Component. Confidently predicted terms are color coded by Cscore^GO:

Predicted Enzyme Commission (EC) Numbers

Top 5 enzyme homologs in PDB


Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	EC Number	Predicted Active Site Residues
1	0.060	3ecqB	0.255	9.83	0.031	0.387	3.2.1.97	80
2	0.060	2pffD	0.239	10.20	0.021	0.378	2.3.1.86	NA
3	0.060	2vdcA	0.260	10.49	0.044	0.417	1.4.1.13	NA
4	0.060	2qf7B	0.185	9.09	0.043	0.269	6.4.1.1	NA
5	0.060	1bxrA	0.260	9.28	0.040	0.381	6.3.5.5	NA



(a) Cscore^EC is the confidence score for the Enzyme Commission (EC) number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b) TM-score is a measure of global structural similarity between query and template protein.
(c) RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d) IDEN^a is the percentage sequence identity in the structurally aligned region.
(e) Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted Ligand Binding Sites

Template proteins with similar binding site:


Rank	Cscore^LB	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov.	BS-score	Lig. Name	Predicted binding site residues
1	0.01	3i7nA	0.397	5.23	0.080	0.459	0.19	III	39,100,133,290,331,344
2	0.01	2vumA	0.248	10.38	0.027	0.397	0.16	III	147,148,207,208
3	0.01	3cqzA	0.235	9.90	0.042	0.361	0.19	III	174,176,207,241,242
4	0.01	2hgu3	0.061	5.25	0.101	0.072	0.35	III	123,124,125,126,127
5	0.01	2hgu1	0.044	4.29	0.037	0.049	0.22	III	144,189,218



(a) Cscore^LB is the confidence score of predicted binding site. Cscore^LB values range in between [0-1]; where a higher score indicates a more reliable ligand-binding site prediction.
(b) BS-score is a measure of local similarity (sequence & structure) between template binding site and predicted binding site in the query structure. Based on large scale benchmarking analysis, we have observed that a BS-score >1 reflects a significant local match between the predicted and template binding site.
(c) TM-score is a measure of global structural similarity between query and template protein.
(d) RMSD^a the RMSD between residues that are structurally aligned by TM-align.
(e) IDEN^a is the percentage sequence identity in the structurally aligned region.
(f) Cov. represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

References:
1. Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. In preparation, 2020.