Rank | PDB Hit | Iden1 | Iden2 | Cov. | Norm. Z-score | Download Align. | | 20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 | | | | | | | | | | | | | | | | | |
| Sec.Str Seq | CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSSCCCCSSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSCCCC MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV |
1 | 4n6hA | 0.23 | 0.24 | 0.85 | 3.22 | Download | | --------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLM--TWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG----------------------------------- |
2 | 3rzeA | 0.26 | 0.21 | 0.75 | 4.06 | Download | | ----------------------------PLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILG----WNHRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRHM-------------NRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEH----LHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRIL---------------------------------------- |
3 | 4n6hA | 0.23 | 0.24 | 0.85 | 4.13 | Download | | --------------SPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLS---GSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG----------------------------------- |
4 | 2rh1A | 0.22 | 0.25 | 0.81 | 2.64 | Download | | ----------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRTHQEAINCYADFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNL----IRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL-------------------------------------- |
5 | 4iarA | 0.24 | 0.24 | 0.81 | 2.08 | Download | | ---------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQA------SECVVNT-DHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDPGQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-------WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK------------------------------------- |
6 | 2ks9A | 0.21 | 0.24 | 0.99 | 3.97 | Download | | LPVDSDLSPNISTNTSEPQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQ--PRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRLQTQGSVYKVSRLETTISTV |
7 | 4iarA | 0.24 | 0.24 | 0.81 | 3.02 | Download | | --------------YIY-QDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQA------SECVVNTD-HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDDSQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-------WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK------------------------------------- |
8 | 4n6hA | 0.23 | 0.24 | 0.84 | 4.42 | Download | | ----------------GSPGASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGS---KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCG----------------------------------- |
9 | 4iaqA | 0.24 | 0.21 | 0.79 | 3.49 | Download | | ---------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFW------RQASECVVNTD-HILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRII----QKYLLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIH---------LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK------------------------------------- |
10 | 3zpqA | 0.25 | 0.22 | 0.80 | 4.38 | Download | | -----------------GAELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWREDPQALKCCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQ--------SRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDL----VPDWLFVAFNWLGYANSAMNPIIYCR-SPDFRKAFKRLLA--------------------------------------- |
(a) | All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used) |
(b) | Rank of templates represents the top ten threading templates used by GPCR-I-TASSER. |
(c) | Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence. |
(d) | Ident2 is the percentage sequence identity of the whole template chains with query sequence. |
(e) | Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein. |
(f) | Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa. |
(g) | Download Align. provides the 3D structure of the aligned regions of the threading templates. |
(h) | The top 10 alignments reported above (in order of their ranking) are from the following threading programs: |
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1: MUSTER 2: FFAS-3D 3: SPARKS-X 4: HHSEARCH2 5: HHSEARCH I 6: Neff-PPAS 7: HHSEARCH 8: pGenTHREADER 9: wdPPAS 10: cdPPAS |
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