GPCR-I-TASSER results for Q8NGN7

[Click on Q8NGN7_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q8NGN7
MRNHTMVTEFILLGIPETEGLETALLFLFSSFYLCTLLGNVLILTAIISSTRLHTPMYFF
LGNLSIFDLGFSSTTVPKMLFYLSGNSHAISYAGCVSQLFFYHFLGCTECFLYTVMACDR
FVAICFPLRYTVIMNHRVCFMLATGTWMIGCVHAMILTPLTFQLPYCGPNKVGYYFCDIP
AVLPLACKDTSLAQRVGFTNVGLLSLICFFLILVSYTCIGISISKIRSAEGRQRAFSTCS
AHLTAILCAYGPVIVIYLQPNPSALLGSIIQILNNLVTPMLNPLIYSLRNKDVKSDQP

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
MRNHTMVTEFILLGIPETEGLETALLFLFSSFYLCTLLGNVLILTAIISSTRLHTPMYFFLGNLSIFDLGFSSTTVPKMLFYLSGNSHAISYAGCVSQLFFYHFLGCTECFLYTVMACDRFVAICFPLRYTVIMNHRVCFMLATGTWMIGCVHAMILTPLTFQLPYCGPNKVGYYFCDIPAVLPLACKDTSLAQRVGFTNVGLLSLICFFLILVSYTCIGISISKIRSAEGRQRAFSTCSAHLTAILCAYGPVIVIYLQPNPSALLGSIIQILNNLVTPMLNPLIYSLRNKDVKSDQP
PredictionCCCCCCCHHCSSSCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCSSSCCCCCCCCCCHHHHHHHHCHHHCCCCHHHCCCCHHHHHHCC
Conf.Score9988701310132799885089999999999999999989999899971888788489998889998642341388999998606996773899999999999999999999999987508772644457404787499999999999999999999999823789999948885558689988854261099999999999999997999999999999995307652325358762787899699986221037807899875334355777355342013633256588898529

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
MRNHTMVTEFILLGIPETEGLETALLFLFSSFYLCTLLGNVLILTAIISSTRLHTPMYFFLGNLSIFDLGFSSTTVPKMLFYLSGNSHAISYAGCVSQLFFYHFLGCTECFLYTVMACDRFVAICFPLRYTVIMNHRVCFMLATGTWMIGCVHAMILTPLTFQLPYCGPNKVGYYFCDIPAVLPLACKDTSLAQRVGFTNVGLLSLICFFLILVSYTCIGISISKIRSAEGRQRAFSTCSAHLTAILCAYGPVIVIYLQPNPSALLGSIIQILNNLVTPMLNPLIYSLRNKDVKSDQP
Prediction8624130010000000433501100013013313312333310120010013000000100210001001110010020000011543202030020001001300220030001002100000021020002001300000022013201310320030002020036140200000021013000100330022123313330331231023022200000010324622310010000010000012200100000032334321000031033203300300001043126138
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                  
Sec.Str
Seq		CCCCCCCHHCSSSCCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCSSSCCCCCCCCCCHHHHHHHHCHHHCCCCHHHCCCCHHHHHHCC
MRNHTMVTEFILLGIPETEGLETALLFLFSSFYLCTLLGNVLILTAIISSTRLHTPMYFFLGNLSIFDLGFSSTTVPKMLFYLSGNSHAISYAGCVSQLFFYHFLGCTECFLYTVMACDRFVAICFPLRYTVIMNHRVCFMLATGTWMIGCVHAMILTPLTFQLPYCGPNKVGYYFCDIPAVLPLACKDTSLAQRVGFTNVGLLSLICFFLILVSYTCIGISISKIRSAEGRQRAFSTCSAHLTAILCAYGPVIVIYLQPNPSALLGSIIQILNNLVTPMLNPLIYSLRNKDVKSDQP
13v2yA 0.18 0.23 0.86 2.26Download ----------------DKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYK-LTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKN--------NFRLFLLISACWVISLILGG--------LPIMGWNCISA--------LSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRNSRSSENALLKTVIIVLSVFIACWAPLFILLLVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFI
24iaqA 0.16 0.20 0.85 2.37Download ----------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR----WVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISL---------PPCVVNTDH---------------------ILYTVYSTVGAYFPTLLLIALYGRIYVEARSRIIQKYAARERKATKTLGIILGAFIVCWLPFFIISLVMPLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFH
33emlA 0.18 0.22 0.89 3.69Download ------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHI-INCFTFFCPDCSHLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
43uonA 0.18 0.20 0.90 2.57Download ------------------TFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV--GVRTVEDGECYIQFF------S---NAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPNVWTIGYWLCYINSTINPACYALCNATFKKTFK
54bvnA 0.16 0.21 0.90 2.08Download -----------------LQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMH----WWRDEDPQALKCYQD----PGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKE----MREHKALKTLGIIMGVFTLCWLPFFLVNIVNVDLPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFK
63emlA 0.18 0.22 0.89 4.02Download -------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCF-TFFCPDCSHAWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
74bvnA 0.16 0.21 0.90 3.00Download ----------------LSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWW----RDEDPQALKCYQD----PGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQ---MREHKALKTLGIIMGVFTLCWLPFFLVNIVNDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAF-
84ea3A 0.20 0.21 0.84 2.67Download -----------------PLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPTSSKAQAVNVAIWALASVVGVPVAIMGSAQV---------EDEEIEYWGPVFAICIFLFSF-----------------IVPVLVISVCYSLMIRRLRGVRLLSGSVAVFVGCWTPVQVFVLAQGLGV----QPSSTAVAILRFCTALGYVNSCLNPILYAFLDENFKACFR
93emlA 0.18 0.22 0.89 4.94Download ------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHII-NCFTFFCPDCSHAPLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
103emlA 0.18 0.22 0.89 5.41Download IM------------------GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLV-----------PLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWL-PLHIINCFTFFCPDCSHAPLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFQ
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.06 (Read more about C-score)
  • Estimated TM-score = 0.71±0.12
  • Estimated RMSD = 6.3±3.9Å

  • Download Model 2
  • C-score = -1.39

  • Download Model 3
  • C-score = -1.81

  • Download Model 4
  • C-score = -0.53

  • Download Model 5
  • C-score = -0.91




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).