GPCR-I-TASSER results for Q8NGF2

[Click on Q8NGF2_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q8NGF2
MGIPGPEASHFWIAFPFCSMYALAVLGNMVVLLVVHSEPVLHQPMYLFLCMLSTIDLVLC
TSTVPKLLALFWAKDAEINFGACAAQMFFIHGFSAVESGILLAMAFDRYLAICWPLHYGS
LLSPESVGKLGAAAVLRGLGLMTPLTCLLARLSYCSRVVAHSYCEHMAVVKLACGGTQPN
NIYGITAATLVVGTDSICIAVSYALILRAVLGLSSKEARAKTFGTCGSHLGVILLFYTPG
LFSFYTQRFGQHVPRHIHILLADLYLVVPPMLNPIIYGMKTKQIWDGALRLLKWGPAQS

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MGIPGPEASHFWIAFPFCSMYALAVLGNMVVLLVVHSEPVLHQPMYLFLCMLSTIDLVLCTSTVPKLLALFWAKDAEINFGACAAQMFFIHGFSAVESGILLAMAFDRYLAICWPLHYGSLLSPESVGKLGAAAVLRGLGLMTPLTCLLARLSYCSRVVAHSYCEHMAVVKLACGGTQPNNIYGITAATLVVGTDSICIAVSYALILRAVLGLSSKEARAKTFGTCGSHLGVILLFYTPGLFSFYTQRFGQHVPRHIHILLADLYLVVPPMLNPIIYGMKTKQIWDGALRLLKWGPAQS
PredictionCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCSSSCCCHHHHHHHHHHHHCCCCCCC
Conf.Score98999466879999999999999999999999999578874423899999999999989986599999999669986788789999999999999999999999823166305665451228889999999999999999998899999608987884861210037568882578358789999999999999899999999999999836888758889865049999999999999999974752158888479999999998488764782220547999999999966686899

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
MGIPGPEASHFWIAFPFCSMYALAVLGNMVVLLVVHSEPVLHQPMYLFLCMLSTIDLVLCTSTVPKLLALFWAKDAEINFGACAAQMFFIHGFSAVESGILLAMAFDRYLAICWPLHYGSLLSPESVGKLGAAAVLRGLGLMTPLTCLLARLSYCSRVVAHSYCEHMAVVKLACGGTQPNNIYGITAATLVVGTDSICIAVSYALILRAVLGLSSKEARAKTFGTCGSHLGVILLFYTPGLFSFYTQRFGQHVPRHIHILLADLYLVVPPMLNPIIYGMKTKQIWDGALRLLKWGPAQS
Prediction77134245202000231330222033212100000101430020002000200110100020130300000004246030500000011013113311000100030000000210200000023000100010122110112111200310210331010000102200300021030013203320333333333203301120020003011660232001000000000201331132100002113312330100000200230133003000020330141024004435668
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   
Sec.Str
Seq		CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCSSSCCCHHHHHHHHHHHHCCCCCCC
MGIPGPEASHFWIAFPFCSMYALAVLGNMVVLLVVHSEPVLHQPMYLFLCMLSTIDLVLCTSTVPKLLALFWAKDAEINFGACAAQMFFIHGFSAVESGILLAMAFDRYLAICWPLHYGSLLSPESVGKLGAAAVLRGLGLMTPLTCLLARLSYCSRVVAHSYCEHMAVVKLACGGTQPNNIYGITAATLVVGTDSICIAVSYALILRAVLGLSSKEARAKTFGTCGSHLGVILLFYTPGLFSFYTQRFGQHVPRHIHILLADLYLVVPPMLNPIIYGMKTKQIWDGALRLLKWGPAQS
13uonA 0.18 0.18 0.90 2.04Download ---------VVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQ-FIVGVRTVEDGECYIQFFS---------NAAVTFGTAIAAFYLPVIIMTVLYWHISRAS----KSRREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL-------
24iaqA 0.15 0.18 0.89 1.80Download YQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG----RWVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP-------PFFWRQASE-------------CVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIMAARERKATKTLGIILGAFIVCWLPFFIISLVMPI-----HLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK----
33emlA 0.17 0.24 0.93 2.71Download -----IM-GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGGQVACL-----------FEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFC---PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
44bvnA 0.18 0.23 0.94 2.55Download -----LSQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRD---EDPQALKCYQDPG----CCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA------
54bvnA 0.18 0.23 0.92 2.08Download -----LQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWW-R--DEDPQALKCYQD----PGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKE----MREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA------
63emlA 0.17 0.24 0.92 3.04Download --------GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGGQVACLFEDVV-----------PMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFC---PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
74bvnA 0.18 0.23 0.93 3.03Download -----LQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRD---EDPQALKCYQDP----GCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQ---MREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA------
84buoA 0.15 0.21 0.96 3.03Download LDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGGTHPGGLVCTPIV------DTATLKVVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFCYISHYFYMLTNALVYVSAAINPILYNLVSANFRQVFLSTL-------
93emlA 0.17 0.24 0.92 3.37Download -----I--GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISF----CAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPML--------WNNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFF-----DCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
103emlA 0.16 0.24 0.93 3.95Download IMG------SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGGQVACLFEDVVPMNYMVYFNFFACVL-----------VPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLP-LHIINCFTFF--CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=0.52 (Read more about C-score)
  • Estimated TM-score = 0.78±0.09
  • Estimated RMSD = 5.1±3.3Å

  • Download Model 2
  • C-score = 0.53

  • Download Model 3
  • C-score = -4.99

  • Download Model 4
  • C-score = -4.13

  • Download Model 5
  • C-score = -3.21




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).