GPCR-I-TASSER results for Q86SF3

[Click on Q86SF3_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q86SF3
MSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMY
FFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMTY
DRYVAICHPLHYTVIMREELCVFLVAVSWILSCASSLSHTLLLTRLMSPENQSSVSEFLL
LGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFS
SVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMAYDRYVAICHPLHYTV
IMREELCVFLVAV

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
MSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMTYDRYVAICHPLHYTVIMREELCVFLVAVSWILSCASSLSHTLLLTRLMSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMAYDRYVAICHPLHYTVIMREELCVFLVAV
PredictionCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCSCCCHHHHHHHHCC
Conf.Score9998886066777527998832658999999999999999999999999668875554999988899986626622789998998558971402337999999999998999999999875066417753376016752799999999999999999998776763445568751657643599974458999999999999999999999999982466666499998899999888524208998788753797456764899999999999999999999876315402775318720776388786339

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
MSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMTYDRYVAICHPLHYTVIMREELCVFLVAVSWILSCASSLSHTLLLTRLMSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMAYDRYVAICHPLHYTVIMREELCVFLVAV
Prediction8656230200000000005325211000130130122013323100100000130000001002000120312100320300200215433020300200110010002100000000000000000200211010012000000220000000100010000020023332230011000000132620100013113113213322310010000133001000000101011021313131030020020653301130020021000000100000000000000000020020002002200100023
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |             
Sec.Str
Seq
CCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCSCCCHHHHHHHHCC
MSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMTYDRYVAICHPLHYTVIMREELCVFLVAVSWILSCASSLSHTLLLTRLMSPENQSSVSEFLLLGLPIRPEQQAVFFTLFLGMYLTTVLGNLLIMLLIQLDSHLHTPMYFFLSHLALTDISFSSVTVPKMLMDMRTKYKSILYEECISQMYFFIFFTDLDSFLITSMAYDRYVAICHPLHYTVIMREELCVFLVAV
14dajA 0.13 0.17 0.79 2.01Download -----------------------VVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGE-----CFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETAQT---------LSAILLAFIITWTPYNIMVLVN---TFCDSCIPKTYWNLGYWLCYINSTVNPVCY---------------------------
24iaqA 0.16 0.19 0.86 1.73Download ------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR----WVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLP-------PFFWRQASE-----CVVNTDHILYTVYSTVGAYFPTLLLIALYGRIYVEARSRILMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIH--------LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK---------
33emlA 0.18 0.20 0.84 2.39Download --------------------IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQGCGEGQVACL----FEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAAAKSLAIIVGLFALCWLPLHIINCFTFF------PDCSHAP-----LWLMYLAIVLSHTN-------------VVNPFIYA-YRIREFRQTFRKI
44iarA 0.17 0.22 0.87 2.34Download -----------YIY-QDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF-WRQA---------SECVVN-TDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADAARERKATKTLGIILGAFIVCWLPFFIISLVMPI--------WFHLAIFDFF---TWLGY-------LNSLINPIIYTMSNEDFKQAFHKLI
54bvnA 0.14 0.18 0.84 1.70Download -------------------SQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHW----WRDEDPQALKCYPGCCDFVTNRAISFYIPLLIMIFVALRVYREAKE-----REHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNR--DLV-----PKWLFVAFNW----------LGY--ANSAMNPIILC--RSPDFRKAFKRL
63emlA 0.18 0.20 0.85 2.83Download ---------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGE--GQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNS----------------------VVNPFIY-AYRIREFRQTFRKI
74buoA 0.14 0.16 0.90 2.34Download -----NSD------LDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKS---TVDYYLGSLALSDLLILLLAMPVELYNFIHHPWAFGDAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPG-GLVCTIVDTATLKVVIFMSFLFPMLVASILNTVIANKLTVQPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMISDEQWTTFLFFLTNALVYVSAAINPILYNLVSANFRQVFLSTL-----------------
84buoA 0.14 0.16 0.92 2.45Download ----NSD-------LDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSTVDYYLGSLALSDLLILLLAMPVELYNFIWVHHPWAFAGCRGYYFLRDACTYATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPGLVCTPIVDVIQVNTFMSFLFPMLVASILNTVIANKLTVMVHQPGRVQALRRGVLVLRAVVIAFVVCWLPLMFCYISDEQWT------------TFLFDFYHYFYMLTNALVYVSAAINPILYNLVSRQVFLSTL---
93emlA 0.19 0.20 0.85 2.81Download -------------IM-------GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGEGQ--VACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQL--VHAAKSLAIIVGLFALCWLPLHIINCFTDCSHAP-----LWLMYLAIVLSHTN--------------VNPFIYA-YRIREFRQTFRKI
103emlA 0.19 0.20 0.81 2.91Download I--------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGEVVPMNYMVYFNFFACVLVPLLLMLGVYL-------RIFLAA-----RRQLIIVGLFALCWL-PLHIIN----CFTFFCPDCSHAP-----LWLMYLAIVLSHTNSVVNPFIYAR--------------IREFRQTFRKI
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.38 (Read more about C-score)
  • Estimated TM-score = 0.66±0.13
  • Estimated RMSD = 7.1±4.2Å

  • Download Model 2
  • C-score = -1.70

  • Download Model 3
  • C-score = -2.97

  • Download Model 4
  • C-score = -3.66

  • Download Model 5
  • C-score = -3.44





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).