GPCR-I-TASSER results for Q7Z5H5

[Click on Q7Z5H5_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q7Z5H5
MASRYVAVGMILSQTVVGVLGSFSVLLHYLSFYCTGCRLRSTDLIVKHLIVANFLALRCK
GVPQTMAAFGVRYFLNALGCKLVFYLHRVGRGVSIGTTCLLSVFQVITVSSRKSRWAKLK
EKAPKHVGFSVLLCWIVCMLVNIIFPMYVTGKWNYTNITVNEDLGYCSGGGNNKIAQTLR
AMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHIDRSDLSPRASPENRATQSILILVS
TFVSSYTLSCLFQVCMALLDNPNSLLVNTSALMSVCFPTLSPFVLMSCDPSVYRFCFAWK
R

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MASRYVAVGMILSQTVVGVLGSFSVLLHYLSFYCTGCRLRSTDLIVKHLIVANFLALRCKGVPQTMAAFGVRYFLNALGCKLVFYLHRVGRGVSIGTTCLLSVFQVITVSSRKSRWAKLKEKAPKHVGFSVLLCWIVCMLVNIIFPMYVTGKWNYTNITVNEDLGYCSGGGNNKIAQTLRAMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHIDRSDLSPRASPENRATQSILILVSTFVSSYTLSCLFQVCMALLDNPNSLLVNTSALMSVCFPTLSPFVLMSCDPSVYRFCFAWKR
PredictionCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCSSSSSSSSHHHHCCHHHHHHHHHHHHHCSSSCCCCHHHHHHHHHCCCSSHHHHHHHHHHHHHHHCCSSSSSSCCCCCCCCCCCCCCCSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCHHHHHCCCCCCCHHCSSSSC
Conf.Score9867888865299998999999999999999998288889389999999999999999987999999957622278881699988788756057999999998551898689748766436457865899999999999986052489974886631364356717897268278999999999999999999999988899999999899860660888999998799999999999999999998899999999993689815531999997650564846642489863014013669

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MASRYVAVGMILSQTVVGVLGSFSVLLHYLSFYCTGCRLRSTDLIVKHLIVANFLALRCKGVPQTMAAFGVRYFLNALGCKLVFYLHRVGRGVSIGTTCLLSVFQVITVSSRKSRWAKLKEKAPKHVGFSVLLCWIVCMLVNIIFPMYVTGKWNYTNITVNEDLGYCSGGGNNKIAQTLRAMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHIDRSDLSPRASPENRATQSILILVSTFVSSYTLSCLFQVCMALLDNPNSLLVNTSALMSVCFPTLSPFVLMSCDPSVYRFCFAWKR
Prediction5523200111033133333322220031100000344331111000100131012102013312000000231223122001000100011110000000000200000013222023022302200011001213210212130002030333331333333210010123433110011001122113110011001000000011123203323324224333212100100000002013103310310000110334210010011030131121000000122420210112037
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
Sec.Str
Seq		CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCSSSSSSSSHHHHCCHHHHHHHHHHHHHCSSSCCCCHHHHHHHHHCCCSSHHHHHHHHHHHHHHHCCSSSSSSCCCCCCCCCCCCCCCSSSSSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCHHHHHCCCCCCCHHCSSSSC
MASRYVAVGMILSQTVVGVLGSFSVLLHYLSFYCTGCRLRSTDLIVKHLIVANFLALRCKGVPQTMAAFGVRYFLNALGCKLVFYLHRVGRGVSIGTTCLLSVFQVITVSSRKSRWAKLKEKAPKHVGFSVLLCWIVCMLVNIIFPMYVTGKWNYTNITVNEDLGYCSGGGNNKIAQTLRAMLLSFPDVLCLGLMLWVSSSMVCILHRHKQRVQHIDRSDLSPRASPENRATQSILILVSTFVSSYTLSCLFQVCMALLDNPNSLLVNTSALMSVCFPTLSPFVLMSCDPSVYRFCFAWKR
14phuA 0.13 0.18 0.86 1.92Download ---PQLSFGLYVAAFALGFPLNVLAI--RGATAHARLRLTPSAVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAARYLGAAFPPCYSWG-----------VCAAIWALVLCHLGLVFGLEAPGTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCFVGCLRALAR-----------GGSLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVT----------------
24phuA 0.12 0.18 0.88 1.63Download DLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRL--TPSAVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFAPLYAGGGFLAALSAARYLGAAPP-----CYSWGVCAAIWALVLCHLGLVFGLEAPGG-----WLDHSNTSLGINSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCFVGCLRALAR-----------GGSLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLG------------
34grvA 0.11 0.20 0.91 1.38Download IYSKVLVTAIYLALFVVGTVGNSVTLFTLAR-----KSLQTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAIC---HPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGL-VCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVM------------SGSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQWYFYMLTNALAYASSAINPILYNLVSANFRQV------
43uonA 0.12 0.20 0.94 2.51Download -TFEVVFIVLAGSLSLVTIIGNILVMVSIKV---NRHLQTVNNYFLFSLACADLIIGVFS-MNLYTLYVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFYFCVT-KPLTYP----VKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRT----VEDGECYIQFFSNA--AVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINIFEMLELKDAYPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPIPNTVWTIGYWLCYINSTINPACYALCNATFKK-TFKM--
54grvA 0.11 0.21 0.94 2.01Download TDYSKVLVTAYLALFVVGTVGNSVTLFTLA----RK-LQSTVHYHLGSLALSDLLILLL-AMPVELYNFHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAICPFKAK----TLMSRSRTKKFISAIWLASALLAIPMLFTMGLQN-RSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMVNIFEMLRRNYGSGSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDE-QWFYMLTNALAYASSAINPILYNLVSANFRQV------
64grvA 0.09 0.20 0.91 1.65Download IYSKVLVTAIYLALFVVGTVGNSVTLFTLAR----KSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWHPWAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAIC---HPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGL-QNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMS------------GSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQHYFYMLTNALAYASSAINPILYNLVSANFRQV------
74iarA 0.12 0.21 0.91 2.83Download SLPWKVLLVLLALITLATTLSNAFVIATVY---RTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKR---AAVMIALVWVFSISISLPPFF-WRQA------SE------CVVNTDH-I--LYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIADLEDLPDSPQKYLAARERKATKTLGIILGAFIVCWLPFFIISLVMPI--WFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQIRFK---
84n6hA 0.17 0.23 0.92 2.19Download LALAIAITALYSAVCAVGLLGNVLVMFGIVRY----TKMKTTNIYIFNLALADALATST-LPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVK---ALDFRTPAKAKLINICIWVLASGVGVPMAVTRPRD----------GAVVCMLQFPSYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSV-----RLLSGS-KEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCR
94grvA 0.11 0.20 0.90 1.42Download IYSKVLVTAIYLALFVVGTVGNSVTLFTLA-----RKSLQTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAIHPFKAK-----LMSRSRTKKFISAIWLASALLAIPMLFTMG--QNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVM------------SGSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQHYFYMLTNALAYASSAINPILYNLVSANFRQV------
104mbsA 0.13 0.23 0.94 1.54Download KINVKQIAARLLPPLIFGFVGNMLVILILIN---YKRLKSMTDIYLLNLAISDLFFLLT--VPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVH---AVFALKARTVTFGVVTSVITWVVAVFASLPNIIFTRSQKEGLHY-------TCSSHFPYSQYQFWKNFQTLKIVILGLLVMVICYSGILKTLLRDFKDIPDDWVCPLVEEEKKRHRDVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTEPIIFVGEENYLLVFF----Q
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.12 (Read more about C-score)
  • Estimated TM-score = 0.70±0.12
  • Estimated RMSD = 6.5±3.9Å

  • Download Model 2
  • C-score = -2.75

  • Download Model 3
  • C-score = -1.47

  • Download Model 4
  • C-score = -2.48

  • Download Model 5
  • C-score = -5




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).