GPCR-I-TASSER results for Q6IFK7

[Click on Q6IFK7_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q6IFK7
MMTVILKTLLGQIQGLSGNPHSTTSRMYFLCFCTSLLGFKVHWVSRLIKLYMASPNNDST
APVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLL
SLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQMFIMNSFLTMESCTFMVMAYDRYVAI
CHPLRYPSIITDQFVARAVVFVIARNAFVSLPVPMLSARLRYCAGNIIKNCICSNLSVSK
LSCDDITFNQLYQFVAGWTLLGSDLILIVISYSFILKVVLRIKAEGAVAKALSTCGSHFI
LILFFSTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNL
LKRL

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
MMTVILKTLLGQIQGLSGNPHSTTSRMYFLCFCTSLLGFKVHWVSRLIKLYMASPNNDSTAPVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQMFIMNSFLTMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAVVFVIARNAFVSLPVPMLSARLRYCAGNIIKNCICSNLSVSKLSCDDITFNQLYQFVAGWTLLGSDLILIVISYSFILKVVLRIKAEGAVAKALSTCGSHFILILFFSTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNLLKRL
PredictionCSSSCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCHHHHHHHHHHHHCCCCCCCSSSSCCHHHHHHHHHHHHHCC
Conf.Score9476034755775087789875402567501225544345555987758772486899987353232679999877899999999999999999999988877478875421899999999999999985499999998469986888889999999999999999999999813177416664576128889999999999999999998899999428999989478733200656787247835878999999999999989999999999999981788976878974425999999999999899873302579968828999999999628866468133165799999999998329

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
MMTVILKTLLGQIQGLSGNPHSTTSRMYFLCFCTSLLGFKVHWVSRLIKLYMASPNNDSTAPVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQMFIMNSFLTMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAVVFVIARNAFVSLPVPMLSARLRYCAGNIIKNCICSNLSVSKLSCDDITFNQLYQFVAGWTLLGSDLILIVISYSFILKVVLRIKAEGAVAKALSTCGSHFILILFFSTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNLLKRL
Prediction6020003133340433323343232322321310311332233133123330223314241312101000002234101000130231122023112100000100420010002000100010100000000200000004346030300000012012112200000000020000000210100000033000000000012110111001210200210362101000000220010002203001210222033333332320320111002000302066013200100000000010133213210000114340032010000020013013300300002033014002300434
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
Sec.Str
Seq
CSSSCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCHHHHHHHHHHHHCCCCCCCSSSSCCHHHHHHHHHHHHHCC
MMTVILKTLLGQIQGLSGNPHSTTSRMYFLCFCTSLLGFKVHWVSRLIKLYMASPNNDSTAPVSEFLLICFPNFQSWQHWLSLPLSLLFLLAMGANTTLLITIQLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQMFIMNSFLTMESCTFMVMAYDRYVAICHPLRYPSIITDQFVARAVVFVIARNAFVSLPVPMLSARLRYCAGNIIKNCICSNLSVSKLSCDDITFNQLYQFVAGWTLLGSDLILIVISYSFILKVVLRIKAEGAVAKALSTCGSHFILILFFSTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNLLKRL
14n6hA 0.12 0.19 0.97 1.67Download ALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPS---------PSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIANSSLNPVLYAFLDENFKRCFRQLCRKP
23uonA 0.15 0.14 0.74 1.84Download -----------------------------------------------------------------------------VVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFF-----------SNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRREK----KVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLL---
34iaqA 0.19 0.21 0.74 1.71Download ------------------------------------------------------------------YIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTG--RWTLVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFF--------WRQASE-------------CVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRIMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIHL-----AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK
44ea3B 0.13 0.19 0.94 1.65Download VKDALTKMRAAALDAQKADKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLL-TLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAEIECLVEI--------------PTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLEK---DRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKF----
53emlA 0.16 0.18 0.75 2.19Download -------------------------------------------------------------------------IM-GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACL-----------FEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFC---PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
62rh1A 0.20 0.23 0.77 2.57Download -------------------------------------------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRA----THQEAINCYAEE----TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNKLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL-
74bvnA 0.21 0.20 0.76 2.05Download -------------------------------------------------------------------------LQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMH----WWRDEDPQALKCYQ----DPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKE----MREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA--
83emlA 0.15 0.18 0.75 2.51Download ---------------------------------------------------------------------------MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVV-----------PMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFF---CPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSH
94bvnA 0.21 0.20 0.76 3.05Download -------------------------------------------------------------------------SQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWW----RDEDPQALKCYQD----PGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQ---MREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPKWLFVAFNWLGYANSAMNPIILC-RSPDFRKAFKRLLA--
101u19A 0.17 0.19 0.80 2.62Download ---------------------------------------------------MNGFSNKTGVVRSPFE---APQYPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPP---LVGWSRYCIDYYTPH-------------EETNNESFVIYMFVVH-FIIPLIVIFFCYGQLVFTVKEAAAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSD--FGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCG
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: Neff-PPAS   2: FFAS-3D   3: SPARKS-X   4: Neff-PPAS   5: MUSTER   6: HHSEARCH2   7: HHSEARCH I   8: Neff-PPAS   9: HHSEARCH   10: pGenTHREADER   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-0.85 (Read more about C-score)
  • Estimated TM-score = 0.61±0.14
  • Estimated RMSD = 8.5±4.5Å

  • Download Model 2
  • C-score = -2.26

  • Download Model 3
  • C-score = -4.21

  • Download Model 4
  • C-score = -4.15

  • Download Model 5
  • C-score = -4.16





  •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).