GPCR-I-TASSER results for P34998

[Click on P34998_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>P34998
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
PredictionCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCSSCCCCCCCCCCCCCCSSSCCCCHHHCCCCCCCCCCCSSCCCCCCSSCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHSSSSSSHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHSSSSSSSSSCCCCSSSSSSSSSCCCCCCCCCCCCCCCCCCSSSSCCCSSSHHHHHHHHHHHHHHHCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCHHHHHHHHHHHHHHHHHHHHCSSSSSCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score998998742999999988899999999999998712899999998856797151798999978983696174656567786005348999864787874543332223432001002121244468511188899999999875133220003248899999998633114643105568899999999999999999999987212324688884099999999999999999999999999888887157630121178898632331589999863134444320037975010577327434455313568888575604233455313588999988899999999999988772211567538999999999998877766504678718999999999986334677778887888778899974789988788789

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
Prediction724306141032013202440244114411441354453642201010010100013031223021000200100212232211230222211222021222121222123232222022222220100000000000000000132232122100000000000000000000203320010000000000000000000000000112221200000000000001000000000000000000010022432000000000000110000000002112110000001420000000010000000000000000000000112223324334202100100000001123010000000133210100000000000030011000000002440041024103423454434453334433433434434424444336
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
Sec.Str
Seq		CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCSSCCCCCCCCCCCCCCSSSCCCCHHHCCCCCCCCCCCSSCCCCCCSSCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHSSSSSSHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHSSSSSSSSSCCCCSSSSSSSSSCCCCCCCCCCCCCCCCCCSSSSCCCSSSHHHHHHHHHHHHHHHCSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCHHHHHHHHHHHHHHHHHHHHCSSSSSCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
14k5yA 0.93 0.54 0.56 2.73Download ------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRAR-----------------------------SIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTNIFEMLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVNE----VSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
24k5yA 0.94 0.54 0.56 5.53Download ------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRA-----------------------------RSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTFEYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVN----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
34k5yA 0.94 0.54 0.56 3.20Download ------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRA-----------------------------RSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTFEYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVN----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
44k5yA 0.93 0.53 0.56 3.50Download ------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRAR-----------------------------SIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVNEV----SRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
54k5yA 0.91 0.54 0.55 8.55Download --------------------------------------------------------------------------------------------------------------------HVAAIINYLGHCISLVALLVAFVLFLRA-----------------------------RSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTNIFERLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPYTD--YIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVNEVS----RVVFIYFNAFLESFQGFFVSVFACFLN------------------------------------------------
64k5yA 0.91 0.53 0.55 8.11Download -------------------------------------------------------------------------------------------------------------------YHVAAIINYLGHCISLVALLVAFVLFLRA-----------------------------RSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPYTD--YIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVNEVS----RVVFIYFNAFLESFQGFFVSVFACFLN------------------------------------------------
74k5yA 0.86 0.53 0.56 3.06Download --------------------------------------------------------------------------------------------------------------------------------------------------VAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV---LTDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVNPGEDEVSRVVFIYFNAFLESFQGFFVSVFACFLN------------------------------------------------
84k5yA 0.84 0.54 0.56 4.62Download -----------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTFEYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVN----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
94k5yA 0.83 0.54 0.56 1.39Download -----------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTNIFERLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFV----NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
104k5yA 0.83 0.54 0.56 3.61Download -----------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTNIFEMLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFV----NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS03   2: HHSEARCH   3: HHSEARCH2   4: FFAS03   5: PRC   6: PRC   7: FFAS-3D   8: HHSEARCH I   9: wdPPAS   10: SP3   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1

    Estimated acuracy of domain 1 (1-117)
  • C-score=-0.72 (Read more about C-score)
  • Estimated TM-score = 0.62±0.14
  • Estimated RMSD = 5.7±3.6Å

    Estimated acuracy of domain 2 (118-444)
  • C-score=1.02 (Read more about C-score)
  • Estimated TM-score = 0.87±0.16
  • Estimated RMSD = 4.1±1.3Å




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).