GPCR-I-TASSER results for Q9H2C7

[Click on Q9H2C7_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q9H2C7
MYIVAVAGNIFLIFLIMTERSLHEPLYLFLSMLASANFLLAAAAAPEVLAILWFHSMDIS
FGSCVSQMFFIHFIFVAESAILLAMAFDRYVAICYPLRYTILTSSAVRKIGIAAVVRSFF
ICCPFIFLVYRLTYCGRNIIPHSYCEHMGIARLACGNINVNIIYGLTVALLSTGLDIVLI
IISYTMILHAVFQMSSWAARFKALSTCGSHICVIFMFYTPAFFSFLAHRFGGKTIPHHIH
ILVGSLYVLVPPMLNPIIYGVKTKQIKDRVILLFSPISVCC

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MYIVAVAGNIFLIFLIMTERSLHEPLYLFLSMLASANFLLAAAAAPEVLAILWFHSMDISFGSCVSQMFFIHFIFVAESAILLAMAFDRYVAICYPLRYTILTSSAVRKIGIAAVVRSFFICCPFIFLVYRLTYCGRNIIPHSYCEHMGIARLACGNINVNIIYGLTVALLSTGLDIVLIIISYTMILHAVFQMSSWAARFKALSTCGSHICVIFMFYTPAFFSFLAHRFGGKTIPHHIHILVGSLYVLVPPMLNPIIYGVKTKQIKDRVILLFSPISVCC
PredictionCSSSHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCSSSSCCHHHHHHHHHHHHCCCCCCC
Conf.Score96756766788898884789754328999999999999899854999999995699868887899999999999999999999998130652046641253388899999999999999999989999974899999946871210164688815784476899999999999999999999999999998268887588887541599999999999989999634213789997278999999997388664681221547999999999943577679

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MYIVAVAGNIFLIFLIMTERSLHEPLYLFLSMLASANFLLAAAAAPEVLAILWFHSMDISFGSCVSQMFFIHFIFVAESAILLAMAFDRYVAICYPLRYTILTSSAVRKIGIAAVVRSFFICCPFIFLVYRLTYCGRNIIPHSYCEHMGIARLACGNINVNIIYGLTVALLSTGLDIVLIIISYTMILHAVFQMSSWAARFKALSTCGSHICVIFMFYTPAFFSFLAHRFGGKTIPHHIHILVGSLYVLVPPMLNPIIYGVKTKQIKDRVILLFSPISVCC
Prediction41000132231000001014300200020013001201000101303000000043460304000000110131133110000000300000002101000003320010001012211122311131030032046220100001023003000230300132033203333333332033012200200030216602320110000000002113321321000121243412430100001202231133003000020330141024003434236
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=0.52
 C-score=-0.96
 C-score=-1.18
 C-score=-4.00
 C-score=-1.34
 
Estimated accuracy of Model1: 0.78±0.09 (TM-score)    5.0±3.2Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.
Download estimated local accuracy of Model2, Model3, Model4, Model5

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
Sec.Str
Seq		CSSSHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCSSSSCCHHHHHHHHHHHHCCCCCCC
MYIVAVAGNIFLIFLIMTERSLHEPLYLFLSMLASANFLLAAAAAPEVLAILWFHSMDISFGSCVSQMFFIHFIFVAESAILLAMAFDRYVAICYPLRYTILTSSAVRKIGIAAVVRSFFICCPFIFLVYRLTYCGRNIIPHSYCEHMGIARLACGNINVNIIYGLTVALLSTGLDIVLIIISYTMILHAVFQMSSWAARFKALSTCGSHICVIFMFYTPAFFSFLAHRFGGKTIPHHIHILVGSLYVLVPPMLNPIIYGVKTKQIKDRVILLFSPISVCC
13pblA 0.20 0.22 0.89 1.85Download LILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTG-GVWNFSCCDVFVTLDVMMCTASIWNLCAISIDRYTAVVMPVHYQHGSCRRVALMITAVWVLAFAVSCPLLF--GFNTTCSIS----------------------NPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC-----
22rh1A 0.20 0.25 0.94 2.92Download IVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQLLTKNKARVIILMVWIVSGLTSFLPIMHWYRAT-----HQEAINCYAEE----TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN-LIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL-----
33emlA 0.19 0.25 0.94 2.90Download IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFE-----------DVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFC----PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR-SHVLR
42ydoA 0.18 0.24 0.99 4.06Download IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSAAAADILVGVLAIPFAIAI--STGFCAACHGCLFIACFVLVLTASSIFSLLAIAIDRYIAIRIPLRYGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLF-EDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCAPLWLMYLAIVLSHTNS-VVNPFIYAYRIREFRQTFRKIIRSHVLRQ
53emlA 0.18 0.25 0.94 3.12Download IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL-----------VPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLP-LHIINCFTFFC---PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ
61gzmA 0.14 0.21 0.94 1.88Download LIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYI-------MQCSC---GIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAATQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTL-------
72rh1A 0.20 0.25 0.95 3.32Download IVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLTKNKARVIILMVWIVSGLTSFLPIQMHWY----RATHQEAINCYAE----ETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYIL-LNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL-----
83emlA 0.17 0.25 0.91 2.85Download --VLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGEGQVACLFEDV--------VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQ-----LVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKII-------
93emlA 0.19 0.25 0.95 7.35Download IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYGLVTGTRAKGIIAICWVLSFAIGLT--------PMLGWNNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFC----PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR-SHVLR
103emlA 0.18 0.25 0.94 3.44Download IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFE-----------DVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFC----PDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL-R
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on Q9H2C7_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. GPCR-I-TASSER: A new hybrid approach to G protein-coupled receptor structure modeling with application to the human genome, submitted, 2014.