GPCR-I-TASSER results for Q7Z5H4

[Click on Q7Z5H4_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q7Z5H4
MLKLVIIENMAEIMLFSLDLLLFSTDILCFNFPSKMIKLPGFITIQIFFYPQASFGISAN
TILLLFHIFTFVFSHRSKSIDMIISHLSLIHILLLFTQAILVSLDFFGSQNTQDDLRYKV
IVFLNKVMRGLSICTPCLLSVLQAIISPSIFSLAKLKHPSASHILGFFLFSWVLNMFIGV
IFCCTLRLPPVKRGQSSVCHTALFLFAHELHPQETVFHTNDFEGCHLYRVHGPLKRLHGD
YFIQTIRGYLSAFTQPACPRVSPVKRASQAILLLVSFVFTYWVDFTFSFSGGVTWINDSL
LVWLQVIVANSYAAISPLMLIYADNQIFKTLQMLWFKYLSPPKLMLKFNRQCGSTKK

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MLKLVIIENMAEIMLFSLDLLLFSTDILCFNFPSKMIKLPGFITIQIFFYPQASFGISANTILLLFHIFTFVFSHRSKSIDMIISHLSLIHILLLFTQAILVSLDFFGSQNTQDDLRYKVIVFLNKVMRGLSICTPCLLSVLQAIISPSIFSLAKLKHPSASHILGFFLFSWVLNMFIGVIFCCTLRLPPVKRGQSSVCHTALFLFAHELHPQETVFHTNDFEGCHLYRVHGPLKRLHGDYFIQTIRGYLSAFTQPACPRVSPVKRASQAILLLVSFVFTYWVDFTFSFSGGVTWINDSLLVWLQVIVANSYAAISPLMLIYADNQIFKTLQMLWFKYLSPPKLMLKFNRQCGSTKK
PredictionCCSSSSSHHHHHHHHCCHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCSSSSSSHHHHCCCCHHHHHHHHHHCSSSCCCCCHHHHHHHHCCCSSHHHHHHHHHHHHHHHHHCSSSSSSCCCCCCCSSSSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHCHCHHHCHHHSSCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCC
Conf.Score914874111367861068998428136666523433345789999999999999999899999999999998387999599999999999999999976999999973430589886159998726645310657888886216881898217778772677347699999999998751305899935654440337998851288999998899988999999999999975613154321110000024467889999878989879898999999997529996899985479943201999995013252733332079762189999828778880786876301577789

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
MLKLVIIENMAEIMLFSLDLLLFSTDILCFNFPSKMIKLPGFITIQIFFYPQASFGISANTILLLFHIFTFVFSHRSKSIDMIISHLSLIHILLLFTQAILVSLDFFGSQNTQDDLRYKVIVFLNKVMRGLSICTPCLLSVLQAIISPSIFSLAKLKHPSASHILGFFLFSWVLNMFIGVIFCCTLRLPPVKRGQSSVCHTALFLFAHELHPQETVFHTNDFEGCHLYRVHGPLKRLHGDYFIQTIRGYLSAFTQPACPRVSPVKRASQAILLLVSFVFTYWVDFTFSFSGGVTWINDSLLVWLQVIVANSYAAISPLMLIYADNQIFKTLQMLWFKYLSPPKLMLKFNRQCGSTKK
Prediction602000033023000000101010131010213342321122000101022113333333320032100000243331110000100131011102011211000000221013331000000000001010000000000100000032120230122012000000010021000000200010203323323210110000000100110111110100000001101200100100211333333333344632443321320000000000001001210000000111334210000000020131010000000001420120020003253421300230354244468
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=-1.83
 C-score=-3.03
 C-score=-2.18
 C-score=-3.19
 C-score=-4.31
 
Estimated accuracy of Model1: 0.49±0.15 (TM-score)    10.8±4.6Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.
Download estimated local accuracy of Model2, Model3, Model4, Model5

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
Sec.Str
Seq		CCSSSSSHHHHHHHHCCHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCSSSSSSHHHHCCCCHHHHHHHHHHCSSSCCCCCHHHHHHHHCCCSSHHHHHHHHHHHHHHHHHCSSSSSSCCCCCCCSSSSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCHHHHHHHCHCHHHCHHHSSCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCC
MLKLVIIENMAEIMLFSLDLLLFSTDILCFNFPSKMIKLPGFITIQIFFYPQASFGISANTILLLFHIFTFVFSHRSKSIDMIISHLSLIHILLLFTQAILVSLDFFGSQNTQDDLRYKVIVFLNKVMRGLSICTPCLLSVLQAIISPSIFSLAKLKHPSASHILGFFLFSWVLNMFIGVIFCCTLRLPPVKRGQSSVCHTALFLFAHELHPQETVFHTNDFEGCHLYRVHGPLKRLHGDYFIQTIRGYLSAFTQPACPRVSPVKRASQAILLLVSFVFTYWVDFTFSFSGGVTWINDSLLVWLQVIVANSYAAISPLMLIYADNQIFKTLQMLWFKYLSPPKLMLKFNRQCGSTKK
12z73A 0.10 0.17 0.91 1.28Download ------------ETWWYNPSIVVHPHWREFDQVPD----AVYYSLGIFIGICGIIGCGGNGIVIYLFTKT---KSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWFGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMA--ASKKMSHRRAFIMIIFVWLWSVLWAIG--------PIFGWGAYTLEGVLCNCSFDYINILCMFILGFGPILIIFFCYFNIVM-SVSNHEKEMAAMAKRLNAKELAGANAEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAISQTWVLTCCQFEDDKDAETEIPAGE-
23vw7A 0.15 0.17 0.79 2.93Download ------------------------------DASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFI---LKMKVKKPAVVYMLHLATADVLFVSV--LPFKISYFGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIFLAVVYPM---------RTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLGITTCHDVAFSAVFFFVPLIISTVCYVSIIRCLSSSANIFEMLRIDEGLRNVRGIVAGLNQPAYANRSKKSRALFLSAAVFCFIICFGPTNVLLIAHYSFLEAAYFAYLLCVCVSSISCCIDPLIYYYASSEC------------------------------
34grvA 0.11 0.14 0.78 1.12Download -----------------------------NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLA-----RKSLQTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHAFGDAGCRGYYFLRDACTYATALNVASLSVARYLAHPFKAK----TLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTH-PGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMSGSVQ-----------ALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQWFYMLTNALAYASSAINPILYNLVSANFRQV---------------------------
42z73A 0.13 0.17 0.91 2.00Download -----------ETWWYNPSIV-VHPHWREFDQVPD----AVYYSLGIFIGICGIIGCGGNGIVIYLFTK---TKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISCFLKKWFGFAACKVYGFIGGIFGFMSIMTMAMISIDRVIGRPMAAS----KKMSHRRAFIMIIFVWLWSVLWAIGPIFYTCSFDYISRDSTTRSNILCMFILGFGPILIIFFCYFNIVMSVSNHEKEMAAMAKRLNAKELRKAQAGAN--------AEMRLAKISIVIVSQFLLSWSPYAVVALLAQFGPLTPYAAQLPVMFAKASAIHNPMIYSVSHPKISQTFPWVLTCCQFDDKETEDDKDAETEIPA
51xm9A 0.10 0.15 0.96 1.63Download GLT---IPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVGICKLVVQQAAAGALRNLVLETRREAVSLLRRTGNAEIQKQLTGLLWNLSELIADALPVLADRVIIPFSGWCVVDPEVFFGRQTMRNYSGLIDSLMAYVQ--------NCVAASRCDDKSVENCMCVLHNLRLDAEVPTRYRQLEYNALPEEETNPKGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKLQSGNSDVVGASLLSNMSPLLHRVMGNQVFPEVTRLLTSHTGNTSNSEDILSSACYTV--RNLMASQPQLAKQYIINLCRSSASPKAAEAARLKELQGVL
64grvA 0.13 0.14 0.75 1.59Download ------------------------------------------VLVTAIYLALFVVGTVGNSVT----LFTLARKSLQSTVHYHLGSLALSDLLILLL-AMPVELYNFIWVHAFGDAGCRGYYFLRDACTYATALNVASLSVYLAICHPFKAK----TLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMSGSVQA------------LRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEQYFYMLTNALAYASSAINPILYNLVSANFRQV---------------------------
72rh1A 0.09 0.20 0.82 3.37Download -------------------------------------DEVWVVGMGIVMSLIVLAIVFGNVLVITA---IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQS--LLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCD--FFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL--------------------
82ks9A 0.11 0.20 0.77 1.73Download ----------------VDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH---KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFYMAIIHPLQPR------LSATATKVVICVIWVLALLLAFPQGYYSTTET--MPSRVVCMIEWVTVLIYFLPLLVIGYAYTVVGITLWASEIPGD--SS---------------DRYHEQVSAKRKVVKMMIVVVCFAICWLPFHIFFLLPYINPDLYLKKFQQIMWLAMSSTMYNPII--------------------------------------
94djhA 0.11 0.15 0.77 1.28Download -------------------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRY---TKMKTATNIYIFNLALADALVTTTMPFQSTVYLMN-SWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRAVCHPVKALDFRTPLKA----KIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFYSWWDLFMKICVFIFAVIPVLIIIVCYTLMILRLKSVRLLSDR----------------NLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFP--------------------
104grvA 0.10 0.14 0.78 1.49Download --------------------------------LDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLAR----KSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHAFGDAGCRGYYFLRDACTYATALNVASLSVARYLCHPFKAK----TLMSRSRTKKFISAIWLASALLAIPMLTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPMLVISILNTVIANKLTVMS-------------GSVQALRHGVLVARAVVIAFVVCWLPYHVRRLMFCYISDEHYFYMLTNALAYASSAINPILYNLVSANFRQV---------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on Q7Z5H4_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted, 2015.