GPCR-I-TASSER results for Q6XGY1

[Click on Q6XGY1_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q6XGY1
MSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLG
SRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHAGPDPFTQCVTKGSFKAQWQETTYNLFTF
CCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLALL
ILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCR
RGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |           
MSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHAGPDPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI
PredictionCSSSSSHHHHHHHHHHCCSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHSSSSSCCCCSSSSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score989852379999999382508358987999999999999999999999987999746083837477850249999999999999983799827998489997699841689999999999999999999999999999999977245777766655533321021788888799999999999999998999999999997765476458999999999999999998999996298999999998567777887766667777777677278688888888688614889

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |           
MSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHAGPDPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI
Prediction400230330200000141200120021013001010000200010011022013213142133201000000000001002111011003324643211000113123411221120000001232430220011032002223433446444455444444444433323210000000010010113141320101200241223413312222022233432232222100016411400230021134444644355444434434444444444444444343447
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=1.13
C-score=-1.32
C-score=-4.70
C-score=-5
C-score=-3.59
 
Estimated accuracy of Model1: 0.87±0.07 (TM-score)    3.8±2.6Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.
Download estimated local accuracy of Model2, Model3, Model4, Model5

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit
Iden1Iden2Cov.Norm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |           
Sec.Str
Seq
CSSSSSHHHHHHHHHHCCSCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHSSSSSCCCCSSSSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSAGNGTPWDATWNITVQWLAVDIACRTLMFLKLMATYSAAFLPVVIGLDRQAAVLNPLGSRSGVRKLLGAAWGLSFLLAFPQLFLFHTVHAGPDPFTQCVTKGSFKAQWQETTYNLFTFCCLFLLPLTAMAICYSRIVLSVSRPQTRKGSHAPAGEFALPRSFDNCPRVRLRALRLALLILLTFILCWTPYYLLGMWYWFSPTMLTEVPPSLSHILFLLGLLNAPLDPLLYGAFTLGCRRGHQELSIDSSKEGSGRMLQEEIHAFRQLEVQKTVTSRRAGETKGISITSI
12ks9A 0.16 0.20 0.96 3.06Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQSATATKVVICVIWVLALLLAFPQGYYSTTETMP--SRVVCMIEWPEHPNIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSS---------DRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPF--ISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVV
22rh1A 0.19 0.18 0.84 2.94Download VMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSKARVIILMVWIVSGLTSFLPIQHWYRATH--QEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIRIDERNTGETGGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN---LIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL------------------------------------------
32ks9A 0.17 0.20 0.97 3.06Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH---------EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA
42ks9A 0.17 0.20 0.97 3.82Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH---------EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA
52ks9A 0.17 0.20 0.97 3.69Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMI-EWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH---------EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA
62ks9A 0.18 0.20 0.96 4.68Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQSATATKVVICVIWVLALLLAFPQGYYSTTETM-PSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQ---------VSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVG-
72rh1A 0.18 0.18 0.84 3.36Download VMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSKARVIILMVWIVSGLTSFLPIQMHWYRATHQ-EAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNIFEMLRIDTGETGTWDAYKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDN---LIRKEVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL------------------------------------------
82ks9A 0.17 0.20 0.92 7.30Download -MAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRTATKVVICVIWVLALLLAFPQGYYSTTETM--PSRVVCMIEWP--EHIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV---------SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLSTRYLQTQGSVYKVSRLETTIS--------
92ks9A 0.17 0.20 0.97 3.86Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV-CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH---------EQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGA
102ks9A 0.16 0.20 0.96 3.75Download SMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQSATATKVVICVIWVLALLLAFPQGYYSTTETMPS-RVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDS---------SDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPF---ISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTV
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on Q6XGY1_results.tar.bz2 to download the tarball file including all modeling results listed on this page]



 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. GPCR-I-TASSER: A new hybrid approach to G protein-coupled receptor structure modeling with application to the human genome, submitted, 2014.