GPCR-I-TASSER results for Q6IEX5

[Click on Q6IEX5_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>tr|Q6IEX5|Q6IEX5_HUMAN
MRWIFFVLFLLFYIVIMVGNLLIFLMVFSDPQLHTPMYFFLSNLSFVDIAYSSATAPKMI
ADFVSEKKTISYWGCITQMFTFHFFGCAEIFVLTVMAFDRYAAICQPLRYTVIMSANACT
VLASLSWLGALGHSFVQTLLTFQLPFCNAQVIDHYFCDVHPVLKLACADTTLINMLVVAN
SGLISLGCFLILLASYKVILLSLQKQSAESRRKALSTCGSHLTVVTFFFVPCIFIYLRPS
TTFPLDKAVSVFYTTITPMLNPLIYTLRNEDVKNAMRQLWSSKISLKEKQRG

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |            
MRWIFFVLFLLFYIVIMVGNLLIFLMVFSDPQLHTPMYFFLSNLSFVDIAYSSATAPKMIADFVSEKKTISYWGCITQMFTFHFFGCAEIFVLTVMAFDRYAAICQPLRYTVIMSANACTVLASLSWLGALGHSFVQTLLTFQLPFCNAQVIDHYFCDVHPVLKLACADTTLINMLVVANSGLISLGCFLILLASYKVILLSLQKQSAESRRKALSTCGSHLTVVTFFFVPCIFIYLRPSTTFPLDKAVSVFYTTITPMLNPLIYTLRNEDVKNAMRQLWSSKISLKEKQRG
PredictionCCCHHHHHHHHHHHHHHHHHHHHSSSSSCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCSSCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHCHHHHHHHHHHHHHHHHHHHHCCSSSSSCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHCCCC
Conf.Score9402999999999999997887344133079999978999886998756354347199999973599778689999999999999999999999999760888563314612268759999999999999999999999951389989883767641808989885013146676688786699999899999999999999732175032399989988999163662064568858899984056678998625540003754246099999999999830782120079

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |            
MRWIFFVLFLLFYIVIMVGNLLIFLMVFSDPQLHTPMYFFLSNLSFVDIAYSSATAPKMIADFVSEKKTISYWGCITQMFTFHFFGCAEIFVLTVMAFDRYAAICQPLRYTVIMSANACTVLASLSWLGALGHSFVQTLLTFQLPFCNAQVIDHYFCDVHPVLKLACADTTLINMLVVANSGLISLGCFLILLASYKVILLSLQKQSAESRRKALSTCGSHLTVVTFFFVPCIFIYLRPSTTFPLDKAVSVFYTTITPMLNPLIYTLRNEDVKNAMRQLWSSKISLKEKQRG
Prediction4322002301331332333332002002003301000010022000100110000002000000164310104000000110011021003001100300000002101010000330000002201310130032013001303000313010000022100300011033202311330233033113203311220020012213612310000010020002013200100000033333200010131033203311300101042024002300433032454678
Values range from 0 (buried residue) to 9 (highly exposed residue)

  Top 5 Models predicted by GPCR-I-TASSER

Download Model 1 Download Model 2 Download Model 3 Download Model 4 Download Model 5
C-score=0.76
 C-score=-2.81
 C-score=-3.42
 C-score=-3.67
 C-score=-4.26
 
Estimated accuracy of Model1: 0.82±0.09 (TM-score)    4.6±3.0Å (RMSD)    (Read more about C-score of generated models)
Estimated local accuracy of Model1: The estiamted distances (between model and native structure, shown in 1st figure) for residues are more reliable for aligned (i.e., residues with high alignment coverage shown in 2nd figure) α-helix and β-strand regions.
Download estimated local accuracy of Model2, Model3, Model4, Model5

  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |            
Sec.Str
Seq		CCCHHHHHHHHHHHHHHHHHHHHSSSSSCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCSSCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHSSCCCCCCCCCCCSSCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHCHHHHHHHHHHHHHHHHHHHHCCSSSSSCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHCCCC
MRWIFFVLFLLFYIVIMVGNLLIFLMVFSDPQLHTPMYFFLSNLSFVDIAYSSATAPKMIADFVSEKKTISYWGCITQMFTFHFFGCAEIFVLTVMAFDRYAAICQPLRYTVIMSANACTVLASLSWLGALGHSFVQTLLTFQLPFCNAQVIDHYFCDVHPVLKLACADTTLINMLVVANSGLISLGCFLILLASYKVILLSLQKQSAESRRKALSTCGSHLTVVTFFFVPCIFIYLRPSTTFPLDKAVSVFYTTITPMLNPLIYTLRNEDVKNAMRQLWSSKISLKEKQRG
14iaqA 0.24 0.23 0.82 2.09Download WKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGR----WVVCDFWLSSDITCCTASIWHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISILYTVYSTVGAF---------------------------------------YFPTLLLIALYGRIYVEARSLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPIH-LAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFK---------
23uonA 0.16 0.19 0.92 2.69Download EVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV--GVRTVEDGECYIQFFS---------NAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRINSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPNVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLM-----------
33emlA 0.19 0.21 0.93 3.89Download GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS---GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVPMNYMVYFNF-----------FACVLVPLLLMLGVYLRIFLAARQLVHAAKSLAIIVGLFALCWLPLH-IINCFTFFCPDCAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ-----
41l9hA 0.16 0.20 0.97 4.58Download QFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFR-FGENHAIMGVAFTWVMALACAAPPLVG--WSRYIPEGMQCSCGIDYYT-----PHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAATTQKAEKEVTRMVIIMVIAFLICFYIFTHQGSDFPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGKNPLGDSTT
53emlA 0.20 0.21 0.93 4.46Download ISSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVPMNYMVYFNFFACV-----------LVPLLLMLGVYLRIFLAARQLVHAAKSLAIIVGLFALCWL-PLHIINCFTFFCPDCSHAWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVL-----RQ
63v2wA 0.18 0.21 0.84 2.00Download ISALTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATT--KLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKNNFRLFL--------LISACWVISLILG------------------------GLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSENVALLKTVIIVLSVFIACWAPLFILLL-KTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRI-------------
72rh1A 0.21 0.25 0.93 3.09Download WVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMWYR-----ATHQEAINCYAE----ETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLNLKEHKALKTLGIIMGTFTLCWLPFFIVNIVQDNLIREVYILLNWIGYVNSGFNPLIYC-RSPDFRIAFQELLCL----------
83emlA 0.19 0.21 0.90 3.09Download -SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIS--TGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQSQGCGEGQVACLFEDV--------VPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQ----LVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKI-------------
93emlA 0.20 0.21 0.94 9.92Download GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLNCGQSQGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ-----
103emlA 0.20 0.21 0.94 4.29Download GSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGGCGEGQVACLFEDVVP-----------MNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ-----
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: SPARKS-X   2: HHSEARCH2   3: MUSTER   4: SP3   5: PROSPECT2   6: FFAS03   7: HHSEARCH   8: PRC   9: dPPAS   10: Neff-PPAS   


[Click on Q6IEX5_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


 Please cite following article when you use the GPCR-I-TASSER server:
J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted, 2015.