Detailed GPCR-I-TASSER Statistics for Q86SQ3

Submitted Sequence

>sp|Q86SQ3|AGRE4_HUMAN
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECET
GLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWV
SGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLV
ALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLF
LTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRF
MYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVL
WILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSF
TIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN

Predicted Secondary Structure

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                 
Sequence MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
Prediction CCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCHHHHSSSSSHHHHHHHHHSSSSSSSCCCCCCCCSSSCCCCCSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSCCHHHHHHHHHHCCCCCCCC
Conf.Score 9856999766899899999999388997433887673777873314999986640342479999999973122477377882687715897555677566654577755443446886433445443333345554433443333222223344432234444334434343355543234466544300000011256888999999999987514311443058999999999888632441124555430137889999999999999999999987310210234444531234167643243332233137999526677754586688746899963389999998999999999998764321123462999999999999999999999986054400377609999999999999999988402244508999999999803787899

Predicted Solvent Accessibility

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
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Sequence MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
Prediction 7312000001142413311620514111202033103243233303323330430340334344134313033232001010233332344443334333241233313123324243233222232333244433332000002134230133203233344220202321000000000134444200200010000000000110010000002243320100000000002111000000213313000000000001000000000000020002001101212323342000000000001100000000000226212210000024200000000110000110321121000000231343446344243002000000000000230100000001334320100000000000030001000000011540041013103426578

Predicted Normalized B-Factor


Read more about predicted normalized B-factor

  Top 10 Templates Used by GPCR-I-TASSER


Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440
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Sec.Str
Seq		CCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHSSSSCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCCHHHHSSSSSHHHHHHHHHSSSSSSSCCCCCCCCSSSCCCCCSSSSSSHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSCCHHHHHHHHHHCCCCCCCC
MGSRFLLVLLSGASCPPCPKYASCHNSTHCTCEDGFRARSGRTYFHDSSEKCEDINECETGLAKCKYKAYCRNKVGGYICSCLVKYTLFNFLAGIIDYDHPDCYENNSQGTTQSNVDIWVSGVKPGFGKQLPGDKRTKHICVYWEGSEGGWSTEGCSHVHSNGSYTKCKCFHLSSFAVLVALAPKEDPVLTVITQVGLTISLLCLFLAILTFLLCRPIQNTSTSLHLELSLCLFLAHLLFLTGINRTEPEVLCSIIAGLLHFLYLACFTWMLLEGLHLFLTVRNLKVANYTSTGRFKKRFMYPVGYGIPAVIIAVSAIVGPQNYGTFTCWLKLDKGFIWSFMGPVAVIILINLVFYFQVLWILRSKLSSLNKEVSTIQDTRVMTFKAISQLFILGCSWGLGFFMVEEVGKTIGSIIAYSFTIINTLQGVLLFVVHCLLNRQVRLIILSVISLVPKSN
14l6rA 0.17 0.20 0.83 1.69Download ------------------------------------------ADLEDNWETLNDNKVIEKADNA--KDALTKMRAAALDAQ------KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKL---------------------ANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLL-----GLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
24l6rA 0.19 0.20 0.67 2.84Download --------------------------------------------------------------------------------------------------------------------------------------------------NEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLAT-----LPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
34l6rA 0.16 0.20 0.82 2.91Download ----------------------------------------------------DNWETLNDNLKVIEKDALTKMRAAALDAQ-------------------------KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLG-----LATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRAR--QMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
45ee7A 0.23 0.14 0.54 2.36Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YSSFQVMYTVGYSLSLAALLLALAILGGLSKLHCTANAIHANLFLSFVLKASAVLFIDGLLRAVAACRVAAVFMQYGIVANYCWLLVEGLYLHNLLG----------LRSFFSLYLGIGWGAPALFVVPWAVVKCLFE-NVQCW--TNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRA--RQMHHTDYAFRLAKSTLTLIPLLGVHFVVFAFVTDEHRS----AKLFFDLALSSFQGLLVAVLYCFLNKEVQSELRRRWHRA----
54l6rA 0.16 0.20 0.80 2.20Download -----------------------------------------------------------------------------------ADLEEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQILKLANEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTLAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATL-----PERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD--YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGK
65vaiA 0.19 0.14 0.58 2.50Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSPEERLLSLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDATYQDSLGCRLVFLLMQYCVAANYYWLLVEGAYLYTLLAFAVF-----SEQRIFKLYLSIGWGVPLLFVIPWGIVKY-LYEDEGCWTRNSNNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDI--KCRLAKSTLTLIPLLGTHEVIFAFVMDEHRGTLRFVKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKSWERWR---
75nx2A 0.17 0.19 0.81 1.33Download ------------------------------------------------------------TVSLWET----VQKWREYRRQCQRSLTEDPPPATDLF---CNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTA--------EGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSCRLVFLFMQYCVAANYYWLLVEGVYLYTLL-----AFSVFSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEACWARNSNMNYWLIIRLPILFAIGVNFLIFVRVIAIVVSKLK--ANLMCKTDIKCRLAKSTLTLIALLATVEVIFAFVMDEHAGTLRFIKLFTELSFTSFQGLMVAILYCFANNEVQLEFRKSW-------
85vaiA 0.19 0.14 0.58 2.14Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSPEERLLSLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDATYQDSLGCRLVFLLMQYCVAANYYWLLVEGAYLYTLLAFAVF-----SEQRIFKLYLSIGWGVPLLFVIPWGIVKY-LYEDEGCWTRNSMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDI--KCRLAKSTLTLIPLLGTHEVFAFVMDEHARGTLRFVKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKSWERWR---
95l7dA 0.10 0.17 0.88 2.33Download -----------PPPLSHCGRAAPCLRYNVCLG----SVLPYGATSTLLAGDSDSQEECENDRVELPSRTLCQATRGP----CAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSS--------------------------------GQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLGEPTSNETLSCVIIFVIVYYALMAGFVWFVVLTYAWHTSFKALQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDG----DSVSGICFVGYKNYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSARRQLADLEDNWETLNDNLKVIEKAQVKDALTKMRAAALDAQKATPPSPEMKDFRHGFDILVGQIDDALKLANERSFRDYVLCQANVTIGLP
104k5yA 0.25 0.15 0.53 2.97Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDA-----YDRLRAWMFICIGWGVPFPIIVAWAIG-KLYYDNEKCWAGKRPGVYYIYQGPMALVLLINFIFLFNIVRILMTKLRAST--TSETIQARKAVKATLVLLPLLGITYMLAFVN-----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: Neff-PPAS   4: SPARKS-X   5: wdPPAS   6: HHSEARCH2   7: cdPPAS   8: HHSEARCH I   9: PROSPECT2   10: HHSEARCH   

  Top 5 Models Predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-2.53 (Read more about C-score)
  • Estimated TM-score = 0.42±0.14
  • Estimated RMSD = 13.3±4.1Å

  • Download Model 2
  • C-score = -3.00

  • Download Model 3
  • C-score = -3.31

  • Download Model 4
  • C-score = -2.90

  • Download Model 5
  • C-score = -3.71


    • [Click on Q86SQ3_results.tar.bz2 to download the tarball file including all modeling results listed on this page]