[Home] [Server]

GPCR-I-TASSER results for job id O00254

[Click on O00254_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>O00254
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWT
GATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLF
FRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCS
ILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQP
DITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYV
KASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFL
MSKTRNHSTAYLTK

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |              
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
PredictionCCCHHHHHCCHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCHHHHHHHHHHCC
Conf.Score90048735120410543358888830103578999875667899987677997445676677777788898788886788986445664216885189999999999999999988986631677789999999999999999968999999847998988866799999999999999999999999984687640020244777402556779999999999989999722156068985799603897440179999999999999999999999999999999970577768738999999999999997899999999998741451479999999999999999988679674248418899997049

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |              
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
Prediction32000100011000010003343454454344442314114344443234122432443434423373423434344242444134324440210000210120023033232100000001333210000000000021000000001000003443111020000000011121010000000000100010000002023223221000000001100110110100012034277432010002134743322010001121112012201200220000001102346542100000000001000001231010000200231052240020011001000020002000000000440141033027
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |              
Sec.Str
Seq		CCCHHHHHCCHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCSSSSSSCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHSSCHHHHHHHHHHCC
MKALIFAAAGLLLLLPTFCQSGMENDTNNLAKPTLPIKTFRGAPPNSFEEFPFSALEGWTGATITVKIKCPEESASHLHVKNATMGYLTSSLSTKLIPAIYLLVFVVGVPANAVTLWMLFFRTRSICTTVFYTNLAIADFLFCVTLPFKIAYHLNGNNWVFGEVLCRATTVIFYGNMYCSILLLACISINRYLAIVHPFTYRGLPKHTYALVTCGLVWATVFLYMLPFFILKQEYYLVQPDITTCHDVHNTCESSSPFQLYYFISLAFFGFLIPFVLIIYCYAAIIRTLNAYDHRWLWYVKASLLILVIFTICFAPSNIILIIHHANYYYNNTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKTRNHSTAYLTK
15unfA 0.22 0.26 0.97 3.30Download LKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRH-GFDILVGQIDDAL----KLANEGKVKEAQAAAEQLKTTRNAHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFPWQ-------ASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFP-PEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
25vblA 0.27 0.23 0.76 4.06Download ----------------------------------------------------------------------------------------DWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSRRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASAFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTNKVQCYMDYSMVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAMKKEERRRLLSIIVVLVVTFALCKMPYHLVKTLYMLGSPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLL
35unfA 0.21 0.26 0.97 3.73Download LKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEG-----KVKEAQAAAEQLKTTRNAHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFP-------WQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPP-EKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
45nddA 0.36 0.31 0.79 3.85Download ---------------------------------------------------------------------------EFFSVDEFSASVLTGKLTTVFLPIVYTIVFVVALPSNGMALWVFLFRTKKAPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYANMYCSILFLTCLSVQRAWEIVNPMGHSR-KKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALQITTCHDVLP-EQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRAL-NSEKKRKRAIKLAVTVAAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNAL-
55unfA 0.22 0.26 0.97 3.68Download LKVIEKADNAAQVKDALTKMRAAALDAQKATPPKL-----EDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFPW-------QASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPP-EKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSTRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
64djh 0.26 0.23 0.74 1.54Download -----------------------------------------------------------------------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRTKMKTATNIYIFNLALADALVTTTMPFQSTVYL-MNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDD-YSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSA------ALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCF
74rwaA 0.21 0.27 0.98 4.34Download NAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQTTRNAYIQKYLGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYKMKTATNIYIFNLALADALATSTLPFQSAKYLM-ETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRD--GAVVCMLQFPSP--SWYWDTVTKICVFLFAFVVPILIITVCYGLMLLGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLC-
84djh 0.27 0.23 0.74 1.18Download -----------------------------------------------------------------------------------------SPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTMKTATNIYIFNLALADALVTTTMPFQSTVYLM-NSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDD-YSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSA------ALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCF
95unfA 0.21 0.26 0.98 4.38Download ADLEDNWETLNDNLKVIEKADNAAQRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAHLDAIPILYYIIFVIGFLVNIVVVTLFCCKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFPW-------QASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFP-PEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVIIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
104djh 0.27 0.23 0.73 1.72Download --------------------------------------------------------------------------------------------IPVIITAVYSVVFVVGLVGNSLVMFVIIRYKMKTATNIYIFNLALADALVTTTMPFQSTVYL-MNSWPFGDVLCKIVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDD-DYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSA------ALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFC-
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: MUSTER   2: FFAS-3D   3: Neff-PPAS   4: SPARKS-X   5: wdPPAS   6: HHSEARCH2   7: cdPPAS   8: HHSEARCH I   9: PROSPECT2   10: HHSEARCH   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=0.23 (Read more about C-score)
  • Estimated TM-score = 0.74±0.11
  • Estimated RMSD = 6.2±3.8Å

  • Download Model 2
  • C-score = -1.62

  • Download Model 3
  • C-score = -0.22

  • Download Model 4
  • C-score = -1.42

  • Download Model 5
  • C-score = -3.46



    • [Click on O00254_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


     Please cite the following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. GPCR-I-TASSER: A hybrid approach to G protein-coupled receptor structure modeling and the application to the human genome, Structure, 23: 1538-1549, 2015.