GLASS 2.0

GLASS 2.0 is a significantly extended database of experimentally validated GPCR–ligand interactions. It is constructed using a hybrid approach that integrates curated entries from major public repositories—including BindingDB, ChEMBL, DrugBank, IUPHAR, and PDSP—with large language model (LLM)-powered text mining of primary literature. Compared to its predecessor (GLASS 1.0), GLASS 2.0 features a 92% increase in data volume, along with rigorous deduplication and normalization of experimental values, units, and identifiers. The database also offers optimized classification and regression datasets tailored for AI research, as well as newly resolved protein structures and computationally generated ligand conformations. (>> more about GLASS 2.0)

Find your GPCR interaction

Explore GPCR-ligand interactions with brand new GLASS 2.0

View illustrative examples of: DRD2_HUMAN, Dopamine, DRD2_HUMAN with Dopamine

Update History

NEW! January 26, 2026
Routine data update: full recompilation of the GLASS2 database.
Added gpcr_class field to protein.json. Introduced GPCR Class filtering in the protein browse (search) table, and displayed the GPCR Class in the protein information card on the GPCR details page.
January 16, 2026
Optimized the display logic of protein structures; added a custom classification dataset feature on the download page.
June 28, 2025
The brand-new GLASS 2.0 website was officially launched, featuring updated datasets, a redesigned user interface, and specially curated classification and regression datasets for AI study!
June 21, 2025 🎉GLASS 2.0!
Recompile and update GLASS database, incorporating LLM-based text mining, resulting in a 53% increase in data volume.
July 13, 2018
Add TSV files for interaction data filtered (by Kd, Ki, IC50, EC50) for active and inactive compounds in 'Download' section.
July 12, 2018
Replaced JMol viewer with NGL viewer. All GPCR structures are now loaded directly from GPCR-EXP, a new database we developed for experimentally-solved and predicted GPCR structures.
November 2, 2017
Fixed bug in update script that missed BioLiP entries from 2015 and onwards.
October 4, 2017
Fixed bug where searching with a ligand name as a query could result in an internal server error. Also fixed problem where synonym lists would not expand when clicked.
February 14, 2017
Happy Valentine's Day! The browse ligand and browse family features have been fixed. Thank you to Hongjiu Zhang for assistance.
August 5, 2016
Added 2D molecule structures to GPCR search results. Thank you to Dr. Andrew Horti for this useful suggestion. This change should hopefully facilitate the browsing of molecules.
June 24, 2016
Fixed bug where DrugBank entries were not showing up.
March 1, 2015
Redesigned the database schemas.
February 17, 2015
Migrated the website to the new framework.
August 12, 2014
Added searches for GPCR by family and for ligands by chemical structure.
June 30, 2014
Added batch TSV and SDF download.
June 28, 2014
Added synonyms for GPCRs and ligands, as well as Lipinski's rule of five check.
June 24, 2014
Set up the database website.

Internal Resources

D-I-TASSER: Deep learning-based Iterative Threading ASSEmbly Refinement. GPCR-EXP: A semi-manually curated database for experimentally-solved and predicted GPCR structures. GPCR-I-TASSER: A computational method designed for 3D structure prediction of G protein-coupled receptors. UniBioMap: Comprehensive Protein & Compound Centered Biomedical Knowledge Graph. GLASS 1.0: GPCR-ligand Association Database.

Browse the Database

Explore our complete collection of GPCRs, ligands, and families

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