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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesMus musculus (Mouse)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProtP30557
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4336
IUPHAR342
DrugBankN/A

Ligand

NameCHEMBL183933
Molecular formulaC23H25NO4
IUPAC name2-[1-(4-butoxybenzoyl)-2,5-dimethylindol-3-yl]acetic acid
Molecular weight379.456
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.3
SynonymsBDBM50150975
SCHEMBL12923737
[1-(4-Butoxy-benzoyl)-2,5-dimethyl-1H-indol-3-yl]-acetic acid
Inchi KeyGKSICVCQOHLSNK-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H25NO4/c1-4-5-12-28-18-9-7-17(8-10-18)23(27)24-16(3)19(14-22(25)26)20-13-15(2)6-11-21(20)24/h6-11,13H,4-5,12,14H2,1-3H3,(H,25,26)
PubChem CID11314979
ChEMBLCHEMBL183933
IUPHARN/A
BindingDB50150975
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID15357992BindingDB,ChEMBL

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