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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H3 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	Q9QYN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4124
IUPHAR	264
DrugBank	N/A

Ligand

Name	Carcinine
Molecular formula	C8H14N4O
IUPAC name	3-amino-N-[2-(1H-imidazol-5-yl)ethyl]propanamide
Molecular weight	182.227
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	-1.5
Synonyms	3-amino-N-[2-(1H-imidazol-5-yl)ethyl]propanamide ANW-66135 CCG-204305 HJD MLS002153803 NCGC00015221-03 SCHEMBL2819350 AC1L1DZE beta-Alanylhistamine HMS2235I06 N-[2-(1H-imidazol-4-yl)ethyl]-beta-alaninamide Prestwick2_000422 SPBio_002343 AKOS006271690 D06ZBV Lopac-C-2321 NCGC00015221-01 RT-003724 ZINC29747055 4CH-021715 AX8223359 CHEBI:131429 HMS1569E06 N-(2-(1H-Imidazol-5-yl)ethyl)-3-aminopropanamide Prestwick0_000422 SMP2_000161 AC1Q5P6Q BPBio1_000446 CHEMBL461024 HMS3371N06 N-[2-(1H-imidazol-5-yl)ethyl]-beta-alaninamide Prestwick3_000422 UNII-WIV0W167TC AKOS013465881 CAS-56897-53-1 DTXSID90205421 Lopac0_000210 NCGC00015221-02 SCHEMBL19051459 56897-53-1 beta-alaninylhistamine CHEBI:95262 HMS2096E06 N-beta-alanylhistamine Prestwick1_000422 SMR001233178 AK-84422 BSPBio_000404 CTK8C1268 KSC921E6R n-[2-(1h-imidazol-5-yl)ethyl]-\|A-alaninamide Propanamide, 3-amino-N-(2-(1H-imidazol-4-yl)ethyl)- WIV0W167TC [ Show all ]
Inchi Key	ANRUJJLGVODXIK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H14N4O/c9-3-1-8(13)11-4-2-7-5-10-6-12-7/h5-6H,1-4,9H2,(H,10,12)(H,11,13)
PubChem CID	2574
ChEMBL	CHEMBL461024
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	294.0 nM	PMID18683917	ChEMBL

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