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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 14
Species	Mus musculus (Mouse)
Gene	P2ry14
Synonym	G protein-coupled receptor 105 G-protein coupled receptor 105 GPR105 G protein coupled receptor for UDP-glucose P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y UDP-glucose receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	338
Amino acid sequence	MNNSTTTDPPNQPCSWNTLITKQIIPVLYGMVFITGLLLNGISGWIFFYVPSSKSFIIYLKNIVVADFLMGLTFPFKVLGDSGLGPWQVNVFVCRVSAVIFYVNMYVSIVFFGLISFDRYYKIVKPLLTSIVQSVNYSKLLSVLVWMLMLLLAVPNIILTNQGVKEVTKIQCMELKNELGRKWHKASNYIFVSIFWVVFLLLIVFYTAITRKIFKSHLKSRKNSTSVKRKSSRNIFSIVLVFVVCFVPYHIARIPYTKSQTEGHYSCRTKETLLYAKEFTLLLSAANVCLDPIIYFFLCQPFREVLNKKLHMSLKVQNDLEVSKTKRENAIHESTDTL
UniProt	Q9ESG6
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1770046
IUPHAR	330
DrugBank	N/A

Ligand

Name	CHEMBL1771230
Molecular formula	C26H23N5O
IUPAC name	4-(2-methylphenyl)-N-phenyl-2-pyridin-3-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxamide
Molecular weight	421.504
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.6
Synonyms	BDBM50343096 N-phenyl-2-(pyridin-3-yl)-4-o-tolyl-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxamide
Inchi Key	GIODXTFZELVTOA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H23N5O/c1-18-8-5-6-12-21(18)24-22-17-31(26(32)28-20-10-3-2-4-11-20)15-13-23(22)29-25(30-24)19-9-7-14-27-16-19/h2-12,14,16H,13,15,17H2,1H3,(H,28,32)
PubChem CID	54585441
ChEMBL	CHEMBL1771230
IUPHAR	N/A
BindingDB	50343096
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	4900.0 nM	PMID21507642	BindingDB,ChEMBL

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