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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Growth hormone-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Ghrhr
Synonym	Ghrfr GHRH receptor GRF receptor GRFR Growth hormone-releasing factor receptor
Disease	N/A for non-human GPCRs
Length	464
Amino acid sequence	MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProt	Q02644
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3709
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL540001
Molecular formula	C28H38ClN3O2
IUPAC name	2-amino-2-methyl-N-[(2R)-1-oxo-5-phenyl-1-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpentan-2-yl]propanamide;hydrochloride
Molecular weight	484.081
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	None
Synonyms	SCHEMBL8522552
Inchi Key	FZIWVQMHLNDEGI-GJFSDDNBSA-N
Inchi ID	InChI=1S/C28H37N3O2.ClH/c1-27(2,29)26(33)30-24(14-8-11-21-9-4-3-5-10-21)25(32)31-19-17-28(18-20-31)16-15-22-12-6-7-13-23(22)28;/h3-7,9-10,12-13,24H,8,11,14-20,29H2,1-2H3,(H,30,33);1H/t24-;/m1./s1
PubChem CID	45264075
ChEMBL	CHEMBL540001
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10.0 nM	Bioorg. Med. Chem. Lett., (1997) 7:17:2319	ChEMBL

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