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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Mus musculus (Mouse)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	335
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProt	Q7TQP3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2086689
Molecular formula	C20H19FN8O
IUPAC name	4-[[2-[(2R)-4-(5-fluoropyrimidin-2-yl)-2-methylpiperazin-1-yl]pyrimidin-5-yl]oxymethyl]pyridine-3-carbonitrile
Molecular weight	406.425
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	1.5
Synonyms	BDBM50420837 SCHEMBL1448043
Inchi Key	AMHHRGZLTPMKNL-CQSZACIVSA-N
Inchi ID	InChI=1S/C20H19FN8O/c1-14-12-28(19-24-8-17(21)9-25-19)4-5-29(14)20-26-10-18(11-27-20)30-13-15-2-3-23-7-16(15)6-22/h2-3,7-11,14H,4-5,12-13H2,1H3/t14-/m1/s1
PubChem CID	51030056
ChEMBL	CHEMBL2086689
IUPHAR	N/A
BindingDB	50420837
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	567.0 nM	PMID22545772	BindingDB,ChEMBL
Intrinsic activity	63.0 %	PMID22545772	ChEMBL

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