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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	Eticlopride
Molecular formula	C17H25ClN2O3
IUPAC name	5-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide
Molecular weight	340.848
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.1
Synonyms	3-Chloro-5-Ethyl-N-{[(2s)-1-Ethylpyrrolidin-2-Yl]methyl}-6-Hydroxy-2-Methoxybenzamide AC1L1MN4 CHEBI:92874 Eticlopride [INN] GTPL966 PDSP2_000909 (S)-3-chloro-5-ethyl-N-((1-ethylpyrrolidin-2-yl)methyl)-6-hydroxy-2-methoxybenzamide BRD-K50417881-003-02-6 D03KUH Eticlopridum NCGC00016963-01 SCHEMBL572121 3-Chloro-5-ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxy-benzamide (etichlopride) A 38503 C17H25ClN2O3 Eticloprida [Spanish] FLB 131 PDSP1_000923 5-chloro-3-ethyl-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide BDBM50007518 ETICLOPRIDE,S(-) J8M468HBH4 PDSP2_001501 3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxy-benzamide BRD-K50417881-003-05-9 DTXSID9048435 Eticlopridum [Latin] NCGC00161393-01 UNII-J8M468HBH4 3-Chloro-5-ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxy-benzamide(Eticlopride) AB00514697 CAS-97612-24-3 FLB-131 PDSP1_001517 (-)-(S)-5-Chloro-3-ethyl-N-((1-ethyl-2-pyrrolidinyl)methyl)-6-methoxysalicylamide 5-chloro-3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybenzamide BPBio1_000952 CHEMBL8946 Eticlopride;3-Chloro-5-ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxy-benzamide LS-26063 Prestwick3_000932 3-Chloro-5-ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxy-benzamide 97612-24-3 BSPBio_000864 Eticloprida ETQ NCGC00161393-02 ZINC1395 [ Show all ]
Inchi Key	AADCDMQTJNYOSS-LBPRGKRZSA-N
Inchi ID	InChI=1S/C17H25ClN2O3/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2/h9,12,21H,4-8,10H2,1-3H3,(H,19,22)/t12-/m0/s1
PubChem CID	57267
ChEMBL	CHEMBL8946
IUPHAR	966
BindingDB	50007518
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Change	-18.0 %	PMID12723940	ChEMBL
Change	-14.0 %	PMID12723940	ChEMBL
Change	24.0 %	PMID12723940	ChEMBL
IC50	0.92 nM	PMID1969484	BindingDB
IC50	0.92 nM	PMID7901417, PMID1969484, PMID1672158	BindingDB,ChEMBL
Kd	0.17 nM	PMID2966245, PMID2136916	BindingDB,ChEMBL
Ki	0.02 nM	PMID8301592	BindingDB
Ki	0.04 nM	PMID2531826	BindingDB
Ki	0.06 nM	PMID8301592	BindingDB
Ki	0.07 nM	PMID10327430	BindingDB
Ki	0.09 nM	PMID8093734	BindingDB,ChEMBL
Ki	0.12 nM	PMID1969484	BindingDB,ChEMBL
Ki	0.19 nM	PMID1827843	BindingDB,ChEMBL
Ki	0.22 nM	PMID10327430	BindingDB
Ki	0.31 nM	PMID2869639	BindingDB
Ki	0.79 nM	PMID10327430	BindingDB
Ki	0.92 nM	PMID2869639	BindingDB
Ki	0.99 nM	PMID1827843	ChEMBL
Ki	0.99 nM	PMID1827843	BindingDB
Ki	1.6 nM	PMID2869639	BindingDB

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