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GPCR

Name	Histamine H2 receptor
Species	Homo sapiens (Human)
Gene	HRH2
Synonym	HH2R H2R Gastric receptor I H2 receptor
Disease	Ulcerative colitis Pain Peptic ulcer Gastroesophageal reflux disease Gastric ulcer Gastric secretory disorders Stomach ulcer Duodenal ulcers Acid-reflux disorders [ Show all ]
Length	359
Amino acid sequence	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
UniProt	P25021
Protein Data Bank	N/A
GPCR-HGmod model	P25021
3D structure model	This predicted structure model is from GPCR-EXP P25021.
BioLiP	N/A
Therapeutic Target Database	T30985
ChEMBL	CHEMBL1941
IUPHAR	263
DrugBank	BE0000112

Ligand

Name	METIAMIDE
Molecular formula	C9H16N4S2
IUPAC name	1-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea
Molecular weight	244.375
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	0.5
Synonyms	AX8140020 FPBPLBWLMYGIQR-UHFFFAOYSA-N Methiamide Metiamidum N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl] thiourea N-Methyl-N'-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]thiourea SC-94342 1-Methyl-3-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]-2-thiourea UNII-3K7670861M BDBM81468 D05004 J-522704 MolPort-018-684-840 N-methyl-N'-[2-((5-methyl-4-imidazolyl)-methylthio)ethyl]thiourea NSC307755 SK&F 92058 3-methyl-1-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea ZINC5424950 ACM34839708 AKOS005065704 CAS_34839-70-8 DB08805 LS-160472 Metiamide [USAN:BAN:INN] N-methyl-N'-(2-{[(4-methyl-1H-imidazol-5-yl)methyl]sulfanyl}ethyl)thiourea N-methyl-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]thiourea PDSP2_000611 1-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea Thiourea, N-methyl-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)- 4243AB BCP21503 CHEMBL275446 GTPL1233 Metiamida Metiamidum [INN-Latin] N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-thiourea NSC 307755 SCHEMBL11363901 Urea, 1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)-2-thio- AE-641/30115027 C07449 D0W9LJ KB-219225 Metiamide (USAN/INN) N-Methyl-N'-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)thiourea N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]-thiourea NSC_1548992 1-Methyl-3-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)thiourea SK&F-92058 34839-70-8 API0007627 CHEBI:6896 DTXSID80188390 MCULE-4285442691 Metiamide [USAN:INN:BAN] N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)-ethyl]thiourea N-methyl-N'-[2-(5-methylimidazol-4-yl)methylthioethyl] thiourea RL03297 1-Methyl-3-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]thiourea;1-methyl-3-(2-((5-methyl-1H-imidazol-4-yl)methylthio)ethyl)thiourea Thiourea, N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- 4CA-0813 BDBM50000382 CS-1294 HY-15540 Metiamida [INN-Spanish] MolPort-002-801-395 N-methyl-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea NSC-307755 SCHEMBL534307 3-Methyl-1-(2-((5-methyl-4-imidazolyl)methylthio)ethyl)thiourea W-5324 AC1LU7MD AJ-54031 C9H16N4S2 L023988 Metiamide HCl N-Methyl-N'-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)thiourea # N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea PDSP1_000614 1-Methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)-2-thiourea SKF 92058 3K7670861M [ Show all ]
Inchi Key	FPBPLBWLMYGIQR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14)
PubChem CID	1548992
ChEMBL	CHEMBL275446
IUPHAR	1233
BindingDB	50000382, 81468
DrugBank	DB08805
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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