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Name | Prostaglandin E2 receptor EP4 subtype |
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Species | Homo sapiens (Human) |
Gene | PTGER4 |
Synonym | Prostanoid EP4 receptor PGE2 receptor EP4 subtype PGE receptor EP4 subtype EP4 receptor EP2 |
Disease | Ulcerative colitis Glaucoma Inflammatory disease Migraine Osteoarthritis [ Show all ] |
Length | 488 |
Amino acid sequence | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI |
UniProt | P35408 |
Protein Data Bank | 5ywy, 5yhl |
GPCR-HGmod model | P35408 |
3D structure model | This structure is from PDB ID 5ywy. |
BioLiP | BL0434347, BL0434289 |
Therapeutic Target Database | T18876 |
ChEMBL | CHEMBL1836 |
IUPHAR | 343 |
DrugBank | BE0003522 |
Name | CHEMBL3115074 |
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Molecular formula | C23H29ClN2O4 |
IUPAC name | 4-[(1S)-1-[[(2R)-1-(2-phenoxyethyl)piperidine-2-carbonyl]amino]ethyl]benzoic acid;hydrochloride |
Molecular weight | 432.945 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | None |
Synonyms | FMJSLPJYTAKVLJ-CQVJSGDESA-N SCHEMBL15401932 4-[(1S)-1-[[(2R)-1-(2-phenoxyethyl)piperidine-2-carbonyl]amino]ethyl]benzoic acid hydrochloride |
Inchi Key | FMJSLPJYTAKVLJ-CQVJSGDESA-N |
Inchi ID | InChI=1S/C23H28N2O4.ClH/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20;/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28);1H/t17-,21+;/m0./s1 |
PubChem CID | 72695026 |
ChEMBL | CHEMBL3115074 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5.62 nM | PMID26091726 | ChEMBL |
IC50 | 6.9 nM | PMID24900798 | ChEMBL |
IC50 | 68.8 nM | PMID26091726 | ChEMBL |
IC50 | 123.0 nM | PMID24900798 | ChEMBL |
IC50 | 126.0 nM | PMID26091726 | ChEMBL |
Ki | 40.6 nM | PMID26091726 | ChEMBL |
Ki | 54.0 nM | PMID24900798 | ChEMBL |
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