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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	1-Methylhistamine
Molecular formula	C6H11N3
IUPAC name	2-(1-methylimidazol-4-yl)ethanamine
Molecular weight	125.175
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	-0.6
Synonyms	AS-50436 CS-0054396 GTPL1241 Lopac-M-4910 N(tele)-methylhistamine NCGC00015677-02 PDSP1_000511 1-Methyl-4-histamine [2-(1-methyl-1H-imidazol-4-yl)ethyl]amine 2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine 5-25-09-00527 (Beilstein Handbook Reference) C05127 D0T6SC HY-W062542 MCULE-7688329107 N-Telle-methylhistamine NSC 66736 1-Methyl-1H-imidazole-4-ethanamine SCHEMBL196356 2-(1-Methyl-1H-imidazol-4-yl)ethylamine # AC1L1GBQ AF9B9F65-564B-4C50-B4AF-F195114242DE FT-0608087 KCB81T4EOF N(1)-methylhistamine N1-Methylhistamine NT-methylhistamine 1-methyl-4-(b-aminoethyl)imidazole UNII-KCB81T4EOF 1H-Imidazole-4-ethanamine, 1-methyl- (9CI) 4-(2-aminoethyl)-1-methyl-Imidazole BDBM50198912 CTK4J2221 GTPL1242 Lopac0_000757 N-tele methylhistamine NCGC00015677-03 PDSP2_000509 2-(1-methyl-1H-imidazol-4-yl)ethanamine 501-75-7 AC1Q3Z1K CCG-204842 DTXSID30198207 Imidazole, 4-(2-aminoethyl)-1-methyl- MolPort-006-803-985 N-[3H]methylhistamine NSC-66736 1-Methyl-4-(.beta.-aminoethyl)imidazole SCHEMBL3826532 1H-IMIDAZOLE, 4-(1-AMINOETHYL)-1-METHYL- 2-(1-methylimidazol-4-yl)ethanamine AKOS006350836 CHEMBL507 FT-0701318 L000842 N(sup 1)-Methylhistamine NCGC00015677-01 Ntau-Methylhistamine 1-Methyl-4-(beta-aminoethyl)imidazole ZINC403051 1H-Imidazole-4-ethanamine,1-methyl- 4-(2-Aminoethyl)-1-methylimidazole BRN 0110757 D0A4XL Histamine, 1-methyl- LS-78032 N-tele-Methylhistamine NCGC00162240-01 1,4-methylhistamine SB15504 2-(1-Methyl-1H-imidazol-4-yl)ethylamine AC1Q4VOV CHEBI:29009 FHQDWPCFSJMNCT-UHFFFAOYSA-N Imidazole, 4-(2-aminoethyl)-1-methyl- (8CI) N( 1)-Methylhistamine N.tau.-Methylhistamine NSC66736 1-Methyl-4-(2-aminoethyl)imidazole Tele-methylhistamine 1H-Imidazole-4-ethanamine, 1-methyl- 4-(1-aminoethyl)-1-methyl-1H-imidazole [ Show all ]
Inchi Key	FHQDWPCFSJMNCT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3
PubChem CID	3614
ChEMBL	CHEMBL507
IUPHAR	1242, 1241
BindingDB	50198912
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	>0.1 -	PMID1967317	ChEMBL

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