You can:
Name | Endothelin receptor type B |
---|---|
Species | Homo sapiens (Human) |
Gene | EDNRB |
Synonym | endothelin B receptor HSCR2 HSCR ETB receptor ET-BR [ Show all ] |
Disease | Arrhythmia Hypertension Pulmonary arterial hypertension Solid tumours Cancer [ Show all ] |
Length | 442 |
Amino acid sequence | MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS |
UniProt | P24530 |
Protein Data Bank | 6igl, 6igk, 5xpr, 5x93 |
GPCR-HGmod model | P24530 |
3D structure model | This structure is from PDB ID 6igl. |
BioLiP | BL0388813, BL0433639, BL0433638, BL0388896, BL0388814 |
Therapeutic Target Database | T92828 |
ChEMBL | CHEMBL1785 |
IUPHAR | 220 |
DrugBank | BE0000043 |
Name | CHEMBL56349 |
---|---|
Molecular formula | C26H21NO6 |
IUPAC name | 2-[4-(1,3-benzodioxol-5-yl)-1-[(2-methoxyphenyl)methyl]-2-oxoquinolin-3-yl]acetic acid |
Molecular weight | 443.455 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 3.4 |
Synonyms | [4-Benzo[1,3]dioxol-5-yl-1-(2-methoxy-benzyl)-2-oxo-1,2-dihydro-quinolin-3-yl]-acetic acid BDBM50289736 L016184 SCHEMBL6314927 |
Inchi Key | AKHRQANJSKGZGG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C26H21NO6/c1-31-21-9-5-2-6-17(21)14-27-20-8-4-3-7-18(20)25(19(26(27)30)13-24(28)29)16-10-11-22-23(12-16)33-15-32-22/h2-12H,13-15H2,1H3,(H,28,29) |
PubChem CID | 18936180 |
ChEMBL | CHEMBL56349 |
IUPHAR | N/A |
BindingDB | 50289736 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | , Bioorg. Med. Chem. Lett., (1997) 7:14:1883 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417