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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL327836
Molecular formula	C17H25N3
IUPAC name	3-[(3S)-1-[3-(dimethylamino)propyl]piperidin-3-yl]benzonitrile
Molecular weight	271.408
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	2.6
Synonyms	BDBM50039754 ZINC13738281 3-[(S)-1-(3-Dimethylamino-propyl)-piperidin-3-yl]-benzonitrile
Inchi Key	AKBLTSXPRUVMOS-QGZVFWFLSA-N
Inchi ID	InChI=1S/C17H25N3/c1-19(2)9-5-11-20-10-4-8-17(14-20)16-7-3-6-15(12-16)13-18/h3,6-7,12,17H,4-5,8-11,14H2,1-2H3/t17-/m1/s1
PubChem CID	10084584
ChEMBL	CHEMBL327836
IUPHAR	N/A
BindingDB	50039754
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<217.0 nM	PMID8064801	BindingDB,ChEMBL
Ki	2330.0 nM	PMID8064801	BindingDB,ChEMBL

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