You can:
Name | D(2) dopamine receptor |
---|---|
Species | Bos taurus (Bovine) |
Gene | DRD2 |
Synonym | Dopamine D2 receptor |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P20288 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3998 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL367343 |
---|---|
Molecular formula | C18H24N2O2 |
IUPAC name | 2-[(2S,4aR,10bR)-7,8-dihydroxy-4-propyl-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-2-yl]acetonitrile |
Molecular weight | 300.402 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.7 |
Synonyms | BDBM50017463 (7,8-Dihydroxy-4-propyl-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinolin-2-yl)-acetonitrile |
Inchi Key | AJWHXZISGINFJA-DAXOMENPSA-N |
Inchi ID | InChI=1S/C18H24N2O2/c1-2-9-20-11-12(7-8-19)10-15-13-4-6-17(21)18(22)14(13)3-5-16(15)20/h4,6,12,15-16,21-22H,2-3,5,7,9-11H2,1H3/t12-,15-,16-/m1/s1 |
PubChem CID | 14488754 |
ChEMBL | CHEMBL367343 |
IUPHAR | N/A |
BindingDB | 50017463 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1460.0 nM | PMID2565402 | BindingDB,ChEMBL |
Low | 100.0 % | PMID2565402 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417