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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Rattus norvegicus (Rat)
Gene	Chrm1
Synonym	cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS cholinergic receptor M1 muscarinic acetylcholine receptor M1 receptor M1R Chrm-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P08482
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL276
IUPHAR	13
DrugBank	N/A

Ligand

Name	tyramine
Molecular formula	C8H11NO
IUPAC name	4-(2-aminoethyl)phenol
Molecular weight	137.182
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.1
Synonyms	to_000085 KBio2_001693 4-hydroxy-Benzeneethanamine Tyramine, analytical standard L-Tyramine AB00051887-15 X8ZC7V0OX3 MFCD00149002 AKOS000156022 NCGC00016011-06 BBL027695 NCGC00016011-16 bmse000870 NSC-249188 p-Hydroxyphenylethylamine CAS-51-67-2 p-Hydroxy-.beta.-phenethylamine SCHEMBL4111 D01VFT .alpha.-(4-Hydroxyphenyl)-.beta.-aminoethane Spectrum5_000501 DZGWFCGJZKJUFP-UHFFFAOYSA-N Systogene HSDB 2132 4-(2-aminoethyl)-Phenol 4-13-00-01788 (Beilstein Handbook Reference) KBio3_001665 4-Hydroxyphenylethylamine Tyramine;4-(2-Amino-ethyl)-phenol LS-103895 AC1Q54AZ [3H]tyramine NCGC00016011-01 AM20060645 NCGC00016011-09 beta-(4-Hydroxyphenyl)ethylamine NCGC00063825-06 P-hydroxy-b-phenylethylamine BR-47332 Oprea1_294339 Phenethylamine, p-hydroxy- SPBio_000696 DivK1c_000918 2-(4-hydroxy-phenyl)ethylamine SR-01000075365-5 GTPL2148 21758-EP2298312A1 TC-060462 IDI1_000918 KB-62189 4-Hydroxy-.beta.-phenylethylamine Tyramine, 98%, FG KS-00000NMU a-(4-Hydroxyphenyl)-b-aminoethane Uteramine MCULE-3986856320 AJ-08146 NCGC00016011-04 AS-11671 NCGC00016011-12 Biomol-NT_000075 NINDS_000918 p-hydroxy-phenylethylamine BSPBio_002445 p-.beta.-Aminoethylphenol RTC-060462 CS-W007606 Spectrum3_000693 DSSTox_RID_80079 2-(4-Hydroxyphenyl)ethylamine STK531130 HMS2235J05 4- (2-aminoethyl)-Phenol Tox21_110282 TRA0098101 KBio2_004261 4-Hydroxy-beta-phenylethylamine Tyramine, free base Lopac-T-2879 AB0010532 ZINC2233 MLS000079096 alpha-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-07 BDBM29135 NCGC00063825-04 bmse000891 NSC249188 p-Tyramine CCG-39684 p-Hydroxy-.beta.-phenylethylamine SGCUT00017 D0C5RZ .beta.-(4-Hydroxyphenyl)ethylamine Spectrum_001213 EINECS 200-115-8 T-8910 HY-W007606 4-(2-Aminoethyl)-phenol(thyramin) 4-aminoethylphenol Tyramine base KBioGR_002405 51-67-2 Tyrosamine LS-103913 ACMC-1AQH1 NCGC00016011-02 AN-41614 NCGC00016011-10 beta-Hydroxyphenylethylamine NCGC00063825-07 p-Hydroxy-beta-phenethylamine BRD-K53893978-001-03-1 p-(2-aminoethyl)-Phenol Phenol, 4-(2-aminoethyl)- CHEMBL11608 SPECTRUM210400 DSSTox_CID_23874 2-(4-Hydroxyphenyl)-ethylamine ST24033343 GTPL2150 21758-EP2314571A2 Tenosin-wirkstoff InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H Tox21_110282_1 KBio1_000918 4-Hydroxy-b-phenylethylamine Tyramine, 99% KSC269I3J A0302 WLN: Z2R DQ MFCD00008193 AK-47332 NCGC00016011-05 b-(4-Hydroxyphenyl)ethylamine NCGC00016011-14 bmse000243 NSC 249188 p-Hydroxyphenethylamine C00483 p-beta-Aminoethylphenol SC-15191 CTK1G9434 (4-hydroxyphenyl)ethylamine Spectrum4_001801 DTXSID2043874 2-(p-Hydroxyphenyl)ethylamine SY002127 HMS502N20 4-(2-amino-ethyl)-phenol Tyramin KBio2_006829 4-Hydroxyphenethylamine Tyramine, Vetec(TM) reagent grade, 99% Lopac0_001136 AC1L1KQE [3H]-Tyramine MolPort-000-698-914 alpha.-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-08 Benzeneethanamine, 4-hydroxy- NCGC00063825-05 P-hydroxy-b-phenethylamine BPBio1_001394 Opera_ID_887 para-Tyramine CHEBI:15760 SMR000059295 DB08841 2-(4'-Hydroxyphenyl)ethylamine SR-01000075365 FT-0651978 21758-EP2281563A1 T-8911 I01-2032 4-(2-Aminoethyl)phenol 4-Hydroxy phenylethylamine Tyramine, 97% KBioSS_001693 51T672 UNII-X8ZC7V0OX3 M-3365 AEF NCGC00016011-03 ANW-31318 NCGC00016011-11 BIDD:ER0507 NCGC00063825-08 p-Hydroxy-beta-phenylethylamine BRN 1099914 p-(2-Aminoethyl)phenol Phenol, p-(2-aminoethyl)- cid_5610 Spectrum2_000738 DSSTox_GSID_43874 2-(4-hydroxyphenyl)ethanamine ST51037693 HMS1923C19 Tocosine KB-204477 [ Show all ]
Inchi Key	DZGWFCGJZKJUFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
PubChem CID	5610
ChEMBL	CHEMBL11608
IUPHAR	2148, 2150
BindingDB	29135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	50.1 nM	PubChem BioAssay data set	ChEMBL

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