Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●D-I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●D-QUARK ●DRfold ●DRfold2 ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●ATGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred ●TCRfinder

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●TM-search ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●DeepMSA2 ●rMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●HPmod ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	tyramine
Molecular formula	C8H11NO
IUPAC name	4-(2-aminoethyl)phenol
Molecular weight	137.182
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.1
Synonyms	AC1Q54AZ NCGC00016011-01 AM20060645 NCGC00016011-09 beta-(4-Hydroxyphenyl)ethylamine NCGC00063825-06 BR-47332 Oprea1_294339 DivK1c_000918 2-(4-hydroxy-phenyl)ethylamine GTPL2148 21758-EP2298312A1 IDI1_000918 4-13-00-01788 (Beilstein Handbook Reference) KBio3_001665 4-Hydroxyphenylethylamine LS-103895 p-Tyramine SGCUT00017 Spectrum_001213 T-8910 TRA0098101 Tyramine, free base ZINC2233 AJ-08146 NCGC00016011-04 AS-11671 NCGC00016011-12 Biomol-NT_000075 NINDS_000918 BSPBio_002445 p-.beta.-Aminoethylphenol CS-W007606 DSSTox_RID_80079 2-(4-Hydroxyphenyl)ethylamine HMS2235J05 4- (2-aminoethyl)-Phenol KB-62189 4-Hydroxy-.beta.-phenylethylamine KS-00000NMU a-(4-Hydroxyphenyl)-b-aminoethane MCULE-3986856320 p-Hydroxy-beta-phenethylamine Phenol, 4-(2-aminoethyl)- SPECTRUM210400 ST24033343 Tenosin-wirkstoff Tyramine base Tyrosamine MLS000079096 alpha-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-07 BDBM29135 NCGC00063825-04 bmse000891 NSC249188 CCG-39684 p-Hydroxy-.beta.-phenylethylamine D0C5RZ .beta.-(4-Hydroxyphenyl)ethylamine EINECS 200-115-8 HY-W007606 4-(2-Aminoethyl)-phenol(thyramin) KBio2_004261 4-Hydroxy-beta-phenylethylamine Lopac-T-2879 AB0010532 p-Hydroxyphenethylamine SC-15191 Spectrum4_001801 SY002127 Tox21_110282_1 Tyramine, 99% WLN: Z2R DQ ACMC-1AQH1 NCGC00016011-02 AN-41614 NCGC00016011-10 beta-Hydroxyphenylethylamine NCGC00063825-07 BRD-K53893978-001-03-1 p-(2-aminoethyl)-Phenol CHEMBL11608 DSSTox_CID_23874 2-(4-Hydroxyphenyl)-ethylamine GTPL2150 21758-EP2314571A2 InChI=1/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H 4-aminoethylphenol KBioGR_002405 51-67-2 LS-103913 P-hydroxy-b-phenethylamine para-Tyramine SMR000059295 SR-01000075365 T-8911 Tyramin Tyramine, Vetec(TM) reagent grade, 99% [3H]-Tyramine MFCD00008193 AK-47332 NCGC00016011-05 b-(4-Hydroxyphenyl)ethylamine NCGC00016011-14 bmse000243 NSC 249188 C00483 p-beta-Aminoethylphenol CTK1G9434 (4-hydroxyphenyl)ethylamine DTXSID2043874 2-(p-Hydroxyphenyl)ethylamine HMS502N20 4-(2-amino-ethyl)-phenol KBio1_000918 4-Hydroxy-b-phenylethylamine KSC269I3J A0302 p-Hydroxy-beta-phenylethylamine Phenol, p-(2-aminoethyl)- Spectrum2_000738 ST51037693 Tocosine Tyramine, 97% UNII-X8ZC7V0OX3 MolPort-000-698-914 alpha.-(4-Hydroxyphenyl)-beta-aminoethane NCGC00016011-08 Benzeneethanamine, 4-hydroxy- NCGC00063825-05 BPBio1_001394 Opera_ID_887 CHEBI:15760 DB08841 2-(4'-Hydroxyphenyl)ethylamine FT-0651978 21758-EP2281563A1 I01-2032 4-(2-Aminoethyl)phenol KBio2_006829 4-Hydroxyphenethylamine Lopac0_001136 AC1L1KQE p-Hydroxyphenylethylamine SCHEMBL4111 Spectrum5_000501 Systogene to_000085 Tyramine, analytical standard X8ZC7V0OX3 AEF NCGC00016011-03 ANW-31318 NCGC00016011-11 BIDD:ER0507 NCGC00063825-08 BRN 1099914 p-(2-Aminoethyl)phenol cid_5610 DSSTox_GSID_43874 2-(4-hydroxyphenyl)ethanamine HMS1923C19 KB-204477 4-Hydroxy phenylethylamine KBioSS_001693 51T672 M-3365 P-hydroxy-b-phenylethylamine Phenethylamine, p-hydroxy- SPBio_000696 SR-01000075365-5 TC-060462 Tyramine;4-(2-Amino-ethyl)-phenol [3H]tyramine MFCD00149002 AKOS000156022 NCGC00016011-06 BBL027695 NCGC00016011-16 bmse000870 NSC-249188 CAS-51-67-2 p-Hydroxy-.beta.-phenethylamine D01VFT .alpha.-(4-Hydroxyphenyl)-.beta.-aminoethane DZGWFCGJZKJUFP-UHFFFAOYSA-N HSDB 2132 4-(2-aminoethyl)-Phenol KBio2_001693 4-hydroxy-Benzeneethanamine L-Tyramine AB00051887-15 p-hydroxy-phenylethylamine RTC-060462 Spectrum3_000693 STK531130 Tox21_110282 Tyramine, 98%, FG Uteramine [ Show all ]
Inchi Key	DZGWFCGJZKJUFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2
PubChem CID	5610
ChEMBL	CHEMBL11608
IUPHAR	2150, 2148
BindingDB	29135
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<35000.0 nM	Bioorg. Med. Chem. Lett., (1997) 7:9:1207,	BindingDB,ChEMBL

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417