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Name | D(2) dopamine receptor |
---|---|
Species | Bos taurus (Bovine) |
Gene | DRD2 |
Synonym | Dopamine D2 receptor |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P20288 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3998 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL268558 |
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Molecular formula | C22H21ClN4 |
IUPAC name | 1-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[5,1-a]isoquinoline |
Molecular weight | 376.888 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 4.4 |
Synonyms | 4-(4-Chloro-phenyl)-1-pyrazolo[5,1-a]isoquinolin-1-ylmethyl-piperazin-1-ium 1-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[5,1-a]isoquinoline 1-[[4-(4-Chlorophenyl)piperazine-1-yl]methyl]pyrazolo[5,1-a]isoquinoline BDBM50073802 |
Inchi Key | DUEAFIKCLDPEGV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H21ClN4/c23-19-5-7-20(8-6-19)26-13-11-25(12-14-26)16-18-15-24-27-10-9-17-3-1-2-4-21(17)22(18)27/h1-10,15H,11-14,16H2 |
PubChem CID | 44263882 |
ChEMBL | CHEMBL268558 |
IUPHAR | N/A |
BindingDB | 50073802 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | <100000.0 nM | PMID9990464 | BindingDB,ChEMBL |
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