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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1771069
Molecular formulaC22H34N2O4S
IUPAC nametert-butyl 4-[1-(3-methylsulfonylphenyl)piperidin-4-yl]piperidine-1-carboxylate
Molecular weight422.584
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.7
Synonymstert-butyl 1''-(3-(methylsulfonyl)phenyl)-4,4''-bipiperidine-1-carboxylate
BDBM50342669
Inchi KeyDOONTXWGPCQFJL-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H34N2O4S/c1-22(2,3)28-21(25)24-14-10-18(11-15-24)17-8-12-23(13-9-17)19-6-5-7-20(16-19)29(4,26)27/h5-7,16-18H,8-15H2,1-4H3
PubChem CID54585806
ChEMBLCHEMBL1771069
IUPHARN/A
BindingDB50342669
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity>10.0 %PMID21273063ChEMBL

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