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GPCR

NameHistamine H2 receptor
SpeciesCavia porcellus (Guinea pig)
GeneHRH2
SynonymGastric receptor I
H2R
HH2R
DiseaseN/A for non-human GPCRs
Length359
Amino acid sequenceMAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProtP47747
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2882
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL128585
Molecular formulaC17H21N3O2
IUPAC name3-(1H-imidazol-5-yl)propyl N-[cyclopropyl(phenyl)methyl]carbamate
Molecular weight299.374
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.7
Synonyms(Cyclopropyl-phenyl-methyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester;0.8C2H2O4
BDBM50118162
Inchi KeyAISUIUPQHGHDCK-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H21N3O2/c21-17(22-10-4-7-15-11-18-12-19-15)20-16(14-8-9-14)13-5-2-1-3-6-13/h1-3,5-6,11-12,14,16H,4,7-10H2,(H,18,19)(H,20,21)
PubChem CID11748564
ChEMBLCHEMBL128585
IUPHARN/A
BindingDB50118162
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
pD'24.2 -PMID12190321ChEMBL

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