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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2431110
Molecular formula	C17H22N4O2
IUPAC name	2-cyclopropyl-6,7-dimethoxy-4-piperazin-1-ylquinazoline
Molecular weight	314.389
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.9
Synonyms	SCHEMBL19773006 BDBM50440739 MLS-0471510.0001
Inchi Key	DNVUUDPAIIWHMU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H22N4O2/c1-22-14-9-12-13(10-15(14)23-2)19-16(11-3-4-11)20-17(12)21-7-5-18-6-8-21/h9-11,18H,3-8H2,1-2H3
PubChem CID	56593292
ChEMBL	CHEMBL2431110
IUPHAR	N/A
BindingDB	50440739
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<40000.0 nM	PMID24611085	BindingDB,ChEMBL

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