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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL1743950
Molecular formula	C22H21N3
IUPAC name	2-(2-quinolin-2-ylethyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole
Molecular weight	327.431
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.2
Synonyms	AIQHLPHYTDDMQV-UHFFFAOYSA-N CHEMBL52653 2,3,4,5-Tetrahydro-2-[2-(2-quinolinyl)ethyl]-1H-pyrido[4,3-b]indole BDBM50367424 SCHEMBL10377299
Inchi Key	AIQHLPHYTDDMQV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21N3/c1-3-7-20-16(5-1)9-10-17(23-20)11-13-25-14-12-22-19(15-25)18-6-2-4-8-21(18)24-22/h1-10,24H,11-15H2
PubChem CID	13772444
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50367424
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	331.0 nM	PMID2888898	BindingDB

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