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GPCR

Name	Metabotropic glutamate receptor 2
Species	Homo sapiens (Human)
Gene	GRM2
Synonym	mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor
Disease	Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder Psychiatric disorder Schizophrenia Alzheimer disease; Major depressive disorder [ Show all ]
Length	872
Amino acid sequence	MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	Q14416
Protein Data Bank	5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5cnj.
BioLiP	BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target Database	T62820
ChEMBL	CHEMBL5137
IUPHAR	290
DrugBank	N/A

Ligand

Name	(RS)-MCPG
Molecular formula	C10H11NO4
IUPAC name	4-(1-amino-1-carboxyethyl)benzoic acid
Molecular weight	209.201
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-2.0
Synonyms	(+/-)-alpha-Methyl-4-carboxyphenylglycine (y)-alpha-Methyl-4-carboxyphenylglycine AC1Q5S1R Benzeneacetic acid, a-amino-4-carboxy-a-methyl- CS-5708 Lopac0_000747 NCGC00015676-05 SR-01000075733 (?)-alpha-Methyl-4-carboxyphenylglycine 4-(1-Amino-1-carboxy-ethyl)-benzoic acid(S-M4CPG) alpha-Amino-4-carboxy-alpha-methylbenzeneacetic acid BN0322 HMS3262E16 M 4796 NCGC00024542-03 Tox21_500747 (+-)-MCPG (RS)-?-Methyl-4-carboxyphenylglycine BCP18268 KS-00001CLO NCGC00015676-03 RT-015311 (+/-)-MCPG ACMC-20cchr Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl- CTK4C5052 LP00747 NCGC00015676-06 SR-01000075733-1 ( inverted question mark)-alpha-Methyl-4-carboxyphenylglycine (r,s)-alpha-methyl-4-carboxyphenylglycine 4-(1-amino-1-carboxyethyl)benzoic acid alpha-Methyl-2-(4-carboxyphenyl)glycine C10H11NO4 HY-100371 MFCD00210205 NCGC00024542-04 (+/-)-alpha-Methyl-(4-carboxyphenyl)glycine AC1L1AZT BDBM50030627 CHEMBL299683 L000020 NCGC00015676-04 SCHEMBL715285 (+/-)MCPG 146669-29-6 AKOS005066801 Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-, (+-)- EU-0100747 LS-173280 NCGC00024542-02 ST50825577 ( inverted question mark)-MCPG (R,S)-MCPG 4-(2-amino-1-hydroxy-1-oxopropan-2-yl)benzoic acid alpha-Methyl-4-carboxyphenylglycine CCG-204832 J-008240 MolPort-003-958-752 NCGC00261432-01 [ Show all ]
Inchi Key	DNCAZYRLRMTVSF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)
PubChem CID	1222
ChEMBL	CHEMBL299683
IUPHAR	N/A
BindingDB	50030627
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	50000.0 nM	PMID8667369	BindingDB,ChEMBL
IC50	340000.0 nM	PMID7562903	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID7515823, PMID8863838, PMID9131252, PMID9463480	PDSP,BindingDB
Ki	334.0 nM	PMID9832156	BindingDB
Ki	51000.0 nM	PMID10893301	BindingDB,ChEMBL
Ki	340000.0 nM	PMID10893301	BindingDB,ChEMBL

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