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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesRattus norvegicus (Rat)
GeneChrm2
Synonymcholinergic receptor
cholinergic receptor, muscarinic 2
AChR M2
Chrm-2
M2 muscarinic acetylcholine receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP10980
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL309
IUPHAR14
DrugBankN/A

Ligand

NameCHEMBL3298598
Molecular formulaC18H21ClIN3O2S
IUPAC name[(3R)-1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl] N-[5-(3-chlorophenyl)-1,3-thiazol-4-yl]carbamate;iodide
Molecular weight505.799
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogPNone
SynonymsBDBM50021926
Inchi KeyDMYMHWZDYNBJLD-CUTBRAQKSA-N
Inchi IDInChI=1S/C18H20ClN3O2S.HI/c1-22-7-5-12(6-8-22)15(10-22)24-18(23)21-17-16(25-11-20-17)13-3-2-4-14(19)9-13;/h2-4,9,11-12,15H,5-8,10H2,1H3;1H/t12?,15-,22?;/m0./s1
PubChem CID90645358
ChEMBLCHEMBL3298598
IUPHARN/A
BindingDB50021926
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki1.2 nMPMID24837158BindingDB,ChEMBL

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