You can:
Name | Neurotensin receptor type 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | NTSR2 |
Synonym | levocabastine-sensitive neurotensin receptor neurotensin receptor type 2 high-affinity levocabastine-sensitive neurotensin receptor NT2R NTR2 [ Show all ] |
Disease | N/A |
Length | 410 |
Amino acid sequence | METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT |
UniProt | O95665 |
Protein Data Bank | N/A |
GPCR-HGmod model | O95665 |
3D structure model | This predicted structure model is from GPCR-EXP O95665. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2514 |
IUPHAR | 310 |
DrugBank | N/A |
Name | CHEMBL2431237 |
---|---|
Molecular formula | C28H30N4O3 |
IUPAC name | 6-ethoxy-7-methoxy-4-[4-(4-methoxyphenyl)piperazin-1-yl]-2-phenylquinazoline |
Molecular weight | 470.573 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 5.5 |
Synonyms | BDBM50440751 |
Inchi Key | DJMMEPKHPYUUFQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H30N4O3/c1-4-35-26-18-23-24(19-25(26)34-3)29-27(20-8-6-5-7-9-20)30-28(23)32-16-14-31(15-17-32)21-10-12-22(33-2)13-11-21/h5-13,18-19H,4,14-17H2,1-3H3 |
PubChem CID | 73355398 |
ChEMBL | CHEMBL2431237 |
IUPHAR | N/A |
BindingDB | 50440751 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <80000.0 nM | PMID24611085 | ChEMBL |
zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417