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GPCR

Name	P2Y purinoceptor 6
Species	Homo sapiens (Human)
Gene	P2RY6
Synonym	pyrimidinergic receptor P2Y P2Y6 receptor P2Y6 P2Y purinoceptor 6 P2Y ATP receptor 6 uridine nucleotide receptor [ Show all ]
Disease	N/A
Length	328
Amino acid sequence	MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR
UniProt	Q15077
Protein Data Bank	N/A
GPCR-HGmod model	Q15077
3D structure model	This predicted structure model is from GPCR-EXP Q15077.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4714
IUPHAR	326
DrugBank	N/A

Ligand

Name	Azure KX
Molecular formula	C23H12Cl2N6Na2O8S2
IUPAC name	disodium;1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfonatoanilino]-9,10-dioxoanthracene-2-sulfonate
Molecular weight	681.383
Hydrogen bond acceptor	14
Hydrogen bond donor	3
XlogP	None
Synonyms	Modr Brilantni Ostazinova S-R [Czech] W-109977 2-Anthracenesulfonic acid, 1-amino-4-((3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-, disodium salt 872P30Z43F CTK8I7730 PSB-1011 12627-07-5 2-Anthracenesulfonic acid, 1-amino-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl]amino]-9,10-dihydro-9,10-dioxo-, sodium salt (1:2) disodium 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfonatoanilino]-9,10-dioxoanthracene-2-sulfonate LS-31856 SCHEMBL4360990 1345690-39-2 4499-01-8 Procion Brilliant Blue M-RS 2-Anthracenesulfonic acid, 1-amino-4-((3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-sulfophenyl)amino)-9,10-dihydro-9,10-dioxo-, sodium salt (1:2) AC1L2UTR Disodium 1-amino-4-(3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-sulphonatoanilino)-9,10-dihydro-9,10-dioxoanthracene-2-sulphonate DTXSID5063497 Reactive Brilliant Blue KKh 12640-43-6 2-Anthraquinonesulfonic acid, 1-amino-4-((3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-sulfophenyl)amino)-, disodium salt Benzenesulfonic acid, 2-(4,6-dichloro-s-triazin-2-ylamino)-4-(4-amino-3-sulfo-1-anthraquinonylamino)-, disodium salt Modr Brilantni Ostazinova S-R UNII-872P30Z43F 2-Anthracenesulfonic acid, 1-amino-4-((3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-sulfophenyl)amino)-9,1 0-dihydro-9,10-dioxo-, disodium salt 53126-07-1 CHEMBL1672104 PROCION BRILLIANT BLUE MRS 106395-95-3 2-Anthracenesulfonic acid, 1-amino-4-[[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfophenyl]amino]-9,10-dihydro-9,10-dioxo-, disodium salt AN-21038 disodium 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulfonato-anilino]-9,10-dioxo-anthracene-2-sulfonate EINECS 224-797-1 Reactive Sky Blue KKh 13324-20-4 (Parent) 2Na 1-amino-4-[3-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]-4-sulphonatoanilino]-9,10-2H-9,10-dioxoanthracene-2-sulphonate C.i. reactive Blue 4, disodium salt [ Show all ]
Inchi Key	DHHMYWVFMSHEIP-UHFFFAOYSA-L
Inchi ID	InChI=1S/C23H14Cl2N6O8S2.2Na/c24-21-29-22(25)31-23(30-21)28-12-7-9(5-6-14(12)40(34,35)36)27-13-8-15(41(37,38)39)18(26)17-16(13)19(32)10-3-1-2-4-11(10)20(17)33;;/h1-8,27H,26H2,(H,34,35,36)(H,37,38,39)(H,28,29,30,31);;/q;2*+1/p-2
PubChem CID	78253
ChEMBL	CHEMBL1672104
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID21207957	ChEMBL

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