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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	MLS000123585
Molecular formula	C15H12N4O
IUPAC name	6-benzyl-5-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Molecular weight	264.288
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	1.9
Synonyms	5-methyl-7-oxo-6-(phenylmethyl)-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile AKOS000550265 HMS2473A13 SR-01000320103 6-benzyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile BDBM37820 MolPort-000-823-359 STK584829 ZINC5730157 767323-14-8 cid_754780 SCHEMBL902395 6-benzyl-5-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile AKOS005507990 MCULE-2846074959 SR-01000320103-1 6-benzyl-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile CCG-114953 MolPort-002-001-218 UNM000003580301 5-methyl-7-oxidanylidene-6-(phenylmethyl)-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile AC1LFJI4 EU-0015346 SMR000124167 6-Benzyl-5-methyl-7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carbonitrile BAS 05427581 STK186197 6-benzyl-7-keto-5-methyl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile CHEMBL1519083 SCHEMBL16077817 ZINC100630210 [ Show all ]
Inchi Key	DGLODFBTANILDO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H12N4O/c1-10-13(7-11-5-3-2-4-6-11)15(20)19-14(18-10)12(8-16)9-17-19/h2-6,9,17H,7H2,1H3
PubChem CID	754780
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37820
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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