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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Sus scrofa (Pig)
Gene	EDNRA
Synonym	Endothelin receptor type A {ECO:0000250\|UniProtKB:P25101} ET-A ET-AR
Disease	N/A for non-human GPCRs
Length	427
Amino acid sequence	METFCFRVSFWVALLGCVISDNPESHSTNLSTHVDDFTTFRGTEFSLVVTTHRPTNLALPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFENHDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEEHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHEQNNHNTERSSHKDSIN
UniProt	Q29010
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4130
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL326380
Molecular formula	C31H31N5O4S2
IUPAC name	4-tert-butyl-N-[5-(4-methylphenyl)-6-[2-(5-thiophen-3-ylpyrimidin-2-yl)oxyethoxy]pyrimidin-4-yl]benzenesulfonamide
Molecular weight	601.74
Hydrogen bond acceptor	10
Hydrogen bond donor	1
XlogP	6.6
Synonyms	SCHEMBL7069449 L013089 N-[5-(4-Methylphenyl)-6-[2-[5-(3-thienyl)-2-pyrimidinyloxy]ethoxy]-4-pyrimidinyl]-4-tert-butylbenzenesulfonamide
Inchi Key	DDDLHQVGWTUWPG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H31N5O4S2/c1-21-5-7-22(8-6-21)27-28(36-42(37,38)26-11-9-25(10-12-26)31(2,3)4)34-20-35-29(27)39-14-15-40-30-32-17-24(18-33-30)23-13-16-41-19-23/h5-13,16-20H,14-15H2,1-4H3,(H,34,35,36)
PubChem CID	9894972
ChEMBL	CHEMBL326380
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	>0.001 nM	PMID11585441	ChEMBL

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