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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	clozapine
Molecular formula	C18H19ClN4
IUPAC name	3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
Molecular weight	326.828
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.1
Synonyms	GP7633 BCP25196 HMS1791P12 Bio2_000790 HMS3260H14 CAS-5786-21-0 HY-14539 Clopine (TN) Clozapine 1.0 mg/ml in Acetonitrile Clozapine, British Pharmacopoeia (BP) Reference Standard 8-Chloro-11-(4-methyl)-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine Clozaril (TN) 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine( Clozepine ) DB00363 AB00052158_15 EN300-52510 AKOS026749900 W-801 NCGC00015254-02 NCGC00015254-10 NCGC00015254-18 NCGC00022902-09 NSC-757429 REGID_for_CID_2818 KBio2_000599 SCHEMBL8397 KBioGR_000310 Spectrum_000139 Leponex Tocris-0444 MCULE-3665900006 AOB5635 HF 1854 BG0154 HMS2089L13 BRN 0764984 HMS3402P12 CCRIS 9171 J60AR2IKIC Clozapina 3-chloro-6-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Clozapine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- Clozapine, solid 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine CTK6I2968 8-chloro-11-(4-methylpiperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine DSSTox_CID_2855 AB1009321 Fazaclo (TN) MLS001077282 ZINC19796155 NCGC00015254-05 NCGC00015254-13 NCGC00022902-04 NCGC00022902-12 Pharmakon1600-01500685 SAM002589962 KBio2_005446 SPBio_002340 KBioSS_000599 SR-01000000096-4 LEX-123 Tox21_500276 FT-0082373 Azaleptine HMS1361P12 Bio1_001414 HMS2235E19 C06924 HMS501B05 Clozapine (Clozaril) 3-Hydroxy-2-phenyl-propionic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester clozapine(tautomer) 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene Clozapinum [INN-Latin] 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine D0Z1RV AB00052158-13 DTXSID5022855 AC1Q3ZWP W-105432 NC00667 NCGC00015254-08 NCGC00015254-16 NCGC00022902-07 NCGC00260961-01 Prestwick_693 KBio1_000343 SC-26976 KBio3_000620 Spectrum3_001828 L000195 SW220247-1 LS-60881 AN-16004 GTPL38 BDBM22869 HMS1921C16 BRD-K37289225-001-09-1 HMS3266A10 CC0176 I06-0047 Clorazil (E)-8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine Clozapine for peak identification, European Pharmacopoeia (EP) Reference Standard 5786-21-0 Clozapine, drug standard, 1.0 mg/mL in methanol 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine CPD000058365 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Ciozapine) Denzapine (TN) AB00052158_16 EU-0100276 Z1245633277 NCGC00015254-03 NCGC00015254-11 NCGC00015254-20 NCGC00022902-10 NSC757429 s2459 KBio2_002878 SMR000058365 KBioGR_001336 SR-01000000096 Leponex (TN) Tox21_110113 MFCD00153785 Asaleptin HF-1854 Bio1_000436 HMS2092I16 C 6305 HMS3657E15 CHEBI:3766 Clozapina [INN-Spanish] 3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine Clozapine [USAN:INN:BAN] 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0(3),]pentadeca-1,3,5,7,10,12,14-heptaene Clozapine, United States Pharmacopeia (USP) Reference Standard 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine D-107 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine DSSTox_GSID_22855 AC1L1EJE Fazaclo ODT MolPort-001-728-041 ZINC3872123 NCGC00015254-06 NCGC00015254-14 NCGC00022902-05 NCGC00022902-13 Prestwick0_000350 SBI-0050264.P004 KBio2_005735 SPECTRUM1500685 Klozapol (TN) SR-01000000096-5 Lopac-C-6305 UNII-J60AR2IKIC FT-0600382 BC204168 HMS1569E21 Bio2_000310 HMS3259J17 C18H19ClN4 HSDB 6478 CHEMBL42 Clozapine (JAN/USP/INN) CLOZAPINE, 8-CHLORO-11-(4-METHYL-PIPERAZIN-1-YL)-5H-DIBENZO[B,E][1,4]DIAZEPINE 786C210 CLOZARIL 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (Clozapine) AB00052158-14 EINECS 227-313-7 AKOS005064444 W-2845 NCGC00015254-01 NCGC00015254-09 NCGC00015254-17 NCGC00022902-08 NINDS_000343 QZUDBNBUXVUHMW-UHFFFAOYSA-N KBio2_000310 SCHEMBL33323 KBio3_002979 Spectrum4_000898 L013417 TC-063560 LX 100-129 ANW-42470 H482 BDBM50001884 HMS1989P12 BRD-K37289225-001-23-2 HMS3371H05 CCG-39881 Iprox Clozapin 1333667-72-3 Clozapine Resolution Mixture, United States Pharmacopeia (USP) Reference Standard 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)- Clozapine, European Pharmacopoeia (EP) Reference Standard 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine CS-0644 8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine(Clopazine) DivK1c_000343 AB0013069 Fazaclo MLS000028472 Zaponex (TN) NCGC00015254-04 NCGC00015254-12 NCGC00022902-02 NCGC00022902-11 Opera_ID_482 SAM002548976 KBio2_003167 SPBio_000798 KBioSS_000310 SR-01000000096-2 Lepotex Tox21_110113_1 Froidir (TN) Azaleptin HF1854 Bio1_000925 HMS2096E21 C-36335 HMS3713E21 CHEBI:92657 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine Clozapine [USAN:USP:INN:BAN] 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaene Clozapinum 8-chloro-11-(4-methyl-piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine D00283 8-Chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine DSSTox_RID_76759 AC1Q3OPZ MolPort-006-167-528 NCGC00015254-07 NCGC00015254-15 NCGC00022902-06 NCGC00188978-01 Prestwick1_000350 SC-12183 KBio3_000619 Spectrum2_000919 KS-1166 SR-01000000096-8 LP00276 Versacloz [ Show all ]
Inchi Key	QZUDBNBUXVUHMW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
PubChem CID	135398737
ChEMBL	CHEMBL42
IUPHAR	38
BindingDB	50001884
DrugBank	DB00363
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	250.0 nM	None	ChEMBL
IC50	6.039 nM	DrugMatrix in vitro pharmacology data	ChEMBL
IC50	10.0 nM	PMID9622542	BindingDB,ChEMBL
Ki	1.99526 - 39.8107 nM	PMID9732398, PMID15322733, PMID12629531, PMID15102927, PMID10991983, PMID10217294	IUPHAR
Ki	2.884 nM	PMID15261283, Med Chem Res, (2013) 22:2:520	ChEMBL
Ki	3.163 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	4.8 nM	PMID25343529	BindingDB,ChEMBL
Ki	5.0 nM	PMID11170639	BindingDB,ChEMBL
Ki	5.012 nM	PMID11101359	ChEMBL
Ki	7.943 nM	PMID17880057	ChEMBL
Ki	9.3 nM	PMID23301527	BindingDB,ChEMBL
Ki	9.333 nM	PMID23301527	ChEMBL
Ki	10.0 nM	PMID14741248	BindingDB
Ki	10.47 nM	PMID17588750, PMID19796944, PMID14741248, PMID18783204	BindingDB,ChEMBL
Ki	13.0 nM	, PMID24559051, None, PMID14998318	BindingDB,ChEMBL
Ki	15.0 nM	PMID20719507	BindingDB,ChEMBL
Ki	15.85 nM	PMID10425088, PMID11754579	ChEMBL
Ki	17.0 nM	PMID18595716	BindingDB,ChEMBL
Ki	21.0 nM	PMID15771415	BindingDB,ChEMBL
Ki	23.0 nM	PMID23792350	ChEMBL
Ki	24.0 nM	PMID23353740	BindingDB,ChEMBL
Ki	72.44 nM	PMID23301527	ChEMBL
Ki	73.0 nM	PMID23301527	BindingDB,ChEMBL
Ki	100.0 nM	MedChemComm, (2012) 3:5:580	ChEMBL

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