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GPCR

Name	Type-1 angiotensin II receptor
Species	Homo sapiens (Human)
Gene	AGTR1
Synonym	Type-1 angiotensin II receptor HAT1R Agtr-1a type-1A angiotensin II receptor AT1 type-1B angiotensin II receptor vascular type-1 angiotensin II receptor AT3 AT2R1A AG2S Agtr-1b Agtr1 angiotensin II receptor angiotensin II receptor, type 1 angiotensin II receptor, type 1a angiotensin II receptor, type 1b angiotensin II type-1 receptor angiotensin II type-1A receptor AT2R1 AT1BR AT1AR AT1 receptor Angtr-1b Angtr-1a angiotensin II type-1B receptor [ Show all ]
Disease	Metabolic syndrome x Myocardial infarction Hypertension Restenosis Alzheimer disease High blood pressure Heart failure Unspecified Hypotension [ Show all ]
Length	359
Amino acid sequence	MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
UniProt	P30556
Protein Data Bank	6do1, 4zud, 4yay
GPCR-HGmod model	P30556
3D structure model	This structure is from PDB ID 6do1.
BioLiP	BL0312790, BL0326733, BL0439004,BL0439005
Therapeutic Target Database	T74456
ChEMBL	CHEMBL227
IUPHAR	34
DrugBank	BE0000062

Ligand

Name	(4,6-diphenylpyrimidin-2-yl)hydrazine
Molecular formula	C16H14N4
IUPAC name	(4,6-diphenylpyrimidin-2-yl)hydrazine
Molecular weight	262.316
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.1
Synonyms	(4,6-diphenyl-2-pyrimidinyl)hydrazine AC1M49QR CTK7F1728 SCHEMBL2401750 BDBM67270 HMS1394O14 5588-58-9 CHEMBL1375248 MLS000856324 (4,6-Diphenyl-pyrimidin-2-yl)-hydrazine AKOS001016733 DTXSID40367886 SMR000279269 2-HYDRAZINO-4,6-DIPHENYL-PYRIMIDINE CBDivE_006945 HMS2686O04 cid_2303647 MolPort-001-915-228 (4,6-diphenylpyrimidin-2-yl)diazane BAS 00117023 Enamine_000322 ZINC3091431 4,6-diphenylpyrimidin-2-ylhydrazine MCULE-8342616212 [ Show all ]
Inchi Key	DBYCDKBEVKWZNL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H14N4/c17-20-16-18-14(12-7-3-1-4-8-12)11-15(19-16)13-9-5-2-6-10-13/h1-11H,17H2,(H,18,19,20)
PubChem CID	2303647
ChEMBL	CHEMBL1375248
IUPHAR	N/A
BindingDB	67270
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	12956.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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