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Name | Somatostatin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | SSTR2 |
Synonym | somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R [ Show all ] |
Disease | Acromegaly Lung cancer Neuroendocrine cancer |
Length | 369 |
Amino acid sequence | MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI |
UniProt | P30874 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30874 |
3D structure model | This predicted structure model is from GPCR-EXP P30874. |
BioLiP | N/A |
Therapeutic Target Database | T53024 |
ChEMBL | CHEMBL1804 |
IUPHAR | 356 |
DrugBank | BE0003528 |
Name | BDBM84625 |
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Molecular formula | C49H67N11O10 |
IUPAC name | (2S)-6-amino-N-[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide |
Molecular weight | 970.142 |
Hydrogen bond acceptor | 12 |
Hydrogen bond donor | 13 |
XlogP | -0.5 |
Synonyms | BIM 23051 |
Inchi Key | GVSJBZZGXKEBGH-KFMCEEOESA-N |
Inchi ID | InChI=1S/C49H67N11O10/c1-27(54-45(66)35(51)23-31-15-7-5-8-16-31)43(64)57-38(24-32-17-9-6-10-18-32)47(68)58-39(25-33-26-53-36-20-12-11-19-34(33)36)48(69)56-37(21-13-14-22-50)46(67)60-41(30(4)62)49(70)55-28(2)44(65)59-40(29(3)61)42(52)63/h5-12,15-20,26-30,35,37-41,53,61-62H,13-14,21-25,50-51H2,1-4H3,(H2,52,63)(H,54,66)(H,55,70)(H,56,69)(H,57,64)(H,58,68)(H,59,65)(H,60,67)/t27-,28-,29+,30?,35+,37-,38-,39+,40-,41-/m0/s1 |
PubChem CID | 57339790 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 84625 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1000.0 nM | PMID7988476 | BindingDB |
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