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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	DIHYDREXIDINE
Molecular formula	C17H17NO2
IUPAC name	5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol
Molecular weight	267.328
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.5
Synonyms	AC1L1TV8 D0D3VT SCHEMBL4614578 Benzo(a)phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel- L000828 10,11-Dihydroxyhexahydrobenzo(a)phenanthridine CHEBI:91996 PDSP1_000570 5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine-10,11-diol AC1Q7A2Z Benzo(a)phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, trans- LS-186899 137417-08-4 CHEMBL101446 PDSP2_000568 BDBM50049047 Dihydrexidine, DHX BRD-A99164655-003-01-5 LS-187553 5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol [ Show all ]
Inchi Key	BGOQGUHWXBGXJW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2
PubChem CID	60759
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50049047
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	24.0 nM	PMID12628671	BindingDB
Ki	43.2 nM	PMID15492773	BindingDB
Ki	43.8 nM	PMID15492773	BindingDB
Ki	50.0 nM	PMID15492773	BindingDB
Ki	58.1 nM	PMID12628671	BindingDB
Ki	122.0 nM	PMID15492773	BindingDB
Ki	180.0 nM	PMID12628671	BindingDB
Ki	660.0 nM	PMID15492773	BindingDB
Ki	1490.0 nM	PMID12628671	BindingDB

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