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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Succinate receptor 1
Species	Homo sapiens (Human)
Gene	SUCNR1
Synonym	succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 G-protein coupled receptor 91 G protein-coupled receptor 91 SUCNR1 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProt	Q9BXA5
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXA5
3D structure model	This predicted structure model is from GPCR-EXP Q9BXA5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150838
IUPHAR	166
DrugBank	BE0002258

Ligand

Name	Methylmalonic acid
Molecular formula	C4H6O4
IUPAC name	2-methylpropanedioic acid
Molecular weight	118.088
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.1
Synonyms	SY006109 516-05-2 AI3-19472 BBL027393 CS-0027817 HY-103395 LS41650 methyl-Propanedioic acid methylpropanedioate NSC25201 2-methyl-propanedioic acid 2-Methylpropanedioic acid UNII-8LL8S712J7 AKOS009157181 bmse000398 DTXSID00199549 Isosuccinic acid MCULE-7232226851 Methylmalonic acid solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material MLS001335866 SC-16059 21531-EP2314295A1 ZIYVHBGGAOATLY-UHFFFAOYSA-N AC1Q5RNP ANW-31301 CHEBI:30860 GTPL9633 LMFA01170118 methyl-Malonic acid MethylmalonicAcid NSC 25201 166A2535-D607-4D47-956D-8FC6A1EA3B08 ST24040904 TR-032107 516M052 AJ-24348 BCP22931 CTK1G9635 InChI=1/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8 M0568 methylmalonate methylpropanedioic acid Propanedioic acid, methyl- 2-Methylmalonate 21531-EP2289876A1 WLN: QV1VO1 AB0011957 alpha-methylmalonic acid BRN 1756084 EINECS 208-219-5 KB-69062 METHYL MALONIC ACID Methylmalonic acid, 96% MolPort-003-938-570 1,1-Ethanedicarboxylate SCHEMBL27766 STL373471 4-02-00-01932 (Beilstein Handbook Reference) ACMC-209kuv B7725 CHEMBL1232416 HMS2230A22 LS-88826 methyl-Propanedioate methylmalons NSC-25201 2-methyl-malonic acid TRA0069742 8LL8S712J7 AK-82572 BDBM50038341 DB04183 Isosuccinate Malonic acid, methyl- MLS001335865 Propanedioic acid, methyl- (9CI) 2-Methylmalonic acid 21531-EP2298768A1 ZINC901289 AC1L19CG AN-5001 C02170 FT-0655314 KS-00000CI8 methyl-Malonate Methylmalonic acid, 99% NCGC00247049-01 1,1-Ethanedicarboxylic acid SMR000857347 [ Show all ]
Inchi Key	ZIYVHBGGAOATLY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8)
PubChem CID	487
ChEMBL	N/A
IUPHAR	9633
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	169000.0 nM	PMID28160606	IUPHAR
EC50	284000.0 nM	PMID15141213	IUPHAR

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