Zhang Lab

National University of Singapore

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Lysophosphatidic acid receptor 3
Species	Mus musculus (Mouse)
Gene	Lpar3
Synonym	Edg7 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 LPA receptor 3 LPA-3 LPA3 receptor Lysophosphatidic acid receptor Edg-7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLTASLANLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVAVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCALQDSNTERRPSRNPSTIHSRSETGSQYLEDSISQGPVCNKNGS
UniProt	Q9EQ31
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	274
DrugBank	N/A

Ligand

Name	lysophosphatidic acid
Molecular formula	C21H41O7P
IUPAC name	(2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	(2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoate 1-Oleoyl-lyso-phosphatidate 22002-87-5 CMC_8485 Lysophosphophatidic acid WRGQSWVCFNIUNZ-KTKRTIGZSA-N 1-(9Z-octadecenoyl)-phosphatidic acid 1-oleoyl-lysophosphatidic acid 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester DTXSID5041061 Olein, 1-mono-, 3-(dihydrogen phosphate) (8CI) [3H]LPA 1-oleoyl-glycero-3-phosphate 2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate AKOS030561932 GTPL5395 Oleoyl lysophosphatidic acid (2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoic acid 1-Oleoyl-lyso-phosphatidic acid D0X0UR monooleylphosphatidate [3H]-LPA 1-monooleoylglycerol 3-phosphate 1-Oleyllysophosphatidate 9-octadecenoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (9Z)- EINECS 244-710-0 Olein, 1-mono-, 3-phosphate (7CI) [3H]lysophosphatidic acid 1-oleoyl-LPA 2-Hydroxy-3-(phosphonooxy)propyl oleate cis-9-Octadecenoic acid 2-hydroxy-3-phosphonooxypropyl ester SCHEMBL1548 (2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate 1-Oleoyl-lysophosphatidate 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester (9CI) D0Z9FO Monooleylphosphatidic acid [3H]1-oleoyl-LPA 1-Oleoyl-2-lysophosphatidic acid 1-Oleyllysophosphatidic acid AC1NUZKL GTPL2906 Oleoyl lysophosphatidate {2-hydroxy-3-[(9Z)-octadec-9-enoyloxy]propoxy}phosphonic acid [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-KTKRTIGZSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
PubChem CID	5497152
ChEMBL	N/A
IUPHAR	2906
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	253.0 nM	PMID18781939	IUPHAR

zhanglabzhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417