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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Sphingosine 1-phosphate receptor 1
Species	Homo sapiens (Human)
Gene	S1PR1
Synonym	Sphingosine 1-phosphate receptor Edg-1 S1P1 receptor S1P1 S1P receptor Edg-1 S1P receptor 1 CD363 EDG1 (Edg1) endothelial differentiation G protein-coupled receptor 1 Endothelial differentiation G-protein coupled receptor 1 [ Show all ]
Disease	Immune disorder Macular degeneration Hepatocellular carcinoma; Multiple scierosis Multiple scierosis Primary progressive multiple sclerosis Cutaneous lupus erythematosus Psoriasis Cardiovascular disorder Cancer Autoimmune diabetes Advanced non-small cell lung cancer Acne vulgaris Rheumatoid arthritis Inflammatory disease [ Show all ]
Length	382
Amino acid sequence	MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
UniProt	P21453
Protein Data Bank	3v2w
GPCR-HGmod model	P21453
3D structure model	This structure is from PDB ID 3v2w.
BioLiP	BL0214678
Therapeutic Target Database	T13852
ChEMBL	CHEMBL4333
IUPHAR	275
DrugBank	N/A

Ligand

Name	lysophosphatidic acid
Molecular formula	C21H41O7P
IUPAC name	(2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate
Molecular weight	436.526
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	5.2
Synonyms	1-oleoyl-LPA 2-Hydroxy-3-(phosphonooxy)propyl oleate cis-9-Octadecenoic acid 2-hydroxy-3-phosphonooxypropyl ester SCHEMBL1548 (2-hydroxy-3-phosphonooxypropyl) (Z)-octadec-9-enoate 1-Oleoyl-lysophosphatidate 9-Octadecenoic acid (9Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester (9CI) D0Z9FO Monooleylphosphatidic acid [3H]1-oleoyl-LPA 1-Oleoyl-2-lysophosphatidic acid 1-Oleyllysophosphatidic acid AC1NUZKL GTPL2906 Oleoyl lysophosphatidate {2-hydroxy-3-[(9Z)-octadec-9-enoyloxy]propoxy}phosphonic acid (2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoate 1-Oleoyl-lyso-phosphatidate 22002-87-5 CMC_8485 Lysophosphophatidic acid WRGQSWVCFNIUNZ-KTKRTIGZSA-N 1-(9Z-octadecenoyl)-phosphatidic acid 1-oleoyl-lysophosphatidic acid 9-Octadecenoic acid (Z)-, 2-hydroxy-3-(phosphonooxy)propyl ester DTXSID5041061 Olein, 1-mono-, 3-(dihydrogen phosphate) (8CI) [3H]LPA 1-oleoyl-glycero-3-phosphate 2-hydroxy-3-(phosphonooxy)propyl (9Z)-octadec-9-enoate AKOS030561932 GTPL5395 Oleoyl lysophosphatidic acid (2-hydroxy-3-phosphonooxypropyl) (E)-octadec-9-enoic acid 1-Oleoyl-lyso-phosphatidic acid D0X0UR monooleylphosphatidate [3H]-LPA 1-monooleoylglycerol 3-phosphate 1-Oleyllysophosphatidate 9-octadecenoic acid, 2-hydroxy-3-(phosphonooxy)propyl ester, (9Z)- EINECS 244-710-0 Olein, 1-mono-, 3-phosphate (7CI) [3H]lysophosphatidic acid [ Show all ]
Inchi Key	WRGQSWVCFNIUNZ-KTKRTIGZSA-N
Inchi ID	InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-
PubChem CID	5497152
ChEMBL	N/A
IUPHAR	2906
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Kd	2511.89 nM	PMID9705355	IUPHAR

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