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Name | Sphingosine 1-phosphate receptor 2 |
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Species | Rattus norvegicus (Rat) |
Gene | S1pr2 |
Synonym | S1P2 receptor S1P2 S1P receptor Edg-5 S1P receptor 2 GPCR18 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 352 |
Amino acid sequence | MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV |
UniProt | P47752 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3616360 |
IUPHAR | 276 |
DrugBank | N/A |
Name | Jte 013 |
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Molecular formula | C17H19Cl2N7O |
IUPAC name | 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea |
Molecular weight | 408.287 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 4.4 |
Synonyms | HMS3650O12 pyrazolopyridine analog ZINC13813291 AKOS024457073 D03MTM [ Show all ] |
Inchi Key | RNSLRQNDXRSASX-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27) |
PubChem CID | 10223146 |
ChEMBL | CHEMBL1368758 |
IUPHAR | 2917 |
BindingDB | 50065628 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 17.0 - 22.0 nM | PMID12557151, PMID12445827 | IUPHAR |
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