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GPCR

NameSphingosine 1-phosphate receptor 2
SpeciesRattus norvegicus (Rat)
GeneS1pr2
SynonymS1P2 receptor
S1P2
S1P receptor Edg-5
S1P receptor 2
GPCR18
[ Show all ]
DiseaseN/A for non-human GPCRs
Length352
Amino acid sequenceMGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
UniProtP47752
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3616360
IUPHAR276
DrugBankN/A

Ligand

NameJte 013
Molecular formulaC17H19Cl2N7O
IUPAC name1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea
Molecular weight408.287
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP4.4
SynonymsHMS3650O12
pyrazolopyridine analog
ZINC13813291
AKOS024457073
D03MTM
[ Show all ]
Inchi KeyRNSLRQNDXRSASX-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H19Cl2N7O/c1-8(2)11-7-14(22-16-15(11)9(3)25-26(16)4)23-24-17(27)20-10-5-12(18)21-13(19)6-10/h5-8H,1-4H3,(H,22,23)(H2,20,21,24,27)
PubChem CID10223146
ChEMBLCHEMBL1368758
IUPHAR2917
BindingDB50065628
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5017.0 - 22.0 nMPMID12557151, PMID12445827IUPHAR

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