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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Succinate receptor 1
Species	Homo sapiens (Human)
Gene	SUCNR1
Synonym	succinate receptor 1 succinate receptor P2Y purinoceptor 1-like P2Y purinoceptor 1 GPR91 G-protein coupled receptor 91 G protein-coupled receptor 91 SUCNR1 [ Show all ]
Disease	N/A
Length	334
Amino acid sequence	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProt	Q9BXA5
Protein Data Bank	N/A
GPCR-HGmod model	Q9BXA5
3D structure model	This predicted structure model is from GPCR-EXP Q9BXA5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2150838
IUPHAR	166
DrugBank	BE0002258

Ligand

Name	696-74-2
Molecular formula	C5H6O4
IUPAC name	(1S,2R)-cyclopropane-1,2-dicarboxylic acid
Molecular weight	130.099
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	-0.6
Synonyms	AJ-63355 CS-0053628 SCHEMBL373882 (1s,2r)-cyclopropane-1,2-dicarboxylic acid 1,2-Cyclopropanedicarboxylic acid, cis- AX8222188 GTPL9632 AC1LDWJ0 cis-1,2-cyclopropanedicarboxylic acid MolPort-000-655-402 (1R,2S)-rel-Cyclopropane-1,2-dicarboxylic acid AKOS002347419 CTK8E0120 ZINC134528 (Z)-1,2-Cyclopropanedicarboxylic acid BBV-38272798 KS-000005FJ (1R,2S)-1,2-Cyclopropanedicarboxylic acid AC1Q5R3T cis-cyclopropane-1,2-dicarboxylic acid RLWFMZKPPHHHCB-WSOKHJQSSA-N (1R,2S)?rel-cyclopropane?1,2?dicarboxylic acid AS-52835 FCH2689383 0769AC cis 1,2-cyclopropane dicarboxylic acid MCULE-4280807741 (1r,2s)-cyclopropane-1,2-dicarboxylic acid [ Show all ]
Inchi Key	RLWFMZKPPHHHCB-WSOKHJQSSA-N
Inchi ID	InChI=1S/C5H6O4/c6-4(7)2-1-3(2)5(8)9/h2-3H,1H2,(H,6,7)(H,8,9)/t2-,3+
PubChem CID	726455
ChEMBL	N/A
IUPHAR	9632
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	49000.0 nM	PMID28160606	IUPHAR

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